Topical Sodium Thiosulfate: A Treatment for Calcifications in Hyperphosphatemic Familial Tumoral Calcinosis?

Jost, Jérémy; Bahans, Claire; Courbebaisse, Marie; Tran, Tú-Anh; Linglart, Agnès; Bénistan, Karelle; Lienhardt, Anne; Mutar, Hadile; Pfender, Elodie; Ratsimbazafy, Voa; Guigonis, Vincent

doi:10.1210/jc.2016-1087

Cited by 42 publications

(28 citation statements)

References 25 publications

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“…STS is used for medical conditions, such as calciphylaxis secondary to chronic renal failure, because of its chelating effect on calcium salts (33). STS prevents calci cation by chelating calcium and its acidosis-inducing properties (34).…”

Section: Discussionmentioning

confidence: 99%

Assessment of Sodium Thiosulfate Neutralizing Effect on Micro-hardness of Dentin Treated With Sodium Hypochlorite

Sahebi

Sobhnamayan

Naseri

et al. 2020

Preprint

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Background The aim of this study is to evaluate the ability of sodium thiosulfate (STS) to reverse the adverse effect of sodium hypochlorite (NaOCl) on dentin microhardness. Methods Fifty single-rooted teeth were decoronated and longitudinally sectioned. The samples were divided into a control and four sample groups (n = 20): Normal saline for 15 min as the control group, G1: 2.5% NaOCl for 15 min without an incubation period, G2: 2.5% NaOCl for 15 min, G3: 2.5% NaOCl for 15 min irrigated with normal saline followed by 5% Na2S2O3 for 10 min, G4: Normal saline for 15 min followed by 5% Na2S2O3 for 10 min. All groups except G1 were incubated for 1 week. The microhardness measurements were determined using the Vickers micro-hardness test. Data were analyzed using the Kruskal-Wallis test for pairwise comparisons. A p-value < 0.05 was considered significant. Results All groups showed a significant decrease in the micro-hardness value compared with the control group. NaOCl for 1 week (G2) reduced the micro-hardness of dentine compared with samples, tested immediately after immersion in NaOCl (G1) (p < 0.05). NaOCl alone (G2) or treated with Na2S2O3 (G3) resulted in a significant decrease in microhardness compared with the Na2S2O3 group (G4) (p < 0.05). Conclusions Sodium thiosulfate as a neutralizing agent could not prevent the microhardness downturn caused by sodium hypochlorite

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Section: Discussionmentioning

confidence: 99%

Assessment of Sodium Thiosulfate Neutralizing Effect on Micro-hardness of Dentin Treated With Sodium Hypochlorite

Sahebi

Sobhnamayan

Naseri

et al. 2020

Preprint

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“…In our patient, sodium thiosulfate was used. Th is drug was originally used to treat cyanide poisoning, but has shown effi cacy in several cases of calcinosis cutis (2,6). …”

Section: Metastatic Calcinosis Cutis In End-stage Renal Diseasementioning

confidence: 99%

Metastatic Calcinosis Cutis in End-Stage Renal Disease

Jaeger¹,

Newman²,

Mirkes³

2017

Baylor University Medical Center Proceedings

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“…Although Sevelamer and dietary phosphate restriction lead complete or partial recovery in calcinosis, recurrence have been reported due to possible selfdiscontinuation or ineffectiveness of the drug in a significant proportion of patients. Other agents including acetazolamide, probenocid and topical sodium thiosulfate shown beneficial with variable outcomes (8,(19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

Hyperphosphatemic Familial Tumoral Calcinosis in Two Siblings with a Novel Mutation in GALNT3 gene: Experience from Southern Turkey

Ekinci¹,

Gürbüz²,

Balcı³

et al. 2018

Jcrpe

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Inactivating autosomal recessive mutations in both FGF23, KL and GALNT3 genes lead to a rare disorder, hyperphosphatemic familial tumoral calcinosis (HFTC). Patients with HFTC constantly present hyperphosphatemia and tumor like soft tissue calcifications. Although 78% of patients develop their first symptoms between 2-13 years of age, diagnosis is usually delayed until adulthood. Some individuals with the same genetic defect overlap a condition named Hyperphosphatemic hyperostosis syndrome (HHS). Herein we report two siblings suffering from periarticular warm, hard and tender subcutaneous masses. Subcutaneous calcifications were present on X-ray and biopsy results were consistent with calcinosis in both patients. Laboratory results showed marked hyperphosphatemia and elevated renal tubular phosphate reabsorption, normal renal function tests and serum 25 hydroxyvitamin D levels. Thus, we suspected HFTC and performed next generation sequencing for GALNT3 gene, mostly causative in the literature. A novel homozygote P85Rfs*6 (c.254_255delCT) mutation in GALNT3 gene was identified in both siblings. Our report introduces two new patients to the knowledge about a rare genetic disease and suggests that small deletions in GALNT3 gene may be related with HFTC phenotype. Increased knowledge of physicians about this disease and studying phenotypegenotype correlation with more patients are needed to confirm our suggestion.

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Topical Sodium Thiosulfate: A Treatment for Calcifications in Hyperphosphatemic Familial Tumoral Calcinosis?

Abstract: Topical STS appears to be a promising treatment for ectopic calcifications secondary to HFTC or HHS.

Cited by 42 publications

References 25 publications

Assessment of Sodium Thiosulfate Neutralizing Effect on Micro-hardness of Dentin Treated With Sodium Hypochlorite

Assessment of Sodium Thiosulfate Neutralizing Effect on Micro-hardness of Dentin Treated With Sodium Hypochlorite

Metastatic Calcinosis Cutis in End-Stage Renal Disease

Hyperphosphatemic Familial Tumoral Calcinosis in Two Siblings with a Novel Mutation in GALNT3 gene: Experience from Southern Turkey

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