Topical steroid-damaged skin

Abraham, Anil; Roga, Gillian

doi:10.4103/0019-5154.139872

Cited by 87 publications

(56 citation statements)

References 10 publications

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“…The increased cell density in epidermal layers after steroid treatment seems to contrast with earlier reports on antiproliferative effects of steroids and an overall loss of cells in vitro and in vivo. 36,[41][42][43] It can be assumed that a reduction of the total number of cells occurs with a simultaneously increasing cell density due to the loss of intercellular matrix and ground substance, resulting in an overall reduction of epidermal and dermal tissue volume.…”

Section: Discussionmentioning

confidence: 99%

In vivo characterization of structural changes after topical application of glucocorticoids in healthy human skin

et al. 2017

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Topical glucocorticoids (GC) are known to induce changes in human skin with the potential to develop skin atrophy. Here, atrophogenic effects and subsequent structural changes in the skin after topical application of GC were investigated in vivo. Sixteen healthy volunteers were topically treated daily on the forearms with clobetasol propionate, betamethasone dipropionate, and the petrolatum vehicle for 4 weeks. All treated skin areas and a nontreated control area were examined by ultrasound, optical coherence tomography, confocal laser scanning microscopy, multiphoton tomography (MPT), and resonance Raman spectroscopy at baseline 1 day after last application and 1 week after last application. Investigated parameters included stratum corneum thickness, epidermal, and full skin thickness, keratinocyte size and density, keratinocyte nucleus-to-cytoplasm ratio, skin surface classification, relative collagen and elastin signal intensity, second-harmonic generation-to-autofluorescence aging index of dermis (SAAID), and the antioxidant status of the skin. A reduction in epidermal and dermal skin thickness was observed in GC treated as well as in vehicle-treated and untreated skin areas on the volar forearm. MPT analysis showed an increased epidermal cell density and reduced cell size and nucleus-to-cytoplasm ratio and a significant increase of SAAID after GC treatment indicating a restructuring or compression of collagen fibers clinically being observed as atrophic changes.

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Section: Discussionmentioning

confidence: 99%

In vivo characterization of structural changes after topical application of glucocorticoids in healthy human skin

et al. 2017

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“…Potent topical corticosteroid preparations used for long periods or in excessive quantities may lead to skin atrophy as a well-recognized dermatological risk (18)(19)(20). Corticosteroid-induced skin atrophy is a consequence of collagen synthesis inhibition in connective tissue (18).…”

Section: Discussionmentioning

confidence: 99%

Calcipotriol Plus Betamethasone Versus Betamethasone in Treatment of Scalp Psoriasis in an Iranian Population

et al. 2016

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Background: Psoriasis is one of the most common skin diseases with prevalence rate of 1.4% to 2.9%. The scalp type of this disease is also common. This study was conducted to compare the efficacy and drug complications of single and combination regimens. Methods: Fifty-four patients with scalp psoriasis were randomly divided to 2 groups. In one group (n = 27) betamethasone and calcipotriol (B + C) were administered simultaneously and in the other group (n = 23) betamethasone was administered alone. Clinical status of patients before the treatment, baseline, and 8 weeks after treatment were compared in both groups based on TSS, IGA, and PGA scores. Results: The goal of this study was to evaluate Tss < 1, absence of disease based on IGA, and cleared disease according to PGA. The intensity of the clinical symptoms based on IGA was significantly better in the combination therapy group compared with the monotherapy group at the end of the treatment (P value of 0.04). Furthermore, patients of the calcipotriol group reached a better status compared to the control group (P value of 0.007). Comparison of the basic TSS and TSS at eight weeks showed a significant difference between the two groups after termination of the treatment (P = 0.004). Conclusions: It could be concluded that combination therapy is a reliable and low-complication method compared with the singledrug regimen and is more effective with better efficacy.

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“…However, the incidence of adverse effects due to clobetasol cream was about 42% in this study probably due to d respondents. Study showed hypertrichosis and dermatrophy as common adverse effects due to clobetasol [18,19,20] (Fig. 3).…”

Section: Studies Conducted In Various Countries Includingmentioning

confidence: 97%

The Use of Topical Clobetasol among the Women in Hail Region, Saudi Arabia: A Cross-sectional Study on Knowledge and Practice

Ansari

Palaian

Ibrahim

et al. 2019

JPRI

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Aims: The current study aimed to evaluate female consumers’ knowledge and practice about harmful effects of topical clobetasol applied on the face for cosmetic purposes. Study Design: Cross-sectional study. Place and Duration of Study: Randomly selected community pharmacies, well known cosmetic shops and shopping malls of Hail region, Saudi Arabia from March 2018 to June 2018. Methodology: We included 391 participants who only used ‘clobetasol’ as a topical steroid at the time of interview, responses were collected as per the study tool and analyzed using SPSS for Windows, Version 16.0. Chicago, SPSS Inc.. Results: Relatives (28.1%), friends (25.6%) and community pharmacists (15.6%) contributed significantly towards using topical clobetasol cream. In 86.2% of the cases, the pharmacists who dispensed clobetasol did not inform the consumer about the harmful effects. Purchasing the cream without prescription (P = 0.025) was significantly associated with age. In the study, 41.9 % of the females experienced adverse effects, with the commonest one being hair growth on face (23%) followed by dermatrophy (14.8%); with a significant association with frequency of use (p<0.001). Conclusion: There was haphazard use of topical clobetasol by females and they were unaware of the adverse effects. Over-the-counter availability of topical clobetasol, lack of knowledge about harmful effects, and lack of counseling on its safety profile by community pharmacists and other healthcare professionals are mainly responsible for its misuse and harmful consequences.

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Topical steroid-damaged skin

Cited by 87 publications

References 10 publications

In vivo characterization of structural changes after topical application of glucocorticoids in healthy human skin

In vivo characterization of structural changes after topical application of glucocorticoids in healthy human skin

Calcipotriol Plus Betamethasone Versus Betamethasone in Treatment of Scalp Psoriasis in an Iranian Population

The Use of Topical Clobetasol among the Women in Hail Region, Saudi Arabia: A Cross-sectional Study on Knowledge and Practice

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