Topical treatments for fungal infections of the skin and nails of the foot.

Crawford, Fay; Hollis, Sally

doi:10.1002/14651858.cd001434.pub2

Cited by 133 publications

(98 citation statements)

References 94 publications

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“…ciclopiroxolamine after 48 weeks. This might be due to a lack of compliance because of repetitive daily applications over months [9]. The number of treatment sessions might be the great advantage of the laser treatment; they are short, and the dermatologist can ensure the treatment is performed accurately.…”

Section: Discussionmentioning

confidence: 99%

1,064-nm Diode Laser Therapy of Onychomycosis: Results of a Prospective Open Treatment of 82 Toenails

Renner

Grüsser

Sticherling³

2015

Dermatology

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Background: Onychomycosis is one of the most prevalent nail disorders in adults, where conventional topical therapy is often protracted and in most cases ineffective. On the other hand, systemic/oral therapy is not suitable for all patients and might be associated with relevant side effects. Therefore, laser therapy can be used as an alternative to or extension of existing treatment protocols. Objectives: We used diode laser treatment for onychomycosis to evaluate the efficacy of this treatment as single therapy as well as in combination with an ongoing antimycotic treatment. Methods: We used a 1,064-nm diode laser (FOX Laser, ARC Laser GmbH, Germany) in pulse mode with a spot size of 4 mm. The laser's settings were: 8 W, with a pulse duration of 80 ms and a repetition rate of 5.6 Hz; the energy fluence/pulse was 5.1 J/cm², and a total energy of 250-500 J for large and/or thickened nails (digit I), 120-200 J for medium nails (digits II-IV) and 60-120 J for small and/or very thin nail plates (digit V) was counted in the laser display. Two to three passes where applied continuously over the entire area of the nail (nail plate, nail folds and eponychium) in a grid pattern. Eighty-two affected toenails were treated at least twice every 8 weeks; all nails treated were clinically diagnosed as onychomycosis. The evaluation of the treated nails was conducted by two dermatologists, initially by semiquantitative visual examination, followed by evaluation with the Onychomycosis Severity Index (OSI). In addition, the patients were asked to state their satisfaction with the treatment and its results in a written questionnaire. Results: All nails showed an improvement ranging between 14 and 56% including the analytical evaluation scale (OSI). Two dermatologists evaluated 34 nails. Both reported significant improvement and/or good clinical improvement, which corresponds to about 41% for both evaluations. The mean OSI of all patients was 18.9/19.9 before treatment which changed to 14.3/14.8 after treatment. This corresponds to an improvement of about 25% (-4.6/-5.1) compared to the initial value. Specifically the subgroup with positive antimycotic culture and no additional antimycotic treatment showed an improvement of about 25%. This improvement can be attributed to the effect of the diode laser treatment. When evaluating the OSI of all nails, it appears that about 15-20% of the severe OSIs improved and changed to a moderate level, while a similar portion of patients with moderate onychomycosis improved to mild onychomycosis. Patient satisfaction was measured to an average value of 4.6 out of a maximum of 10 points. About 60% of the treated patients would recommend the treatment to their family members or friends. Conclusion: This investigation demonstrated that diode laser treatment of onychomycosis provides acceptable results with minimal to no side effects. Further clinical evaluations could help to establish better therapy protocols, especially for those patients who had no benefit from the laser treatment, or co...

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Section: Discussionmentioning

confidence: 99%

1,064-nm Diode Laser Therapy of Onychomycosis: Results of a Prospective Open Treatment of 82 Toenails

Renner

Grüsser

Sticherling³

2015

Dermatology

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“…Mild to moderate tinea pedis usually responds to topical antifungal agents. A meta-analysis of 11 randomized trials concluded that treatment with topical allylamines (terbinafine, naftifine, butenafine) results in a slightly higher cure rate than topical imidazoles (ketoconazole, econazole, clotrimazole) [60]. Chronic, extensive, or refractory disease is treated with a topical agent plus oral terbinafine (250 mg daily for 2 weeks; 86 % mycologic cure), itraconazole (200 mg twice daily for 1 week; 67 % mycologic cure), or fluconazole (150 mg once weekly for 2-6 weeks; 77 % clinical cure) [61][62][63][64].…”

Section: Tinea Pedismentioning

confidence: 99%

Skin Conditions of Baseball, Cricket, and Softball Players

et al. 2013

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Each year in the United States over 80 million people participate in bat-and-ball sports, for example baseball and softball. Cricket, the world's second most popular sport, is enjoyed by hundreds of millions of participants in such countries as India, Pakistan, Australia, New Zealand, Bangladesh, South Africa, West Indies, Sri Lanka, United Kingdom, and Zimbabwe. Although any player can develop skin disease as a result of participation in these bat-and-ball sports, competitive team athletes are especially prone to skin problems related to infection, trauma, allergy, solar exposure, and other causes. These diseases can produce symptoms that hinder individual athletic performance and participation. In this review, we discuss the diagnosis and best-practice management of skin diseases that can develop as a result of participation in baseball, softball, and cricket.

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“…Nail infections, however, require prolonged application (at least one year) and studies are scarce. [9] Resistance of the dermatophytes…”

Section: Antifungal Activitymentioning

confidence: 99%

“…Kolbe electrolysis od dicarboxylic acids 149 and UA 1. 710 www.chemsuschem.org 9 Other applications UA was evaluated as a thermal storage material absorbed in wallboard. The purpose was to diminish heat fluctuations in buildings by modifying the wall material with 20-30 % organic material.…”

Section: Undecylenic Acid In Food Chemistrymentioning

confidence: 99%

Undecylenic Acid: A Valuable and Physiologically Active Renewable Building Block from Castor Oil

2009

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A lot of attention is currently being paid to the transition to a biobased economy. In this movement, most efforts concentrate on the development of bioenergy applications including bioethanol, biodiesel, thermochemical conversion of biomass, and others. However, in the energy sector other nonbiomass alternatives are known, whereas no valuable alternatives are available when thinking about chemical building blocks. Therefore, it is also essential to develop new routes for the synthesis of bio-based chemicals and materials derived thereof. Such intermediates can originate either from plants or from animals. Castor oil is a non-edible oil extracted from the seeds of the castor bean plant Ricinus communis (Euphorbiaceae), which grows in tropical and subtropical areas. Globally, around one million tons of castor seeds are produced every year, the leading producing areas being India, PR China, and Brazil.2 10-Undecenoic acid or undecylenic acid is a fatty acid derived from castor oil that, owing to its bifunctional nature, has many possibilities to develop sustainable applications.

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Topical treatments for fungal infections of the skin and nails of the foot.

Abstract: Topical treatments for fungal infections of the skin and nails of the foot..

Cited by 133 publications

References 94 publications

1,064-nm Diode Laser Therapy of Onychomycosis: Results of a Prospective Open Treatment of 82 Toenails

1,064-nm Diode Laser Therapy of Onychomycosis: Results of a Prospective Open Treatment of 82 Toenails

Skin Conditions of Baseball, Cricket, and Softball Players

Undecylenic Acid: A Valuable and Physiologically Active Renewable Building Block from Castor Oil

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