Topical silver sulfadiazine for the prevention of acute dermatitis during irradiation for breast cancer

Abstract

SSD cream reduced the severity of radiation-induced skin injury compared with general skin care alone. Further studies in patients with other types of cancer and also comparing SSD cream with other topical agents are warranted.

Topical Use of Recombinant Human Epidermal Growth Factor (EGF)-Based Cream to Prevent Radiation Dermatitis in Breast Cancer Patients: a Single-Blind Randomized Preliminary Study

“…In patients who applied topical agents such as hyaluronic acid, calendula, trolamine, silver sulfadiazine, and moisturizing durable barrier cream, the reported rates of maximum grade 4, 3, 2, and 1 radiation dermatitis were ranged 0-2%, 0-35%, 41-63%, and 2-50%, respectively. In patients who received general supportive skin care, the reported rates of maximum grade 4, 3, 2, and 1 radiation dermatitis were ranged 0-2%, 3-53%, 32-63%, and 6-58%, respectively (Fisher et al, 2000;Fenig et al, 2001;Pommier et al, 2004;Leonardi et al, 2008;Hemati et al, 2012;Pinnix et al, 2012;Graham et al, 2013). In our study, maximum grade 4 radiation dermatitis did not develop.…”

“…Numerous studies using different compounds such as corticosteroid, aloe vera, hyaluronic acid, sucralfate, biafine, moisturizing durable barrier cream, ascorbic acid, silver sulfadiazine, and calendula have been performed to identify a topical agent that prevents or minimizes the acute radiation dermatitis, but the results of most studies were negative or contradictory (Halperin et al, 1993, Williams et al, 1996, Fisher et al, 2000, Bostrom et al, 2001, Schmuth et al, 2002, Pommier et al, 2004, Merchant et al, 2007, Kirova et al, 2011, Hemati et al, 2012, Pinnix et al, 2012, Graham et al, 2013. A few topical agents demonstrated a superior efficacy in preventing acute radiation dermatitis in randomized phase Ⅲ trials (Schmuth et al, 2002, Pommier et al, 2004, however, there is no general agreement on the gold-standard approach for prevention or minimization of acute radiation dermatitis, and clinical practice seems to be varied across countries and institutions.…”

Phase I study of topical epigallocatechin-3-gallate (EGCG) in patients with breast cancer receiving adjuvant radiotherapy

“…Table 3 lists the randomized studies on the prevention of acute radiation skin reactions in patients with breast cancer receiving radiotherapy in last 5 years. 4,[17][18][19][20][21][22][23][24][25][26][27][28] Randomized controlled studies have generated mostly negative results for use of skin care products in preventing or treating radiation dermatitis. Remarkably, patients receiving topical corticosteroids (mometasone furoate and betamethasone) during radiotherapy might experience reduced acute skin toxicity compared with placebo or moisturizing creams according to the result of three doubleblind studies with a larger population.…”

Acute skin toxicity management in head and neck cancer patients treated with radiotherapy and chemotherapy or EGFR inhibitors: Literature review and consensus

“…Silver sulfadiazine cream was shown to be active in preventing radio-dermatitis [112,113], but its use as prophylactic management is not recommended because of concerns about sensitivity or resistance with overuse [109,114].…”