Topical treatments for cutaneous warts

Kwok, Chun Shing; Gibbs, Sam; Bennett, Cathy; Holland, Richard; Abbott, Rachel

doi:10.1002/14651858.cd001781.pub3

Cited by 223 publications

(242 citation statements)

References 109 publications

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“…10 Two important trials published within the last few years 11,12 are included in a recently updated Cochrane review. 13 Bruggink et al 11 studied 250 patients in primary care who were randomized to one of three treatment regimens: SA 40% ointment, fortnightly cotton-bud cryotherapy, or no treatment for 13 weeks. The cure rates for all sites combined were 15%, 49% and 8%, respectively; subgroup cure rates were: hand warts, 17%, 46% and 7%, respectively, and plantar warts, 33%, 30% and 23%, respectively.…”

Section: Destructive Treatmentsmentioning

confidence: 99%

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British Association of Dermatologists' guidelines for the management of cutaneous warts 2014

et al. 2014

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Section: Destructive Treatmentsmentioning

confidence: 99%

“…Two recently published trials 11,12 have provided much betterquality data than previously and have compared cryotherapy directly with SA. 13 As discussed in the section on SA (section 8.2.1.a. ), cryotherapy gave equivalent or improved rates of cure when compared with SA.…”

Section: 29mentioning

confidence: 99%

British Association of Dermatologists' guidelines for the management of cutaneous warts 2014

et al. 2014

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“…17 Another factor may be attributed to the differences in cure rates is the duration of warts before treatment. 14,15,20,21 In this study, a significant association was found between duration of warts before treatment and cure rates. There was also a difference in the age of the populations in our study in comparison to other studies which may have a rule in differences in cure rates.…”

Section: Data Management and Statistical Analysismentioning

confidence: 51%

“…difference, except for one trial in the study showed better outcome of cryotherapy than placebo and salicylic acid. 20 The differences in cure rate from other studies could be attributed `to the different population recruited to the study and difference in the study design. In the current study, we excluded mosaic warts and those who had been treated within the past six months while another trial included both types of plantar wart (mosaic and non-mosaic verruca) and also did not exclude patients who took the previous treatment.…”

Section: Data Management and Statistical Analysismentioning

confidence: 95%

Comparative study between cryotherapy and salicylic acid in the treatment of plantar warts in Erbil - Iraq

Muhamad¹,

Sulaiman²

2018

ZJMS

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Abstract* Rizgary Teaching Hospital, Erbil, Iraq. IntroductionPlantar warts, also known as verruca plantaris, are benign epithelial tumors, caused by the human papillomavirus (HPV) occurring on the soler toes of the feet. On the soles, these are often painful from pressure when walking, due to their deep inward growth. Plantar warts are common in older children and young adults, accounting for 30% of cutaneous warts. Plantar warts are caused by HPV-1, 2, 4, 27 or 57. [1][2][3][4] HPVs form a large group of closely related viruses, distinguished one from another on the basis of their DNA. To date, about 100 types have been recognized and characterized. All papillomavirus types have a tropism for stratified squamous epithelial cells, but they vary in their specificity for different anatomical sites. Papillomaviruses are small 50 to 55-nm-diameter DNA viruses that infect squamous epithelia, causing cell proliferation. The commonest effect of HPV infection is the development of warts (verrucae).2 A plantar wart at first appears as a small shining 'sago-grain 'papule, but soon assumes the typical appearance of a sharply defined, rounded lesion, with a rough, keratotic surface surrounded by a smooth collar of a thickened horn. Individuals may be affected by a single or numerous lesions.2 The soft, pulpy cores are surrounded by a firm, horny ring. Over the surface of the plantar wart, most clearly if the top is shaved off, multiple small black points may be seen that represent dilated capillary loops within elongated dermal papillae.1 Pain is a common but variable symptom. It may be severe and disabling, but may be absent, and many warts are discovered only on routine inspection. 2Background and objective: Plantar warts are hard, grainy growths that usually appear on the heels or balls of feet. Plantar warts are caused by the human papillomavirus, usually self-limiting, but treatment is generally recommended to lessen symptoms, decrease duration, and reduce transmission. The study aimed to evaluate the clinical effectiveness of topical 40% salicylic acid in comparison to cryotherapy in the treatment of plantar wart. Methods: This study was conducted from March 2015 to January 2016 on 70 patients with plantar wart who attended the consultation clinic of dermatology department in Rizgary teaching hospital. Patients were randomly allocated to two groups: cryotherapy treatment with liquid nitrogen every two or three weeks and self-application of salicylic acid daily. Results: Sixty patients aged 12 to 60 years were included in the analysis at 13 weeks. Cure rates were 66.7% in the cryotherapy group and 80% in the salicylic acid group. A significant association was found between the duration of wart before treatment and cure rates (P <0.001). Conclusion:No difference in effectiveness between cryotherapy and topical salicylic acid 40% in the treatment of plantar warts was found.

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“…Different treatments for warts may be considered, including prescription drugs, over-the-counter medications and physical destructive methods, but as yet no treatment has been proven to be 100% effective in achieving complete remission. Kwok et al have recently reported the results of an updated systematic review of available randomized controlled trials (RCTs) on CWs [1].…”

mentioning

confidence: 99%