Topical tacrolimus does not negatively impact acute skin wound healing

Namkoong, Sun; Chung, Jaewoo; Yoo, Ji-Yeon; Jung, Minyoung; Gye, Jiwon; Kim, Ji Seok; Kim, Jee Young; Ahn, Sung Ku; Park, Byung Cheol; Kim, Myung Hwa; Hong, Soon-Tae

doi:10.1111/exd.12131

Cited by 8 publications

(7 citation statements)

References 24 publications

(30 reference statements)

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“…Some case studies have shown that tacrolimus is effective at healing complex leg ulcers in the context of venous insufficiency or necrobiosis lipoidica when regular treatment strategies have been ineffective 41,42 . Further, a rat-based study with acute cutaneous injury demonstrated that wounds treated with topical tacrolimus versus control (petrolatum) did not differ in healing speed 43 …”

Section: Resultsmentioning

confidence: 99%

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Examining the Association between Immunosuppressants and Wound Healing: A Narrative Review

Appoo,

Christensen,

Somayaji

2024

Adv Skin Wound Care

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Objective To review how different classes of immunosuppressants affect wound healing. Data Sources A literature search was conducted in PubMed, Google Scholar, and the University of Calgary Health Sciences Library. Study Selection The researchers initially screened article titles using key words such as “immunosuppressive medication,” “wound healing,” and “immunosuppression.” Articles in which the title and/or abstract contained these key words, that addressed wound healing related to immunosuppressant medications, and were published after 2000 were included in the review. When human data were not available for an immunosuppressant (class), animal studies were included. Data Extraction The 61 included articles underwent full text review and summarization. Data Synthesis All included studies were summarized descriptively including immunosuppressive mechanism of action, study participants or subjects, and evidence of effects on wound healing. Conclusions Corticosteroids and mechanistic target of rapamycin inhibitors most consistently demonstrate detrimental effects on wound healing. For other classes of immunosuppressants, evidence is limited with varying effects on wound healing described. Larger, high-quality studies are required to better understand the effects of immunosuppressants, including those with new mechanisms of action, to identify those with the most impact on wound healing.

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Section: Resultsmentioning

confidence: 99%

“…41,42 Further, a rat-based study with acute cutaneous injury demonstrated that wounds treated with topical tacrolimus versus control (petrolatum) did not differ in healing speed. 43…”

Section: Polyclonal Antibodiesmentioning

confidence: 99%

Examining the Association between Immunosuppressants and Wound Healing: A Narrative Review

Appoo,

Christensen,

Somayaji

2024

Adv Skin Wound Care

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“…Inhibiting the proliferation of fibroblasts and their tissue migration, the entire protein synthesis of tissue collagen is impaired. Following the same line of research, Nankoong et al (22) studied the effect of the topical tacrolimus therapy in the healing of cutaneous wounds in the backs of mice. They observed that after 3, 7 and 11 days of healing, there was no significant alteration in the healing of tissue between the groups under study, but the group treated with tacrolimus had slightly reduced levels of expression of mRNA of IL-1α and TGF-β.…”

Section: Discussionmentioning

confidence: 99%

Qualitative analysis of the deposit of collagen in bladder suture of rats treated with tacrolimus combined with mycophenolate-mofetil

2014

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ARTICLE INFO ______________________________________________________________ ______________________Purpose: To evaluate the synthesis of type I (mature) and type III (immature) collagen in bladder suture of rats treated with a combination of tacrolimus and mycophenolate mofetil for 15 days. Materials and Methods:Thirty rats were divided into 3 groups: the sham, control and experimental groups. All the animals underwent laparotomy, cystotomy and bladder suture in two planes with surgical PDS 5-0 thread. The sham group did not receive treatment. The control group received saline solution, and the experimental group received 0.1mg/kg/day of tacrolimus with 20mg/kg/day of mycophenolate mofetil, for 15 days. From then on, the tacrolimus was dosed. The surgical specimens of the bladder suture area were processed so that the total type I and type III collagen could be measured by the picrosirius red technique.Results: There was a predominance of type I collagen production in the sham and control groups compared to the experimental group, in which type III collagen was predominant. The production of total collagen did not change. Conclusion:The association of tacrolimus and mycophenolate mofetil in animals qualitatively changes the production of collagen after 15 days with a predominance of type III collagen.

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“…As opposed to topical glucocorticosteroids, which seem to delay wound healing in laboratory animals, tacrolimus appears to increase epithelization, proliferation of fibroblasts and collagen synthesis, making it a good option for long-term treatment, as it does not induce atrophy either [16]. However, a comparative clinical study on the efficacy of topical tacrolimus 0.1% ointment versus triamcinolone acetonide over a follow-up period of 6 months showed no significant differences in efficacy or adverse events [15].…”

Section: Figure 2 Distribution Of Erosive Olp Cases According To Age Group and Gendermentioning

confidence: 99%

Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus

Toader¹,

Mocanu²,

Toader³

et al. 2020

Rev. Chim.

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Tacrolimus, a macrolide with immunosuppressive properties through the inhibition of T-lymphocyte activation, was approved as a second line topical treatment for atopic dermatitis, but has been largely used with beneficial effects in other dermatological conditions that involve a disregulation of the cellular immune response. Oral lichen planus is a T-cell�mediated autoimmune disease in which autocytotoxic CD8+ T cells trigger apoptosis of oral epithelial cells. Our study aimed to analyze the clinical efficacy of tacrolimus 0.03% and 0.1% in orabase as monotherapy on oral erosive lesions of lichen planus, in a group of 20 patients consulted in the Dermatology Clinic of the University C.F. Hospital Iasi during a period of five years. Our results show total or partial remission of oral erosive lesions in most patients at 3 months follow-up. However, after treatment discontinuation relapses are common, which is why intermittent use of topical tacrolimus is needed for longer periods to prevent recurrences. Further large scale studies are necessary to establish efficacy and safety profile of prolonged use of tacrolimus on mucosal membranes, as well as the most appropriate vehicle and concentration.

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Topical tacrolimus does not negatively impact acute skin wound healing

Cited by 8 publications

References 24 publications

Examining the Association between Immunosuppressants and Wound Healing: A Narrative Review

Examining the Association between Immunosuppressants and Wound Healing: A Narrative Review

Qualitative analysis of the deposit of collagen in bladder suture of rats treated with tacrolimus combined with mycophenolate-mofetil

Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus

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