Topical nitroglycerin: A promising treatment option for chondrodermatitis nodularis helicis

Flynn, Valerie; Chisholm, Cary; Grimwood, Ronald E.

doi:10.1016/j.jaad.2010.06.012

Cited by 27 publications

(10 citation statements)

References 20 publications

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“…described a series of 12 patients treated with nitroglycerin CNH 2% gel once every 12 hours for 3 months with improvement rates up to 92%. Of these, 61.5% had complete disappearance of visible injury and pain, 30.8% achieved disappearance of pain but with persistence of some degree of visible lesion . A small study with a cohort of five patients who received topical steroids reported a 100% success rate .…”

Section: Discussionmentioning

confidence: 98%

Nitroglycerin patch for the treatment of chondrodermatitis nodularis helicis: a new therapeutic option

et al. 2014

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Chondrodermatitis nodularis helicis (CNH) is an inflammatory process that affects the skin and cartilage of the ear. At present, there are many treatment options, although they are not always effective. Based on previous studies where nitroglycerin 2% gel was used, we propose the use of nitroglycerin patches. The purpose of this study was to evaluate the effectiveness of nitroglycerin patches in treating CNH. We performed a prospective study in 11 patients diagnosed with CNH treated with nitroglycerin patches 5 mg, 12 hours a day for 2 months. The therapeutic effectivity was determined by the improvement in the appearance and symptoms of the lesion. Seven of 11 patients (63.6%) had a complete response. One of 11 patients (9%) did not respond completely and surgical treatment was performed. Two of 11 patients (18.1%) stopped the treatment because of headache. One of 11 patients (9%) did not complete the treatment because the said patient forgot to apply the patch every night. Transdermal nitroglycerin has demonstrated efficacy in the treatment of the symptoms and lesional appearance of CNH noninvasive manner. The success rate is comparable with other published methods and the rate of adverse effects is acceptable.

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Section: Discussionmentioning

confidence: 98%

Nitroglycerin patch for the treatment of chondrodermatitis nodularis helicis: a new therapeutic option

et al. 2014

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“…Recurrence is often high, and many treatment options have been introduced, including surgical excision, electrodesiccation, pressure-relieving prosthesis, photodynamic therapy, injectable collagen, and topical nitroglycerine. [1][2][3][4][5] The most widely referenced surgical approach is cartilage-only excision, described initially by Lawrence in 1991, 1 with modifications of his method being reported in the literature with equally acceptable results. 6 The fundamentals of this method include removal of diseased cartilage with preservation of skin.…”

Section: Discussionmentioning

confidence: 99%

Triangular Window Technique: A Novel Approach for the Surgical Treatment of Chondrodermatitis Nodularis Helicis

Cognetta

Wolfe

Green

et al. 2012

Dermatologic Surgery

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“…Topical nitroglycerin is indicated in several dermatologic disorders with vasoconstriction as a common pathogenic mechanism, but with variable clinical manifestations, such as Raynaud syndrome, chondrodermatitis nodularis helicis, cutaneous ulcers, pernio erythema, alopecia areata, tissular necrosis after dermal filler injections [11,12].…”

Section: Experimental Partmentioning

confidence: 99%

Nitroglycerin in Dermatology

Toader¹,

Mocanu²,

Iancu³

et al. 2020

Rev. Chim.

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Nitroglycerin has traditionally been used in medicine for over 130 years for its potent dilator effect on both venous and arterial blood vessels. Cardiovascular ischemic diseases are among the classic indications. However, the possibility to incorporate nitroglycerin in different galenic forms renders it new therapeutic potential through topical application, both in surgery and in dermatology (Raynaud syndrome, chondrodermatitis, pernio erythema, alopecia areata, ulcers of different etiologies). Nitroglycerin is used for topical treatment as 0.5%, 1% or 2% ointment, lower concentrations limiting the probability of systemic adverse effects occurence.

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Topical nitroglycerin: A promising treatment option for chondrodermatitis nodularis helicis

Cited by 27 publications

References 20 publications

Nitroglycerin patch for the treatment of chondrodermatitis nodularis helicis: a new therapeutic option

Nitroglycerin patch for the treatment of chondrodermatitis nodularis helicis: a new therapeutic option

Triangular Window Technique: A Novel Approach for the Surgical Treatment of Chondrodermatitis Nodularis Helicis

Nitroglycerin in Dermatology

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