Topical mitomycin C—induced inhibition of postlaminectomy peridural fibrosis in rabbits

Doğulu, Fikret; Kurt, Gökhan; Emmez, Hakan; Erdem, Özlem; Memış, Leyla; Baykaner, Kemali; Çeviker, Necdet

doi:10.3171/spi.2003.99.1.0076

Cited by 28 publications

(47 citation statements)

References 26 publications

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“…Due to the controversial results of physical and mechanical barriers, attempts have been made to apply chemical barriers such as corticoids, activators of tissue plasminogen [2], mitomycin C, urokinase [9] and elastase. However, these are no longer used [2,4,5,14].…”

Section: Discussionmentioning

confidence: 99%

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Preventing peridural fibrosis with nonsteroidal anti-inflammatory drugs

Sandoval

Hernández-Vaquero

2008

Eur Spine J

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Peridural fibrosis is one of the more frequent complications of lumbar surgery. Nonsteroidal antiinflammatory drugs inhibit the inflammatory and fibroblastic response. We performed lumbar laminectomies in 24 rabbits, divided into two groups. The experimental group received 5 mg/kg/day of aceclofenac for 7 days and the control group received 1 cm 3 of physiological saline. The samples were stained using immunohistochemical methods. The cellular populations in the inflammatory reaction and the thickness of the fibrous membrane were quantified. The mean of the fibrous area was always less in the rabbits of the experimental group compared to controls (47% less at 2 weeks and 41% less at 4 weeks). We observed an 8% decrease in the number of fibroblasts with antivimentin monoclonal antibodies in the experimental group. In this model, aceclofenac inhibits the presence of inflammatory cells in the fibrous scar in the early stages and reduces the extension of adhesions without adverse reactions.

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Section: Discussionmentioning

confidence: 99%

“…Meticulous surgery, as a preventive intraoperative measure, has been suggested [6,25] with careful hemostasis and the placement of physical [11,21] and chemical [4,9,13] barriers between the paravertebral musculature and the dura. The nonsteroidal anti-inflammatory drugs (NSAIDs) are the examples of systemic chemical barrier.…”

Section: Introductionmentioning

confidence: 99%

Preventing peridural fibrosis with nonsteroidal anti-inflammatory drugs

Sandoval

Hernández-Vaquero

2008

Eur Spine J

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“…A multitude of studies have been performed to evaluate the use of various products as antiadhesion barriers [2], [6], [9], [10], [13], [20], [22], [24], [25], [27], [28], [30], [31], [32], [33], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [52], [53], [54], [55], [56], [57], [59], [60], [61], [62], [64], [65], [67], [68], [69], [70] . Although scar formation is a normal part of the healing process, excessive scarring or scarring in regions where adhesions cause anatomical dysfunction (eg, intestinal adhesions) is detrimental.…”

Section: Discussionmentioning

confidence: 99%

Bioresorbable film for the prevention of adhesion to the anterior spine after anterolateral discectomy

Klopp¹,

Toth²,

Welch³

et al. 2009

The Spine Journal

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“…Reoperation for failed back syndrome is usually unsuccessful and might cause surgical complications 8 . Non steroidal anti-inflammatory drugs (NSAIDs) 15 , Gelfoam 27 , Goretex 22,25 , carboxymethil cellulose 33 , Adcon-L 11,21 , autogenous adipose grefting 13 , mitomisin 10 , and radiotherapy 12 have been investigated as potential treatments for the prevention of scar formation after spine surgery in the last decades. Most studies provide only a qualitative evaluation of the scar formation after laminectomy therefore it is difficult to make comparisons among the different agents.…”

Section: Introductionmentioning

confidence: 99%

“…Several materials have been tested as barriers to reduce the extent of peridural fibrosis [10][11][12][13]15,25,27,32,33 . None of the barrier materials have been universally accepted for this use 1 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of Oxiplex and Gore-Tex effectivity in an experimental peridural fibrosis model

et al. 2009

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SummaryObjective. The authors conducted a study to compare the effectiveness of Oxiplex and Gore-tex in preventing postlaminectomy peridural fibrosis in rats. Peridural fibrosis is a common cause of pain in patients undergoing spinal surgery. To prevent scar formation numerous materials and methods have been employed such as non steroidal anti-inflammatory drugs (NSAIDs), Gelfoam, Oxiplex, Gore-tex, carboxymethil cellulose, Adcon-L, autogenous adipose grefting, mitomisin, and radiotherapy have been investigating for a long time, but only moderate success has been obtained.Methods. Laminectomies were performed at the fourth lumbar vertebra (L-4) in 30 rats. Oxiplex or Gore-Tex was applied over the dura mater with the aim to perform a blinded evaluation of their effects. In the control group, only a L-4 laminectomy was performed. Animals were sacrificed 28 days after the surgical procedure. The extent of peridural fibrosis was evaluated on spine specimens by histological analysis.Results. Both groups of animals treated with either Oxiplex or Gore-Tex showed a significant reduction in the degree of peridural fibrosis as compared to the control group. However no significant difference in the prevention of peridural fibrosis was observed between the Oxiplex and Gore-Tex groups.Conclusions. This experimental model has shown that Oxiplex and Gore-Tex are effective methods to prevent peridural fibrosis and dural adhesions at the postlaminectomy areas.KEY WORDS: Peridural fibrosis. Oxiplex. Gore-Tex. Failed back syndrome.Comparación entre la eficacia del Oxiplex y del GoreTex en un modelo experimental de fibrosis peridural ResumenObjetivo. Los autores realizaron un estudio para comparar la eficacia de Oxiplex y Gore-tex en la prevención de fibrosis peridural tras laminectomías en ratas. La fibrosis peridural es una causa común de dolor en pacientes sometidos a cirugía de la columna vertebral. Para evitar la formación de cicatriz, se han empleado numerosos materiales y métodos como los antiinflamatorios no esteroideos (AINE), Gelfoam, Oxiplex, Gore-tex, carboxymethil celulosa, Adcon-L, injertos de grasa antóloga, mitomicina o la radioterapia, pero sólo se ha obtenido resultados exitosos en pocas ocasiones.Métodos. Se realizaron laminectomías en la cuarta vértebra lumbar (L-4) en 30 ratas. Se aplicaron Oxiplex o Gore-Tex sobre la duramadre con el objetivo de realizar una evaluación ciega de sus efectos. En el grupo control, sólo se realizó la laminectomía L4. Los animales fueron sacrificados 28 días después de la intervención quirúrgica. El grado de fibrosis peridural se evaluó sobre la columna vertebral de especímenes por análisis histológico.Resultados. Ambos grupos de animales tratados con Oxiplex o Gore-Tex mostraron una reducción significativa en el grado de fibrosis peridural en comparación con el grupo control. Sin embargo, ninguna diferencia significativa en la prevención de la fibrosis peridural se observó entre los grupos de Oxiplex y Gore-Tex.Conclusiones. Este modelo experimental ha demostrado que Oxiplex y Gor...

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Topical mitomycin C—induced inhibition of postlaminectomy peridural fibrosis in rabbits

Cited by 28 publications

References 26 publications

Preventing peridural fibrosis with nonsteroidal anti-inflammatory drugs

Preventing peridural fibrosis with nonsteroidal anti-inflammatory drugs

Bioresorbable film for the prevention of adhesion to the anterior spine after anterolateral discectomy

Comparison of Oxiplex and Gore-Tex effectivity in an experimental peridural fibrosis model

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