Topical tannic acid application decreases posthemorrhoidectomy pain: a novel idea

El-Mabood, El-Sayed A Abd; Zaher, Nasser A; Ali, Hazem E

doi:10.4103/1110-1121.147586

Cited by 2 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The advantage of cream formulation F could be not only the good antibacterial effect against Gram-positive and Gram-negative bacteria in a relatively short time (microbial inactivation time was 1–6 h) but also many other medical effects of the used compounds. The stimulation of epidermal regeneration, pain reduction, faster wound healing and astringent, antioxidant and antimutagenic properties were attributed to tannic acid (Hupkens et al 1995 ; El-Sayed et al 2014 ). The use of topical tannic acid and quinine in the proposed amount is inexpensive, easily available, entails no allergic reaction and has no systemic effects (El-Sayed et al 2014 ).…”

Section: Discussionmentioning

confidence: 99%

“…The stimulation of epidermal regeneration, pain reduction, faster wound healing and astringent, antioxidant and antimutagenic properties were attributed to tannic acid (Hupkens et al 1995 ; El-Sayed et al 2014 ). The use of topical tannic acid and quinine in the proposed amount is inexpensive, easily available, entails no allergic reaction and has no systemic effects (El-Sayed et al 2014 ). A recent study with topical application of quinine even showed its therapeutic effect in a mouse model of atopic dermatitis (Zhang et al 2021 ), It significantly reduced symptoms like dryness, erythema, oedema and excoriation and thus repaired the skin barrier.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antibacterial activity of plant-derived compounds and cream formulations against canine skin bacteria

Strompfová,

Štempelová,

Wolaschka

2024

Vet Res Commun

View full text Add to dashboard Cite

An urgent need to find alternative antimicrobial compounds effective in the prevention and treatment of skin infections led us to study the inhibitory activity of eight plant-derived bioactive compounds (betulin, curcumin, glycyrrhizic acid, guaiazulene, piperine, quercetin, quinine, tannic acid) against 14 canine skin isolates (11 Gram-positive and three Gram-negative bacteria) selected based on antibiotic resistance and virulence features. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were determined using the broth microdilution method. In detail, the results for the eight different plant compounds showed their inhibitory activity in the concentration range from 0.04 to more than 16 mg/ml (MIC) and from 0.25 to more than 16 mg/ml (MBC). The most potent compounds appear to be tannic acid, followed by quinine and curcumin (MIC 0.04–16.0 mg/ml). The most susceptible strain to the tested agents in general was Bacillus cereus AE13, while Enterococcus faecium AA14 was the most resistant strain (the highest MICs) among the tested bacteria. The two most potent plant-derived compounds (tannic acid and quinine) were tested in mixture in different ratios (1:1, 1:2, 2:1). The lowest MIC and MBC values were observed for the 1:2 ratio, which was used for preparation of creams with different cream bases. One of the cream formulations (cream F) was effective up to 63.0 mg/ml (MIC) with a microbial inactivation time of 1–6 h according to the tested strain. This study provides evidence that some plant-derived compounds could have an antimicrobial effect against canine skin bacteria, the strength of which is bacterial strain dependent.

show abstract

Section: Discussionmentioning

confidence: 99%