1974
DOI: 10.1159/000251929
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Topical Treatment of Cutaneous Candidiasis with 5-Fluorocytosine Compared with Nystatin

Abstract: 30 patients with symmetrical intertriginous candidiasis were treated with 5-fluorocytosine 10% cream and nystatin gel using the paired comparison method. The agents were applied twice daily for 2 weeks. Both compounds were equally effective in eradicating C. albicans and in clinical effectiveness. No side effects were recorded.

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Cited by 4 publications
(7 citation statements)
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“…Nystatin demonstrated clinical cure rates compared to placebo of 76% vs. 28% ( P < 0.01), mycological cure rates of 68% vs. 16% ( P < 0.01) and complete cure rates of 100% vs. 13% . Nystatin therapy was reported similar in efficacy to topical clotrimazole 1%, 5‐fluorocytosine 10%, haloprogin 1% and nystatin–triamcinolone combination therapy and to oral nystatin therapy, while it was tested inferior to mupirocin (Table ).…”
Section: Resultsmentioning
confidence: 98%
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“…Nystatin demonstrated clinical cure rates compared to placebo of 76% vs. 28% ( P < 0.01), mycological cure rates of 68% vs. 16% ( P < 0.01) and complete cure rates of 100% vs. 13% . Nystatin therapy was reported similar in efficacy to topical clotrimazole 1%, 5‐fluorocytosine 10%, haloprogin 1% and nystatin–triamcinolone combination therapy and to oral nystatin therapy, while it was tested inferior to mupirocin (Table ).…”
Section: Resultsmentioning
confidence: 98%
“…Overall, 41 articles investigated topical therapy for cutaneous candidiasis including 2711 patients in 35 RCTs (LE: 1B) and seven prospective blinded or open‐label trials (LE: 2B), of which one article reported two trials in the same article (LE: 1B and 2B) (Table ). In total, 17 different single‐drug and four combination therapies were investigated including clotrimazole (12 studies, LE: 1B or 2B), nystatin (ten studies, LE: 1B or 2B), miconazole (eight studies, LE: 1B), halcinonide–neomycin–amphotericin B (three studies, LE: 1B), ciclopirox (two studies, LE: 1B and 2B), haloprogin (two studies, LE: 1B), halcinonide–neomycin–nystatin (two studies, LE: 1B), naftifine (two studies, LE: 1B), sulconazole (two studies, LE: 1B), mupirocin (two studies, LE: 1B or 2B) and a number of drugs tested in a single study (Table ). In 50% of the studies, the type of Candida was specified by microscopy and/or culture and the majority recorded C. albicans , whereas three studies also found a few patients with C. parapsilosis or C. tropicalis .…”
Section: Resultsmentioning
confidence: 99%
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“…The applied antimycotics were categorized according to the Dutch Pharmacotherapeutic Compass: antimycotic antibiotics (amphotericine-B [36], nystatine [39,40], candidicin [37], pimaricin [30]); imidazoles (ketoconazole [27,28,31], micozanole [57], bifonazole [58], clotrimazole [20,22], econazole [20,22,43,49,51,52], thiabendazole [56], tioconazole [53,55]); triazoles (fluconazole [23]); allylamine (naftifin [45]) and other antimycotic (cyclopyroxolamine [46,54], fluorocytosin [39], dibenzthieen [38], buclosamide [41]).…”
Section: Resultsmentioning
confidence: 99%