Topical Oral Wound Healing Potential of Anthocyanin complex: Animal and Clinical Studies

Limsitthichaikoon, Sucharat; Khampaenjiraroch, Bhattaranitch; Damrongrungruang, Teerasak; Limphirat, Wanwisa; Thapphasaraphong, Suthasinee; Priprem, Aroonsri

doi:10.4155/tde-2017-0123

Cited by 21 publications

(13 citation statements)

References 45 publications

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“…ANT-demonstrated benefits include protection against diabetes [6, 7], impressive reduction of blood pressure, enhancement of vision [8, 9], and strong anti-inflammatory effects [10, 11]. These phenolic compounds also facilitate dermal and oral wound healing [11, 12]. Fibroblast proliferation influences the formation of granulation tissue, collagen synthesis, and wound contraction.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Properties of Anthocyanins Extracted from Oryza sativa L. in Primary Dermal Fibroblasts

Palungwachira

Tancharoen

Phruksaniyom

et al. 2019

Oxidative Medicine and Cellular Longevity

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Flavonoids are naturally active substances that form a large class of phenolic compounds abundant in certain foods. Black rice (Oryza sativa L.) contains high levels of anthocyanin polyphenols, which have beneficial effects on health owing to their antioxidant properties. The breakdown of collagenous networks with aging or skin deterioration results in the impairment of wound healing in the skin. Accordingly, reviving stagnant collagen synthesis can help maintain dermal homeostasis during wound healing. This study presents an assessment of the cellular activity of anthocyanins (ANT) extracted from Oryza sativa L., providing information necessary for the development of new products that support natural healing processes. The relative composition of ANT from Oryza sativa L. was determined by high-performance liquid chromatography/diode array detection. ANT promoted the migration of rat dermal fibroblasts (RDFs) and demonstrated antioxidant properties. ANT increased the mRNA expression of collagen type I alpha 2 (COL1A2) and upregulated type I collagen protein levels in H2O2-stimulated RDFs without cytotoxicity. Compared with the untreated group, treatment of RDFs with ANT in the presence of H2O2 led to the activation of signaling pathways, including the extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) and Akt, whereas it significantly (p<0.001) inhibited the phosphorylation of IκBα and suppressed the activation of the nuclear factor-kappa B (NF-κB) subunits, p50 and p65, which are transcription factors responsible for inflammation. Taken together, our findings suggest that ANT from Oryza sativa L. have anti-inflammatory properties and antiaging potential by modulating type I collagen gene expression and suppressing H2O2-induced NF-κB activation in skin fibroblasts.

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Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Properties of Anthocyanins Extracted from Oryza sativa L. in Primary Dermal Fibroblasts

Palungwachira

Tancharoen

Phruksaniyom

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…Each FPM solution contained in a 5 mL syringe and weighing approximately 5 g and was loaded into the donor chamber, and the receptor chamber was filled with 1% bovine serum albumin solution (Sigma-Aldrich, USA) in phosphate buffer at pH 7.4 to maintain a sink condition [ 16 ]. This was stirred at 600 rpm at 37 ± 2 °C.…”

Section: Methodsmentioning

confidence: 99%

Polymeric Micelles Enhance Mucosal Contact Time and Deposition of Fluocinolone Acetonide

et al. 2022

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This study used polymeric micelles to improve quality by increasing drug solubility, extending mucosal drug retention time, enhancing mucoadhesiveness, and promoting drug permeation and deposition. Fluocinolone acetonide (FA) was loaded into polymeric micelles (FPM), which were composed of poloxamer 407 (P407), sodium polyacrylate (SPA), and polyethylene glycol 400, and their physicochemical properties were examined. Small-angle X-ray scattering (SAXS) revealed a hexagonal micellar structure at all temperatures, and the concentrations of P407 and SPA were shown to significantly affect the solubility, mucoadhesion, release, and permeation of FPMs. The characteristics of FPM7 and FPM8 revealed crystalline states inside the micelles, which was consistent with the morphology and nano-hexagonal structure. The results of ex vivo experiments using focal plane array (FPA)-based Fourier transform infrared (FTIR) imaging showed that FPM7 penetrated quickly through the epithelium, lamina propria, and submucosa, and remained in all layers from 5–30 min following administration. In contrast, FPM8 penetrated and passed through all layers. FPMs with extended mucoadhesion, improved drug–mucosal retention time, and increased FA permeation and deposition were successfully developed, and could be a promising innovation for increasing the efficiency of mouth rinses, as well as other topical pharmaceutical and dental applications.

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“…In the animal model, a reduction in the erythema and the sizes of oral wounds was observed compared to placebo gel. In the clinical trial, wound closure enhancement was observed on day 3 of anthocyanin gel application [216].…”

Section: Medicinal Products Developed With Ansmentioning

confidence: 99%

Anthocyanins as Key Phytochemicals Acting for the Prevention of Metabolic Diseases: An Overview

et al. 2022

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Anthocyanins are water-soluble pigments present in fruits and vegetables, which render them an extensive range of colors. They have a wide distribution in the human diet, are innocuous, and, based on numerous studies, have supposed preventive and therapeutical benefits against chronic affections such as inflammatory, neurological, cardiovascular, digestive disorders, diabetes, and cancer, mostly due to their antioxidant action. Despite their great potential as pharmaceutical applications, they have a rather limited use because of their rather low stability to environmental variations. Their absorption was noticed to occur best in the stomach and small intestine, but the pH fluctuation of the digestive system impacts their rapid degradation. Urine excretion and tissue distribution also occur at low rates. The aim of this review is to highlight the chemical characteristics of anthocyanins and emphasize their weaknesses regarding bioavailability. It also targets to deliver an update on the recent advances in the involvement of anthocyanins in different pathologies with a focus on in vivo, in vitro, animal, and human clinical trials.

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Topical Oral Wound Healing Potential of Anthocyanin complex: Animal and Clinical Studies

Abstract: At 10% w/w, AC promoted wound closure and possessed a potential in healing stimulation of acute oral wounds.

Cited by 21 publications

References 45 publications

Antioxidant and Anti-Inflammatory Properties of Anthocyanins Extracted from Oryza sativa L. in Primary Dermal Fibroblasts

Antioxidant and Anti-Inflammatory Properties of Anthocyanins Extracted from Oryza sativa L. in Primary Dermal Fibroblasts

Polymeric Micelles Enhance Mucosal Contact Time and Deposition of Fluocinolone Acetonide

Anthocyanins as Key Phytochemicals Acting for the Prevention of Metabolic Diseases: An Overview

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