Topical Medicine Potency of Musa paradisiaca var. sapientum (L.) kuntze as Oral Gel for Wound Healing: An In Vitro, In Vivo Study

Abstract

Objective Topical application of ambonese banana (Musa paradisiaca var. sapientum (L.) kuntze) stem sap gel (GEGPA) on the socket wound area showed an increase in the expression of platelet-derived growth factor-BB, while decrease in the expression of matrix metalloproteinase-2 and 9. The aim of this study is to achieve standard formulation of GEGPA through stability, viscosity, distribution area, and drugs release for oral gel wound healing. Materials and Methods This is an in vitro and in vivo study with the randomized posttest only control group design. The gel was formulated according to the composition of each group by adding hydroxypropyl methylcellulose (HPMC), Lexgard, propylene glycol, and cold water to obtain 100 g of gel. Observations were made through the following tests: stability, viscosity, distribution area, drug release, and histopathological analysis of tooth extraction wound healing. Statistical analysis Data were analyzed using a one-way analysis of variance (α = 0.05) with GraphPad Prism-8 statistical software. Results The study showed that the GEGPA formulation was stable against changes in consistency, color, smell, homogeneity, and pH value. There is a significant difference between groups with respect to viscosity (p = 0.0001), adhesion (p = 0.004), dispersion (p = 0.000), and fibroblast cell numbers on days 3 and 5 (p = 0.007 and p = 0.001). There is no interaction between the active ingredients and the gel base of all formulations. Formulation 3 had better properties in terms of viscosity, broad distribution, and drug release compared with other groups. Application of GEGPA to tooth extraction wounds showed a significant proliferation of fibroblast cells on days 3 and 5. Conclusions The formulation of M. paradisiaca var. sapientum (L.) kuntze extract with HPMC and propylene glycol obtained a gel preparation, GEGPA, that was organoleptically stable and met the topical gel standard for wounds in the oral cavity.

Novel Application of 3D Scaffolds of Poly(E-Caprolactone)/Graphene as Osteoinductive Properties in Bone Defect

“…Cell migration and proliferation are required for a range of physiological and pathological processes, including wound healing, 20 revascularization, cartilage regeneration, and bone regeneration. 21 22 Cell migration can be induced by biochemical and biophysical cues such as the mechanical properties of matrix, peptides, and growth factors in an immobilized and free form, respectively, which are referred to as mechanotaxis, haptotaxis, and chemotaxis.…”

Exploring the Efficacy of Musa Cavendish Stem Extract (Mucase) as a Novel Wound Dressing: A Comparative Study With Sofratulle®

“…Two processing methods were employed: oven-drying for six hours at 60 °C for the initial trial and indirect sun-drying for two to three days, which proved to be the best method after evaluation of the initial trial (Figure 1 for the extraction process). The processed stems were ground and sifted to produce a powder with a mesh size of 40 [ 16 ].…”

Active Ingredients and Natural Raw Materials Used in Foot Care in Diabetic Patients—A Literature Review

“…In folk medicine, plantain is used for the treatment of conditions such as diabetes, ulcers, and slow-healing wounds due to its hypoglycemic, anti-ulcer, and analgesic properties. Phytochemical studies of plantain stem juice have shown the presence of tannins and alkaloids, which are pharmacologically active compounds that have been experimentally confirmed [38][39][40]. There is a significant correlation between the phenolic content of the plant and its anti-diabetic effects.…”