Topical treatments for hypertrophic scars

Zurada, Joanna M.; Kriegel, David; Davis, Ira C.

doi:10.1016/j.jaad.2006.03.022

Cited by 168 publications

(117 citation statements)

References 47 publications

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“…At present, more consistent view about the Hyperplasia scar is that the Hyperplasia scar is caused by excessive fibroblast proliferation and the imbalance of the extracellular matrix's synthesis and degradation [2]. There are many methods for the treatment of the Hyperplasia scar, such as pressure therapy, intralesional corticosteroids, radiation therapy and topical medications [3]. Pressure therapy is one of the most effective methods to prevention and treatment of Hyperplasia scar and this method is easy to operate, having an exact curative effect, low price, and is noninvasive treatment [4,5].…”

Section: Introductionmentioning

confidence: 99%

Compression Sleeves Design Based on Laplace Laws

Zhao¹,

Li²,

Yu³

et al. 2017

JTEFT

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Compression sleeves are very important to the prevention and control of human limb hyperplasia scaring. The garment pressure is the key determinant of the curative effect, and one of the key factors which influence this value is the precision of Compression sleeves design. In order to study the design and performance of Compression sleeves via relatively simple but accurate methodologies, different deformation formulas of Laplace law were summarized and analyzed. Firstly, it was found that both of the deformation formulas of Laplace law proposed by Maklewska and Leung respectively were based on the principle that the arm radius was calculated by the arm circumference, furthermore, the arm radius, fabric tensile index and the preset clothing pressure were substituted into the Laplace law formula, and the sizes of the Compression sleeves could be calculated. Since the design methods proposed above were easier to implement in practical production, Compression sleeves were designed and manufactured based on the deformation formulas of Laplace law, and garment pressures were tested and compared with the preset pressures. Experimental results showed that garment pressures of the Compression sleeves which were designed based on the Maklewska Laplace law within the scope of the required pressure value, so this deformation could be used for designing the Compression sleeves accurately. However, the sizes of the Compression sleeves which were calculated based on the Leung Laplace law were too small to put on, so the formula of Leung Laplace law was not suitable for designing the Compression sleeves.

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Section: Introductionmentioning

confidence: 99%

Compression Sleeves Design Based on Laplace Laws

Zhao¹,

Li²,

Yu³

et al. 2017

JTEFT

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“…Some scars heal well, which leads to the formation of an imperceptible thin line, others are susceptible to the hypertrophy of a scar, and in the worst case, to the conversion into a keloid. A disturbed scarring process causes functional, aesthetic, and psychological disorders in the patient [1,3]. Frequent symptoms associated with hypertrophic scars and keloids are: itching, pain, and restriction of movement, especially in the vicinity of the joints [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Pressotherapy of a postoperative scar with the application of non-sterile silicone dressings in a 56-year-old woman treated for breast cancer in the Holycross Cancer Centre in Kielce

Macek¹,

Terek-Derszniak²,

Lipińska³

et al. 2015

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Scarring is a natural process of wound healing. In some cases, however, there is formation of hypertrophic scars and keloids that are the result of collagen decomposition and synthesis. A disturbed scarring process causes functional, aesthetic, and psychological disorders in the patient. Silicone dressings in the form of plasters or gel are used in the treatment of hypertrophic scars and keloids. A case of pressotherapy of a postoperative scar with the use of non-sterile silicone dressings in a 56-year-old patient treated for breast cancer is described herein. The use of a 2-month pressotherapy of the scar resulted in an improvement in all the assessed parameters. Pressotherapy of the postoperative scar in the patient after mastectomy proved to be an effective and promising method. However, the methods of the scar assessment before and after treatment need objectivity.

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“…These preventions usually include topical medical application, cryotherapy, the use of silicone gel sheets, the injection of steroids, radiotherapy and an early surgical procedure for wound closure. Recent reports have introduced the use of extracts from natural sources such as plant extracts in an attempt to correct these problems (Muangman et al, 2006;Stella et al, 2008;Zurada et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of the combination of herbal extracts and a silicone derivative in the treatment of hypertrophic scar formation after burn injury

Muangman¹,

Aramwit

Palapinyo³

et al. 2011

Afr. J. Pharm. Pharmacol.

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The development of hypertrophic scars is an unsolved problem in the process of wound healing. The objective of this research was to study the efficacy of the combination of herbal extracts and a silicone derivative in a gel preparation (Cybele ® Scagel) on the treatment of deep second degree burns after complete epithelialization. Sixty-three patients were enrolled in this study. One wound area larger than 10 × 10 cm was selected from each patient to receive treatment with Cybele ® Scagel. Patients were observed for pigmentation, pliability, pain and itching for 0, 2, 4, 8, 12, 16, 20 and 24 weeks after treatment. Their data and wound characteristics were collected during each visit using the Vancouver scar scale. After 24 weeks, all scales (pigmentation, pliability, pain and itching) were significantly lower in the sites treated with Cybele ® Scagel compared with the previous time points (p< 0.05). However, vascularity and height scale were not significantly different (p> 0.05). One patient was excluded at week 2 because of moderate itching at the wound site, which could have interfered with the evaluation. The application of Cybele ® Scagel might have some beneficial effects for prevention of hypertrophic scar formation after partial thickness burn injuries.

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Topical treatments for hypertrophic scars

Cited by 168 publications

References 47 publications

Compression Sleeves Design Based on Laplace Laws

Compression Sleeves Design Based on Laplace Laws

Pressotherapy of a postoperative scar with the application of non-sterile silicone dressings in a 56-year-old woman treated for breast cancer in the Holycross Cancer Centre in Kielce

Efficacy of the combination of herbal extracts and a silicone derivative in the treatment of hypertrophic scar formation after burn injury

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