Topical Δ9-tetrahydrocannabinol in hypertensive glaucomas

Merritt, John C.; Olsen, James L.; Armstrong, John R.; McKinnon, SJ

doi:10.1111/j.2042-7158.1981.tb13699.x

Cited by 53 publications

(27 citation statements)

References 2 publications

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“…THC or marijuana decreased intraocular pressure whether administered orally, topically, or intravenously, with no major tolerance to their effect reported (Shapiro, 1974;Purnell and Gregg, 1975;Cuendet et al, 1976;Hepler et al, 1976;Brown et al, 1977;Merritt et al, 1980Merritt et al, , 1981a. Most of these studies also reported various systemic side effects, such as hypotension, tachycardia, euphoria, and dysphoria, as well as other ocular effects, such as changes in pupil size, decreased tear production, and conjunctival hyperemia.…”

Section: E Eye Disorders (Glaucoma and Retinopathy)mentioning

confidence: 89%

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

2006

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Section: E Eye Disorders (Glaucoma and Retinopathy)mentioning

confidence: 89%

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

2006

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“…Even at very low doses the active compounds produce some or all of the following side effects: euphoria, dysphoria, anxiety, postural hypotension, mild analgesia, tachycardia, and conjunctival hyperemia (145)(146)(147).…”

Section: Cannabinoidsmentioning

confidence: 99%

A Synopsis of Recent Developments in Antiglaucoma Drugs

McLaughlin¹,

Chiou²

1985

Journal of Ocular Pharmacology and Therapeutics

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Open-angle glaucoma is treated primarily with drugs, some of which have been used clinically for years. These drugs include: 1) cholinergic agonists that increase aqueous humor outflow, 2) adrenergic agonists and antagonist that affect both aqueous humor formation and outflow, and 3) carbonic anhydrase inhibitors that decrease aqueous humor formation.Several new classes of drugs are being tested for efficacy and mechanism of action. They include: 1) the D-isomer of timolol that reduces aqueous humor formation without producing adrenergic blockade, 2) dopaminergic agonists and antagonists, including bromocriptine and butyrophenones that reduce intraocular pressure, and 3) cannabinoids that reduce aqueous humor formation and increase outflow.In addition, several other types of drugs, such as prostaglandins, diuretics, Na+,K+-ATPase inhibitors, and adenyl cyclase stimulators are just now beginning to be studied.

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“…32 Oral administration has been evaluated. However, there is a poor and variable absorption with this route, 33 at least for the cannabinoid formulations that have been investigated so far.…”

Section: Cannabinoids and Glaucomamentioning

confidence: 99%