Topical Oxygen for Chronic Wounds: A PRO/CON Debate

Mutluoğlu, Mesut; Cakkalkurt, Aslican; Uzun, Günalp; Aktaş, Şamil

doi:10.1016/j.jccw.2014.12.003

Cited by 18 publications

(29 citation statements)

References 27 publications

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“…The wound tissue oxygen microenvironment has been previously studied by researchers, and non–healing chronic wounds can exhibit oxygen partial pressures (P o2 ) as low as 5 mmHg, as compared to healthy skin with a P o2 in the range of 10–40 mmHg [Mutluoglu et al, 2013]. Importantly, vital wound healing processes such as collagen synthesis, angiogenesis, and epithelialization require local oxygen bioavailability with a P o2 ranging from 25 mmHg to 100 mmHg [Tuderman et al, 1977; Edwards et al, 1984].…”

Section: Oxygen-delivery Approaches For Tissue Engineeringmentioning

confidence: 99%

Oxygen Regulation in Development: Lessons from Embryogenesis towards Tissue Engineering

Fathollahipour

Patil

Leipzig³

2018

Cells Tissues Organs

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Oxygen is a vital source of energy necessary to sustain and complete embryonic development. Not only is oxygen the driving force for many cellular functions and metabolism, but it is also involved in regulating stem cell fate, morphogenesis, and organogenesis. Low oxygen levels are the naturally preferred microenvironment for most processes during early development and mainly drive proliferation. Later on, more oxygen and also nutrients are needed for organogenesis and morphogenesis. Therefore, it is critical to maintain oxygen levels within a narrow range as required during development. Modulating oxygen tensions is performed via oxygen homeostasis mainly through the function of hypoxia-inducible factors. Through the function of these factors, oxygen levels are sensed and regulated in different tissues, starting from their embryonic state to adult development. To be able to mimic this process in a tissue engineering setting, it is important to understand the role and levels of oxygen in each developmental stage, from embryonic stem cell differentiation to organogenesis and morphogenesis. Taking lessons from native tissue microenvironments, researchers have explored approaches to control oxygen tensions such as hemoglobin-based, perfluorocarbon-based, and oxygen-generating biomaterials, within synthetic tissue engineering scaffolds and organoids, with the aim of overcoming insufficient or nonuniform oxygen levels and nutrient supply.

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Section: Oxygen-delivery Approaches For Tissue Engineeringmentioning

confidence: 99%

Oxygen Regulation in Development: Lessons from Embryogenesis towards Tissue Engineering

Fathollahipour

Patil

Leipzig³

2018

Cells Tissues Organs

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“…The penetration of oxygen across the surface of the skin occurs to a depth of up to 700 µm, validating the physiological basis of topical oxygen delivery [26]. The advantages of topical oxygen therapy as an intervention method are predominantly due to its costeffectiveness, the availability of a home treatment option, and the minimal risk of developing complications [27] as compared to hyperbaric oxygen therapy or topical hyperbaric oxygen therapy. There is only minimal damage to the vasculature due to oxygen penetration directly from the outer surface of the skin bypassing the oxygen transport system of the body.…”

Section: Role Of Topical Oxygen Therapy In Wound Healingmentioning

confidence: 98%

“…A potential aid to making this decision may consist in measuring transcutaneous oxygen tension levels in the wound area, which was addressed by Sano et al [16]. Also, topical oxygen therapy and its different modes of administration would most likely benefit all low-grade ulcers that have failed to heal following standard wound care by multidisciplinary healthcare teams [27]. Therefore, it can be readily chosen for individuals with low-grade diabetic foot ulcers.…”

Section: Which Ulcer Grades Benefit Most From Topical Oxygen Therapy?mentioning

confidence: 99%

Application of Topical Oxygen Therapy in Healing Dynamics of Diabetic Foot Ulcers - A Systematic Review

Nataraj

Maiya

Karkada

et al. 2019

Review of Diabetic Studies

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BACKGROUND: Individuals with diabetes may develop diabetic foot ulcers due to diabetic peripheral neuropathy. Multiple factors influence the ulcer healing process; oxygen helps in facilitating the different stages of wound healing. OBJECTIVE: The objective of this systematic review was to analyze the different levels of evidence available in the application of topical oxygen therapy, warm oxygen therapy, or other modes of topical oxygen delivery in the healing dynamics of diabetic foot ulcers. METHODS: Databases searched included Pubmed/Medline, Science Direct, Web of Science, Scopus, Cochrane, and CINAHL. The eligibility criteria of studies included participants ≥18 years with chronic non-healing diabetic foot ulcer (duration ≥3 months) receiving warm oxygen or topical oxygen therapy (TOT), and other modes of topical oxygen administration, which were compared with standard care group. Randomized and non-randomized studies were included. The primary outcome measure assessed was the rate of wound healing or wound closure. RESULTS: The review included 5 studies which used different modes of topical oxygen administration. The healing trajectory of the wounds was completely achieved in low-grade ulcers (grade 1), whereas all highgrade ulcers (grades 2, 3, and above) showed either 100% or 50% healing with a reduction in ulcer size and ulcer tissue depth. CONCLUSION: Topical oxygen therapy facilitates wound healing dynamics among individuals with chronic diabetic foot ulcers.

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“…Topical Pressurised Oxygen Therapy (TPOT) involves the use of a chamber or bag, which encloses the affected areas while administering 100% oxygen at a pressure that is slightly above 1 atm . This reduces costs, allows for in‐home treatment, and minimising the potential side effects associated with HBOT . Additionally, TPOT, unlike HBOT, provides no risk of systemic oxygen toxicity and, thus, can be administered until the wound is healed …”

Section: B Topical Pressurised Oxygen Therapymentioning

confidence: 99%

“…This reduces costs, allows for in‐home treatment, and minimising the potential side effects associated with HBOT . Additionally, TPOT, unlike HBOT, provides no risk of systemic oxygen toxicity and, thus, can be administered until the wound is healed …”

Section: B Topical Pressurised Oxygen Therapymentioning

confidence: 99%

Topical oxygen therapy & micro/nanobubbles: a new modality for tissue oxygen delivery

Sayadi

Banyard

Ziegler

et al. 2018

International Wound Journal

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Up to 15 billion dollars of US health care expenditure each year is consumed by treatment of poorly healing wounds whose etiologies are often associated with aberrancies in tissue oxygenation. To address this issue, several modes of tissue oxygen delivery systems exist, including Hyperbaric Oxygen Therapy (HBOT) and Topical Oxygen Therapy (TOT), but their efficacies have yet to be fully substantiated. Micro/nanobubbles (MNBs), which range anywhere from 100 μm to <1 μm in diameter and are relatively stable for hours, offer a new mode of oxygen delivery to wounds. The aim of this article is to systematically review literature examining the use of TOT for wound healing and use of MNBs for tissue oxygenation using the MEDLINE database. The search yielded 87 articles (12 MNB articles and 75 TOT articles), of which 52 met the inclusion criteria for this literature review (12 MNB articles and 40 TOT articles). Additionally, we present an analysis on the efficacy of our MNB generating technology and propose its use as a wound healing agent.

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Topical Oxygen for Chronic Wounds: A PRO/CON Debate

Cited by 18 publications

References 27 publications

Oxygen Regulation in Development: Lessons from Embryogenesis towards Tissue Engineering

Oxygen Regulation in Development: Lessons from Embryogenesis towards Tissue Engineering

Application of Topical Oxygen Therapy in Healing Dynamics of Diabetic Foot Ulcers - A Systematic Review

Topical oxygen therapy & micro/nanobubbles: a new modality for tissue oxygen delivery

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