Topical Tretinoin (Retinoic Acid) Therapy for Hyperpigmented Lesions Caused by Inflammation of the Skin in Black Patients

Bulengo-Ransby, Stella M.; Griffiths, Christopher E.M.; Kimbrough-Green, Candance; Finkel, Lawrence J.; Hamilton, Ted A.; Ellis, Charles N.; Voorhees, John J.

doi:10.1056/nejm199305203282002

Cited by 188 publications

(99 citation statements)

References 14 publications

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“…Prepuce Histology diminished intensity of hyperpigmentation seen in mucosal grafts. Hyperpigmentation may be solely the result of an inflammatory response, which was proposed previously for skin grafts, 21,22 although this assumption has been opposed by other authors. 23,24 It is clear that the exact mechanisms influencing this particular feature deserve further studies.…”

Section: Tuncali Et Almentioning

confidence: 94%

Histologic Characteristics of the Human Prepuce Pertaining to its Clinical Behavior as a Dual Graft

Tuncali¹,

Bingul²,

Talim³

et al. 2005

Annals of Plastic Surgery

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The aim of this study was to investigate the unique histologic structure of the normal human prepuce, paying particular attention to the resemblance and dissimilarities between the inner (ie, mucosa) and outer (ie, skin) layers. Histologic sections were stained using hematoxylin-eosin and Van Gieson stains. Transmission electron microscopy was used to evaluate the ultrastructure. Dense capillary networks can be observed in both the upper and lower dermal zones. The dermis lacks a dense collagenous zone. Melanocytes could not be observed in the mucosa. Elastin fibers and bundles were very abundant and dense. Early edema formation can be explained by the loose character of the dermal structure. Better graft "take" in mucosal grafts may be the result of the dense vascular dermal network. Mild hyperpigmentation can be explained by the limited number of melanocytes. However, this can also be observed in mucosal grafts, despite the absence of melanocytes. This may be solely the result of inflammatory hyperpigmentation, which can be seen in skin grafts. The abundance of elastin fibers in the prepuce may be the reason behind the superior wound contraction inhibition.

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Section: Tuncali Et Almentioning

confidence: 94%

Histologic Characteristics of the Human Prepuce Pertaining to its Clinical Behavior as a Dual Graft

Tuncali¹,

Bingul²,

Talim³

et al. 2005

Annals of Plastic Surgery

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“…However, the hydroquinone group had a statistically superior reduction in hyperpigmentation at 6 months. These agents, in addition to rigorous sun protection, are thought to suppress melanocytes (Bulengo-Ransby et al, 1993) prior to the peel and hence prevent hyperpigmentation. Some recommend continuing this regimen post-peel as well for maximal efficacy, and a similar approach is used to treat hyperpigmentation resulting from a peel.…”

Section: Discussionmentioning

confidence: 99%

Chemical burn following 50% trichloroacetic acid for acne: Presentation of a case and a focused review

Liu

Khachemoune

Rashid³

2016

Journal of Dermatology & Dermatologic Surgery

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Background: Chemical peels are widely used minimally invasive procedures with both cosmetic and medical indications. Although known for their general safety and efficacy, peels can rarely result in significant complications.Objective: Here we report the first case in the peer-reviewed literature of chemical burn from erroneous home use of 50% trichloroacetic acid.Methods: A focused literature review was performed of complications relating to chemical peels. Results: Chemical burns from trichloroacetic acid peels are rare. To our knowledge, this is the first such case reported with supporting histopathological data.Conclusions: Physicians must be aware of the potential complications of chemical peels, prevention strategies, and treatment modalities. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).

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“…This further confirms what has been found in previous PIH and melasma studies, where histology was found to be ineffective, but spectroscopy was effective in quantifying pigmented skin from normal skin. 19,20 Thus, the correlation between clinical and spectroscopic evaluation suggests that these two components can be part of future clinical research to assess the efficacy of various interventions done to treat or prevent PIH.…”

Section: Discussionmentioning

confidence: 99%

Anin vivomodel for postinflammatory hyperpigmentation: an analysis of histological, spectroscopic, colorimetric and clinical traits

et al. 2015

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Topical Tretinoin (Retinoic Acid) Therapy for Hyperpigmented Lesions Caused by Inflammation of the Skin in Black Patients

Abstract: Topical application of tretinoin significantly lightens post-inflammatory hyperpigmentation and, to a clinically minimal but statistically significant degree, lightens normal skin in black persons.

Cited by 188 publications

References 14 publications

Histologic Characteristics of the Human Prepuce Pertaining to its Clinical Behavior as a Dual Graft

Histologic Characteristics of the Human Prepuce Pertaining to its Clinical Behavior as a Dual Graft

Chemical burn following 50% trichloroacetic acid for acne: Presentation of a case and a focused review

Anin vivomodel for postinflammatory hyperpigmentation: an analysis of histological, spectroscopic, colorimetric and clinical traits

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