Topical Minocycline Foam 4%: A Review in Acne Vulgaris

Paik, Julia

doi:10.1007/s40257-020-00523-1

Cited by 15 publications

(18 citation statements)

References 16 publications

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“…In addition, minocycline lacks immunogenicity and has fluidity and formability, with simple tube sealing operation and easy injection and drug replacement. [ 17 – 19 ]. Moreover, the combined therapy of minocycline plus zinc oxide eugenol cement resulted in a higher treatment efficacy versus minocycline alone, for which several possible explanations are available.…”

Section: Discussionmentioning

confidence: 99%

Minocycline plus Zinc Oxide Eugenol Cement Might Be A Promising Alternative for Acute Pulpitis

Song

Lei

Liu

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the clinical effect of minocycline plus zinc oxide eugenol cement in the treatment of acute pulpitis and its effect on the levels of HIF-1α, Bcl-2, and tumor necrosis factor α. Methods. A total of 286 patients with acute pulpitis who were treated in our hospital from January 2019 to October 2020 were recruited and assigned (1 : 1) via random number table method to receive either minocycline (control group) or minocycline plus zinc oxide eugenol cement (study group). Outcome measures included treatment effect, tooth mobility, tooth percussion pain score, hypoxia-inducible factor (HIF)-1α and B-lymphocyte tumor (Bcl)-2 positive rate, and tumor necrosis factor (TNF-α). Results. Minocycline plus zinc oxide eugenol cement was associated with significantly lower scores of teeth mobility and percussion pain versus minocycline alone ( p < 0.05 ). Minocycline plus zinc oxide eugenol cement resulted in a significantly higher treatment efficacy (97.20%) versus minocycline alone (72.73%) ( p < 0.05 ). Minocycline plus zinc oxide eugenol cement was associated with significantly lower positive rates of HIF-1α and Bcl-2 and lower levels of TNF-α versus minocycline alone ( p < 0.05 ). The patients receiving minocycline plus zinc oxide eugenol cement showed significantly lower visual analogue scale (VAS) scores and faster pain relief versus those given minocycline alone ( p < 0.05 ). Conclusion. Minocycline plus zinc oxide eugenol cement offers a viable alternative for acute pulpitis as it mitigates the pain of patients, alleviates inflammatory responses, and lowers the positive rate of HIF-1α and Bcl-2, so it is worthy of clinical promotion.

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Section: Discussionmentioning

confidence: 99%

Minocycline plus Zinc Oxide Eugenol Cement Might Be A Promising Alternative for Acute Pulpitis

Song

Lei

Liu

2022

Evidence-Based Complementary and Alternative Medicine

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“…19 Many studies showed that topical minocycline 4% foam was effective at improving acne within 12 weeks; however, a 40 week extension study showed that patients taking this drug continued to show improvement at 52 weeks after treatment. 19,20 Most patients enrolled in clinical trials studying topical minocycline 4% foam tolerated this drug well, with increased creatinine phosphokinase levels and headaches reported as the most common adverse events. 17,18 Topical sodium sulfacetamide is a bacteriostatic antibacterial that functions by halting bacterial DNA synthesis through inhibiting paraaminobenzoic acid.…”

Section: Antibacterial Agentsmentioning

confidence: 99%

“…Amzeeq™, 4% minocycline topical foam, was approved in 2019 by the FDA to treat moderate‐to‐severe, non‐nodular acne in patients older than age 9. This drug is lipophilic and moves through sebum to the pilosebaceous unit 19 . Although the exact mechanism of this drug is not well understood, studies have shown that this agent possesses potent antibacterial effects 19 .…”

Section: Acne Treatmentsmentioning

confidence: 99%

“…This drug is lipophilic and moves through sebum to the pilosebaceous unit 19 . Although the exact mechanism of this drug is not well understood, studies have shown that this agent possesses potent antibacterial effects 19 . Many studies showed that topical minocycline 4% foam was effective at improving acne within 12 weeks; however, a 40 week extension study showed that patients taking this drug continued to show improvement at 52 weeks after treatment 19,20 .…”

Section: Acne Treatmentsmentioning

confidence: 99%

“…Although the exact mechanism of this drug is not well understood, studies have shown that this agent possesses potent antibacterial effects 19 . Many studies showed that topical minocycline 4% foam was effective at improving acne within 12 weeks; however, a 40 week extension study showed that patients taking this drug continued to show improvement at 52 weeks after treatment 19,20 . Most patients enrolled in clinical trials studying topical minocycline 4% foam tolerated this drug well, with increased creatinine phosphokinase levels and headaches reported as the most common adverse events 17,18 …”

Section: Acne Treatmentsmentioning

confidence: 99%

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Acne affects approximately 9% of people worldwide and is the most common skin condition in the USA. There are abundant topical and oral treatment options available for patients with acne. First-line agents include topical retinoids, azelaic acid, benzoyl peroxide, and combinations of these agents. For recalcitrant or more severe acne, oral medications, including oral antibiotics, isotretinoin, or hormonal therapy, may be considered. This review will also discuss the many advances being made in the treatment of acne vulgaris, from the development of microencapsulated medications to targeted treatments.

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Rook's Textbook of Dermatology

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Acne (also known as acne vulgaris) is one of the most common inflammatory dermatoses seen globally. It can result in significant and indelible scarring and pigment change as well as profound psychosocial issues as a result of clinically active acne and resulting sequelae. This chapter covers the numerous clinical presentations and associations of acne and considers optimum management regimes for all.

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Topical Minocycline Foam 4%: A Review in Acne Vulgaris

Cited by 15 publications

References 16 publications

Minocycline plus Zinc Oxide Eugenol Cement Might Be A Promising Alternative for Acute Pulpitis

Minocycline plus Zinc Oxide Eugenol Cement Might Be A Promising Alternative for Acute Pulpitis

Acne treatment review and future perspectives

Acne

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