Topical Retinoids in Acne Vulgaris: A Systematic Review

Kolli, Sree S; Pecone, Danielle; Pona, Adrian; Cline, Abigail; Feldman, Steven R.

doi:10.1007/s40257-019-00423-z

Cited by 100 publications

(96 citation statements)

References 31 publications

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“…[4][5][6] The effectiveness of topical retinoids was evaluated in a recent review including a total of 54 scientific papers, that assessed both retinoids as monotherapy and combined as well as comparisons between different topical retinoids. 8 Analysis of these studies showed that the use of topical retinoids is effective and increases in a dose-dependent manner: there are formulations with different concentrations of topical retinoids (adapalene gel may be used in 0.1% or 0.3% formulations), as well as combination with other topical antimicrobial agents (BPO, clindamycin, salicylic acid); the latter combination seems to be more effective than monotherapy. 8 Furthermore, the use of the topical association BPO/retinoid in place of the antibiotic appears to be better to prevent the risk of resistance.…”

Section: T a B L Ementioning

confidence: 99%

“…8 Analysis of these studies showed that the use of topical retinoids is effective and increases in a dose-dependent manner: there are formulations with different concentrations of topical retinoids (adapalene gel may be used in 0.1% or 0.3% formulations), as well as combination with other topical antimicrobial agents (BPO, clindamycin, salicylic acid); the latter combination seems to be more effective than monotherapy. 8 Furthermore, the use of the topical association BPO/retinoid in place of the antibiotic appears to be better to prevent the risk of resistance. Comparative analysis of various studies showed that, in the case of mild acne, any of the topical retinoids could be used, whereas in more severe forms the combination with topical antimicrobials and/ or oral antibiotics was more effective.…”

Section: T a B L Ementioning

confidence: 99%

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An overview of treatment options for mild‐to‐moderate acne based on American Academy of Dermatology, European Academy of Dermatology and Venereology, and Italian Society of Dermatology and Venereology guidelines

Conforti

Chello²,

Giuffrida

et al. 2020

Dermatologic Therapy

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Acne is a common inflammatory skin disorder affecting the pilosebaceous unit. Patients with mild‐to‐moderate acne can be treated with a combination of topical, systemic, and physical therapeutic approaches, with different results depending on patient, disease, and treatment characteristics. Herein we describe and discuss the common and alternative treatment options used for mild‐to‐moderate acne, by comparing three widely distributed guidelines (American Academy of Dermatology, European Academy of Dermatology and Venereology, and Italian Society of Dermatology and Venereology.

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Section: T a B L Ementioning

confidence: 99%

Section: T a B L Ementioning

confidence: 99%

An overview of treatment options for mild‐to‐moderate acne based on American Academy of Dermatology, European Academy of Dermatology and Venereology, and Italian Society of Dermatology and Venereology guidelines

Conforti

Chello²,

Giuffrida

et al. 2020

Dermatologic Therapy

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show abstract

“…5,6,7,8 Topical retinoids are safe and efficacious for the treatment of acne vulgaris. 18 Topical retinoids target the microcomedones, which are the precursor of acne lesions, and are also the preferred drugs for maintenance therapy. 24 Adapalene, is more stable chemically, less photo-labile, and more lipophilic, which enables it to penetrate follicles quickly.…”

Section: Discussionmentioning

confidence: 99%

“…13,14,15,16,17 Topical retinoids are a first-line treatment for acne vulgaris. 18,19 Nadifloxacin, a newer topical fluoroquinolone, is bactericidal, anti-inflammatory and mildly comedolytic. 10 Nadifloxacin inhibits the enzyme DNA gyrase that is involved in bacterial DNA synthesis and replication, thus inhibiting the bacterial multiplication.…”

mentioning

confidence: 99%

A Rational Pharmacotherapeutic Study in Pharmacovigilance: A Comparative Assessment of Safety Between Topical 1% Nadifloxacin and 0.1% Adapalene Combination Therapy and Topical 1% Nadifloxacin and 0.025% Tretinoin Combination Therapy, in Mild to Moderate Acne, in Tertiary Care Hospitals, in India

Hazra¹

2019

jebmh

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BACKGROUNDTopical adapalene and tretinoin, are comedolytic, anti-comedogenic and anti-inflammatory, on RAR (α, β, ℽ) receptors binding. Due to higher chemical stability, lipophilicity and lesser photo-lability, adapalene enables quicker follicular penetration, by lesser anti-AP-1 (c-Jun, c-Fos) and no CRBPII mRNA action, thus producing lesser photosensitivity and no skin irritation, unlike tretinoin; in which, these are reducible by overnight application, combination therapy, slow-release polymers or emollients. Topical nadifloxacin is bactericidal, anti-inflammatory and comedolytic, with inhibitory effect on DNA gyrase, DNA topoisomerase IV and IL-1α, IL-6, IL-8. The Global Alliance to Improve Outcomes in Acne guidelines recommend synergistic and additive combination therapies, which enhance therapeutic efficacy and reduce adverse effects. Due to inadequacy of data, this study was conducted, to compare the safety between topical 1% nadifloxacin and 0.1% adapalene combination therapy and topical 1% nadifloxacin and 0.025% tretinoin combination therapy, in mild to moderate acne, in tertiary care hospitals, in India. METHODSGroups A and B (50 patients each), applied topical 1% nadifloxacin and 0.1% adapalene combination therapy and 1% nadifloxacin and 0.025% tretinoin combination therapy, respectively, over their mild to moderate facial acne lesions, once daily overnight; and adverse effects, like erythema, scaling, dryness, pruritus, burning or stinging, were assessed on 0, 15, 30, 60, 90 days and follow-ups, by Local Irritation Scale. This is a multi-centre, prospective, randomised, open-labelled, comparative, rational pharmacotherapeutic study. Data was statistically analysed, with the calculation of Z values and p values, along with the Z test for proportions. RESULTSIn both groups, no adverse effects were observed, with no statistically significant difference among the observations. CONCLUSIONSThe therapies were well tolerated and safe among both groups.

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“…They should be used in combination with benzoyl peroxide to optimize results in patients. Adapalene has a superior tolerability profile amongst topical retinoids [199]. Developed in response to concerns about the instability of tretinoin, the naphthoic acid derivative adapalene was found in vitro to be photostable and not degraded in the presence of BP.…”

Section: Retinoidsmentioning

confidence: 99%

Acne Protection: Measures & Miseries

2019

ARC Journal of Pharmaceutical Sciences

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Topical Retinoids in Acne Vulgaris: A Systematic Review

Cited by 100 publications

References 31 publications

An overview of treatment options for mild‐to‐moderate acne based on American Academy of Dermatology, European Academy of Dermatology and Venereology, and Italian Society of Dermatology and Venereology guidelines

An overview of treatment options for mild‐to‐moderate acne based on American Academy of Dermatology, European Academy of Dermatology and Venereology, and Italian Society of Dermatology and Venereology guidelines

A Rational Pharmacotherapeutic Study in Pharmacovigilance: A Comparative Assessment of Safety Between Topical 1% Nadifloxacin and 0.1% Adapalene Combination Therapy and Topical 1% Nadifloxacin and 0.025% Tretinoin Combination Therapy, in Mild to Moderate Acne, in Tertiary Care Hospitals, in India

Acne Protection: Measures & Miseries

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