Topical Permeation Characteristics of Diclofenac Sodium from NaCMC Gels in Comparison with Conventional Gel Formulations

Mohammed, F. A.

doi:10.1081/ddc-100108371

Cited by 29 publications

(10 citation statements)

References 30 publications

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“…The selection and characterization of an appropriate adhesive polymer is the first step in the development of a coated membrane. CMC (carboxy methyl cellulose) was chosen for the production of the bilayered membranes because it is biocompatible and water‐soluble 41. Adhesion of cellulose derivatives in biological systems results mainly from the pressure developed by their swollen gels against the mucin layer 42…”

Section: Methodsmentioning

confidence: 99%

Poly(vinyl alcohol) membranes for adhesion prevention

Weis¹,

Odermatt²,

Kreßler

et al. 2004

J Biomed Mater Res

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The abnormal joining of anatomic structures after abdominal and pelvic surgery can lead to such major complications as bowel obstruction or infertility. Poly(vinyl alcohol) (PVA) membranes and hydrogels were placed over the injured tissue to act as a physical barrier and prevent such adhesions from occurring in a rabbit sidewall model. The membranes were sutured into place to prevent their slipping or curling on the moist tissue. Various in vitro experiments (including testing for swelling and mechanical strength) were conducted in order to better understand the behavior of these membranes in the wound. The results showed that both the PVA membranes and PVA hydrogels significantly reduced the number and severity of adhesions in the rabbit sidewall model, and even indicated a distinct improvement over SEPRAFILM as antiadhesion barriers. Contact-angle measurements were taken in order to evaluate the surface properties of the membranes and hydrogels. Three approaches were taken to render the membranes more bioadhesive, and forego the need for future additional suturing: imprinting a texture onto the membrane, coating the membrane with carboxy methyl cellulose (CMC), and producing bi-layered, porous PVA membranes through a process of lyophilization. Though the surface of the PVA hydrogels is more hydrophilic than the surface of the PVA membranes, neither would adhere untreated to moist tissue. However, all three approaches aimed at improving their bioadhesion yielded excellent results and demonstrated that PVA could indeed be considered a viable method of adhesion prevention.

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Section: Methodsmentioning

confidence: 99%

Poly(vinyl alcohol) membranes for adhesion prevention

Weis¹,

Odermatt²,

Kreßler

et al. 2004

J Biomed Mater Res

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“…Especially, due to its biodegradability and nontoxicity, CMC and its derivatives have been used for an increasing number of applications in the food and cosmetics industries, such as viscosifiers, emulsion stabilizers, and as a means to improve texture (Heinze and Koschella 2005). In the pharmaceutical field, CMC (Kast and Bernkop Schnurch 2002;Mohammed 2001;Rao et al 2001) like other cellulose derivatives (Edgar 2007;Shanbhag et al 2007), are useful ingredients for the preparation of pharmaceutical formulations. In addition, due to its safety, CMC is a component of Seprafilm (Genzyme, MA, USA), which is widely used for preventing postoperative abdominal adhesion in general surgery (Zeng et al 2007).…”

Section: Introductionmentioning

confidence: 98%

Feasibility of carboxymethylcellulose with phenol moieties as a material for mammalian cell-enclosing subsieve-size capsules

et al. 2008

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Mammalian cell-enclosing capsules have been investigated as devices for bioproduction, cell therapy and stem cell research. In this study, carboxymethylcellulose (CMC) with phenol moieties (CMC-Ph), synthesized through the conjugation reaction of CMC and tyramine, was investigated as a material for these types of devices. Subsieve-size capsules of less than 100 lm in diameter were prepared by extruding aqueous CMC-Ph solution into co-flowing liquid paraffin containing H 2 O 2 . The capsule diameter was controlled between 60-220 lm by changing the flow rate of liquid paraffin. There was no harmful effect specific for CMC-Ph on mammalian cells enclosed in capsules. Feline kidney cells enclosed in subsieve-size CMC-Ph capsules exhibited 87.0 ± 4.5% viability. In addition, the enclosed cells continued to grow over 13 days of study. These results demonstrated the feasibility of CMC-Ph as a material for subsieve-size cell-enclosing capsules prepared via the droplet breakup technique in a co-flowing water-immiscible fluid.

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“…Figure 2 compares the structure of some types of traditional DDS and the respective hybrid systems. Table 2 shows relevant information of main published works International Journal of Polymer Science 9 Emulgel-jojoba oil/HPMC Clotrimazole - [46] Emulgel-xanthan gum Acyclovir and ketoconazole - [47] Emulgel-lecithin soy Ketoprofen - [113] Nanogel-agar Sodium diclofenac - [48] Emulgel-CMC Sodium diclofenac - [114] Emulgel-gelatin Metronidazole - [45] Poly(SMA)-neocarzinostatin Neocarzinostatin - [115] PEG-DNA DNA - [52] PEG-streptavidin Streptavidin - [116] PEG-L-asparaginase L-Asparaginase - [53] PEG-streptavidin Streptavidin - [117] PDMA-BSA DNA - [57] PMMA-BSA Camptothecin 11.0% [56] ELP-FKBP Rapamycin - [58] Liposome-chitosan Doxorubicin 98.0 % [78] Liposome-cellulose Quercetin 40.0% [77] Liposome-cellulose Rutin 58.0% [77] Liposome-gel Lidocaine 21.6% [118] Liposome-gel Bupivacaine 98.8% [119] Liposome-alginate Benzocaine 63.2% [120] Liposome-PEG Lidocaine 98.8% [73] Cyclodextrin/liposome Quercetin 91.0% [121] Cyclodextrin/liposome Tretinoin 88.7% [122] Cyclodextrin/liposome Curcumin 50.0% [123] Cyclodextrin/PLGA Oxaprozin 62.0% [124] SLN-PLGA-PEG-PLGA [112] related to biohybrid systems for sustained delivery of therapeutic molecules.…”

Section: Innovative Hybrid Lipid Nanoparticles: Solid Lipid Nanopartimentioning

confidence: 99%

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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The use of biomaterials composed of organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery. Drug delivery systems (DDS) have shown several advantages over traditional drug therapy, such as greater therapeutic efficacy, prolonged delivery profile, and reduced drug toxicity, as evidenced by in vitro and in vivo studies as well as clinical trials. Despite that, there is no perfect delivery carrier, and issues such as undesirable viscosity and physicochemical stability or inability to efficiently encapsulate hydrophilic/hydrophobic molecules still persist, limiting DDS applications. To overcome that, biohybrid systems, originating from the synergistic assembly of polymers and other organic materials such as proteins and lipids, have recently been described, yielding molecularly planned biohybrid systems that are able to optimize structures to easily interact with the targets. This work revised the biohybrid DDS clarifying their advantages, limitations, and future perspectives in an attempt to contribute to further research of innovative and safe biohybrid polymer-based system as biomaterials for the sustained release of active molecules.

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Topical Permeation Characteristics of Diclofenac Sodium from NaCMC Gels in Comparison with Conventional Gel Formulations

Cited by 29 publications

References 30 publications

Poly(vinyl alcohol) membranes for adhesion prevention

Poly(vinyl alcohol) membranes for adhesion prevention

Feasibility of carboxymethylcellulose with phenol moieties as a material for mammalian cell-enclosing subsieve-size capsules

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

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