Topical Wound Healing Activity of Myricetin Isolated from Tecomaria capensis v. aurea

Abstract

Wounds and burn injury are major causes of death and disability worldwide. Myricetin is a common bioactive flavonoid isolated naturally from the plant kingdom. Herein, a topical application of naturally isolated myricetin from the shoots of Tecomaria capensis v. aurea on excisional wound healing that was performed in albino rats. The wounded rats were treated every day with 10 and 20% myricetin for 14 days. During the experiment, the wound closure percentage was estimated at days 0, 7, and 14. Effects of myricetin on the inflammatory cytokines (tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and cluster of differentiation 68 (CD68) in the serum were evaluated using immunosorbent assay kits. The percentage of wound closure and contraction was delayed in wounded rats (67.35%) and was remarkably increased after treatment of wounded rats with myricetin; the treatment with 20% myricetin was the most potent (98.76%). Histological findings exhibited that 10% myricetin caused the formation of a large area of scarring at the wound enclosure and stratified squamous epithelium without the formation of papillae as in the control group. Treatment with 20% myricetin exhibited less area of scarring at the wound enclosure as well as re-epithelialization with a high density of fibroblasts and blood capillaries in the wound. Level elevations of serum pro-inflammatory cytokines, IL-1β, and TNF-α and macrophage CD68 were decreased in wounded rats treated with myricetin. Thus, it can be suggested that the enhancements in inflammatory cytokines as well as systemic reorganization after myricetin treatment may be recommended to play a crucial part in the promotion of wound healing. The findings suggest that treatment with a higher dose of myricetin was better in improving wound curing in rats. It could serve as a potent anti-inflammatory agent and can be used as an adjunctive or alternative agent in the future.

Ointment-Based Combination of Dittrichia viscosa L. and Marrubium vulgare L. Accelerate Burn Wound Healing

“…It has been proven that quercetin performs a crucial action on the collagen matrices for dermal wound healing processes [ 64 ], and the effectiveness of ferulic acid in the healing process was also proved [ 65 ]. Other flavonoids, such us myricetin, naringenin, isoliquiritin, curcumin, and apigenin, were also reported to possess wound healing activity [ 66 , 67 ].…”

A Comprehensive Review of Natural Compounds for Wound Healing: Targeting Bioactivity Perspective

“…From the literature search, we collected a list of 137 research articles [ 30 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 …”

“…Myricetin (Myr) is a flavonoid that has been reported for wound healing [ 47 , 59 ]. Myricetin is present in many fruits and has many biochemical properties such as antioxidant, anti-allergic, anti-inflammation, and immunomodulatory function [ 178 , 179 , 180 , 181 ].…”

“…Elshamy et al isolated myricetin from Tecomaria capensis v . aurea and examined its wound healing ability in albino rats [ 47 ]. Myr affects inflammatory cytokines such as tumor necrosis factor-α (TNF-α), cluster of differentiation 68 (CD68), as well as interleukin-1β (IL-1β).…”

Effect of the natural flavonoids myricetin and dihydromyricetin on the wound healing process in vitro

“…Further, MYR prevents activation of the NF-κB signalling pathway (Grenier et al, 2015). Elshamy et al (2020) recently published a study carried out on albino rats. The rats were injured and treated with 10% and 20% MYR for 14 days to indicate its healing properties.…”