Topical treatments for fungal infections of the skin and nails of the foot

Crawford, Fay; Hart, Rachel; Bell-Syer, Sally EM; Torgerson, DJ; Young, Philip J.; Russell, Ian

doi:10.1002/14651858.cd001434

Cited by 43 publications

(72 citation statements)

References 60 publications

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“…Topical agents approved for the treatment of mild to moderate fungal nail infection without matrix involvement include formulations based on ciclopirox or amorolfine. However, the rates of efficacy reported for these formulations are generally low (5), and this is considered to be due to poor penetration of the antifungals through the nail (18). Consequently, there is still a need for new topical treatments which can penetrate the nail sufficiently for antifungal activity at the site of infection in the nail bed.…”

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confidence: 99%

Evaluation of the Morphological Effects of TDT 067 (Terbinafine in Transfersome) and Conventional Terbinafine on Dermatophyte Hyphae In Vitro and In Vivo

Ghannoum

Isham

Henry

et al. 2012

Antimicrob Agents Chemother

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TDT 067 is a novel, carrier-based dosage form of terbinafine in Transfersome (1.5%) formulated for topical delivery of terbinafine to the nail, nail bed, and surrounding tissue. We examined the effects of TDT 067 and conventional terbinafine on the morphology of dermatophytes. Trichophyton rubrum hyphae were exposed to TDT 067 or terbinafine (15 mg/ml) and examined under white light, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Subungual debris from patients treated with TDT 067 in a clinical trial was also examined. Exposure of T. rubrum hyphae to TDT 067 led to rapid and extensive ultrastructural changes. Hyphal distortion was evident as early as 4 h after exposure to TDT 067. After 24 h, there was complete disruption of hyphal structure with few intact hyphae remaining. Exposure to terbinafine resulted in morphological alterations similar to those seen with TDT 067; however, the effects of TDT 067 were more extensive, whereas a portion of hyphae remained intact after 24 h of exposure to terbinafine. Lipid droplets were observed under TEM following 30 min of exposure to TDT 067, which after 24 h had filled the intracellular space. These effects were confirmed in vivo in subungual debris from patients with onychomycosis who received topical treatment with TDT 067. The Transfersome in TDT 067 may potentiate the action of terbinafine by delivering terbinafine more effectively to its site of action inside the fungus. Our in vivo data confirm that TDT 067 can enter fungus in the nail bed of patients with onychomycosis and exert its antifungal effects.

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confidence: 99%

Evaluation of the Morphological Effects of TDT 067 (Terbinafine in Transfersome) and Conventional Terbinafine on Dermatophyte Hyphae In Vitro and In Vivo

Ghannoum

Isham

Henry

et al. 2012

Antimicrob Agents Chemother

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“…Diagnosis is based on history and clinical presentation, and confirmed by KOH microscopy of lesion scrapings or nail clippings (depending on the affected anatomical system) and/or fungal cultures. Most tinea infections can be managed with topical antifungal cream, such as azoles (econazole, ketoconazole) and allylamines (terbinafine) [15]. Oral treatment, such as terbinafine, itraconozole, or fluconazole, may be required in patients with persistent or widespread infections.…”

Section: Discussionmentioning

confidence: 99%

Differentiating hand-foot syndrome from tinea in patients receiving chemotherapy

2016

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“…The MIC range of ciclopirox for the T. mentagrophytes, T. tonsurans, T. rubrum, Microsporum canis, M. gypseum, and E. floccosum strains was 0.03 to 0.25 g/ml. In addition, the available topical agents are not regarded as effective for the treatment of onychomycosis (9).…”

Section: Discussionmentioning

confidence: 99%

Activity of TDT 067 (Terbinafine in Transfersome) against Agents of Onychomycosis, as Determined by Minimum Inhibitory and Fungicidal Concentrations

et al. 2011

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Topical treatments for fungal infections of the skin and nails of the foot

Cited by 43 publications

References 60 publications

Evaluation of the Morphological Effects of TDT 067 (Terbinafine in Transfersome) and Conventional Terbinafine on Dermatophyte Hyphae In Vitro and In Vivo

Evaluation of the Morphological Effects of TDT 067 (Terbinafine in Transfersome) and Conventional Terbinafine on Dermatophyte Hyphae In Vitro and In Vivo

Differentiating hand-foot syndrome from tinea in patients receiving chemotherapy

Activity of TDT 067 (Terbinafine in Transfersome) against Agents of Onychomycosis, as Determined by Minimum Inhibitory and Fungicidal Concentrations

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