Topical Use of a Silymarin-Based Preparation to Prevent Radiodermatitis

Abstract

Silymarin-based cream Leviaderm(®) may be a promising and effective treatment for the prevention of acute skin lesions caused by RT of breast cancer patients. To confirm the results of this nonrandomized, observational trial, this component should be tested in larger multicenter studies in this setting.

Prophylaxis of Acute Radiation Dermatitis with an Innovative FDA-Approved Two-Step Skin Care System in a Patient with Head and Neck Cancer Undergoing a Platin-Based Radiochemotherapy: A Case Report and Review of the Literature

“…Besides the widely spread agents mentioned above there are also topical agents rather rarely used but showing encouraging results with potential benefits in clinical testing like hyaluronic acid [18], urea [19] or silymarin [20]. On the other side there are even more approaches with negative results or a very limited level of evidence like biafine [21], sucralfate [22], different dressings [23,24] or LED photomodulation [25] to name only a few.…”

A Pilot Study Using the Chinese Herbal Paste Liu-He-Dan to Manage Radiodermatitis Associated with Breast Cancer Radiotherapy

“…[8][9][10] . Physical methods can also be adopted to reduce wound exudation, thus keeping it dry to promote healing.…”

Treatment of radiation-induced mucocutaneous toxicity

“…Th e benefi cial eff ects of silymarin-based cream in reducing the rate of objective and subjective skin toxicity have been confi rmed in one prospective trial evaluating 101 breast cancer patients [1]. Besides local agents modern radiation treatment techniques remain the most promising intervention in reducing the degree of skin reaction.…”

“…Th ese include large irradiation volume, concomitant systemic treatment and comorbidities such as diabetes or hypertension. Treatment areas commonly sited as having a higher incidence of side-eff ects are those of head and neck, breast and chest wall fi elds and regions containing skin folds [1].…”