Topical Modalities for Treatment and Prevention of Postsurgical Hypertrophic Scars

Foo, Chong Wee; Tristani‐Firouzi, Payam

doi:10.1016/j.fsc.2011.06.008

Cited by 29 publications

(17 citation statements)

References 40 publications

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“…As SGS is safe and non-invasive, it can be used for both prevention and treatment [13]. Foo et al [29] reported that there was no single universally accepted treatment that can eliminate hypertrophic scars; however, SGS remains the most accepted modality for treatment and prevention of scars.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of an Advanced Formula Silicone Gel for Prevention of Post-Operative Scars

Medhi

Sewal

Kaman

et al. 2013

Dermatol Ther (Heidelb)

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IntroductionScar formation is a natural part of the healing process that occurs when the skin repairs wounds caused by burns, trauma, surgery or disease. The appearance of scars often leads to adverse psychological effects, loss of self-esteem and the associated stigmatism and diminished quality of life. Silicones are emerging as the standard treatment for prevention of a wide range of scars. The present study evaluated the safety and efficacy of an advanced formula topical silicone gel for prevention of post-operative hypertrophic and keloid scars.MethodsAn open-label prospective trial was conducted. Patients who had undergone prior surgery (10 days–3 weeks) and having recent post-surgical scars were enrolled. Patients were asked to apply the gel twice daily to the affected areas for 3 months. Pigmentation, vascularity, pliability, height of scar and pain and pruritus in the scar were assessed. Photographs of scars were taken before commencement of treatment and at follow-up visits.ResultsA total of 36 patients were enrolled. At baseline, height of the scar was 2–5 mm in 57.6 % (19/33) of the subjects which was reduced in subsequent visits (P < 0.05). Hyperpigmentation (score 3) was present in 91% (30/33) of patients at baseline and was reduced to normal (score 0) after 2 months of treatment in 40% (6/14) of patients (P = 0.0313). Vascularity (54.6%, 18/33) at baseline was also reduced over the 3 months period (P = 0.0313) A significant decrease (30%, 3/10) (P = 0.0313) in pliability was seen after 3 months of treatment from the baseline (57.6%, 19/33). Only two patients reported pruritus and pain at the baseline visit; one patient reported improvement after treatment. Itching was reported as an adverse drug reaction in two patients.ConclusionThese preliminary findings suggest that advanced formula silicone gel is safe and effective in the prevention of hypertrophic and keloid scars; however, larger, controlled studies are warranted.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-013-0036-8) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of an Advanced Formula Silicone Gel for Prevention of Post-Operative Scars

Medhi

Sewal

Kaman

et al. 2013

Dermatol Ther (Heidelb)

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“…Another treatment method is the application of mechanical pressure to the scar surface via pressure garments to decrease blood and oxygen flow into the scar tissue, which may reduce cellular proliferation and prevent excessive scarring . Other studies recommend the use of more invasive methods such as intralesional injections of corticosteroids, chemotherapeutics, bleomycin, Botox, and other substances to interfere in the process of pathological scarring . Additionally, there exist many physical therapy options with the intent to break down and/or remodel excessive scar tissue.…”

Section: Introductionmentioning

confidence: 99%

Evidence of invasive and noninvasive treatment modalities for hypertrophic scars: A systematic review

Kafka

Collins

Kamolz

et al. 2017

Wound Repair Regeneration

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Currently, there are various therapeutic approaches to reduce hypertrophic scarring; however, there is no standard evidence-based treatment protocol. Hence, a systematic review was performed to obtain a summary of the latest clinical trials to evaluate evidence for the treatment of hypertrophic scars. The review protocol was registered and approved by PROSPERO (CRD42015027040). PubMed and Web of Science were searched using predefined MeSH-Terms to identify studies published within the last 10 years regarding treatment for hypertrophic scars. Exclusion criteria included a level of evidence (LoE) lower than I, nonhuman in vivo studies, in vitro studies, studies on keloids, literature reviews, and non-English articles. The literature search identified 1,029 unique articles, whereas 6 articles were prospective, randomized, blinded, controlled clinical trials with a LoE I, and were thus included in the systematic analysis. Three clinical trials evaluated silicone products and pressure garments, and the other three studies investigated the efficacy of intralesional injections of triamcinolone (TAC), 5-Fluorouracil (5-FU) combined with TAC as well as the additional irradiation with a 585 nm pulsed-dye laser (PDL). Intralesional injections revealed significant improvements of the scar quality in terms of height, thickness, erythema, and pigmentation. Pressure garments showed favorable results but there was no evidence that silicone products were able to improve the scar quality. The systematic review demonstrated that there are just a few clinical trials with a LoE of I. Consequently, evidence is still lacking especially for noninvasive treatment regimens for hypertrophic scars. Intralesional injections of 5-FU mixed with a low dose of TAC can be seen as most appropriate treatment modality. Prospective clinical trials to determine the efficiency of silicone products are warranted.

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“…Pressure treatment is widely used in the plastic surgery and burn scar prevention it prevents and restricts scar formation by imposing appropriate pressure on the body surface [26]. We have found it useful for enhancing wound remodeling in cases of free-flap transfer.…”

Section: Discussionmentioning

confidence: 99%

One-stage cosmetic finger reconstruction using a second toe island flap containing terminal branches of the toe artery

Hou

2015

Orthopaedics & Traumatology: Surgery & Research

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Topical Modalities for Treatment and Prevention of Postsurgical Hypertrophic Scars

Cited by 29 publications

References 40 publications

Efficacy and Safety of an Advanced Formula Silicone Gel for Prevention of Post-Operative Scars

Efficacy and Safety of an Advanced Formula Silicone Gel for Prevention of Post-Operative Scars

Evidence of invasive and noninvasive treatment modalities for hypertrophic scars: A systematic review

One-stage cosmetic finger reconstruction using a second toe island flap containing terminal branches of the toe artery

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