Topically applied growth factors change skin cytoplasmic creatine kinase activity and distribution and produce abnormal keratinocyte differentiation in murine skin

Zemtsov, Alexander; Montalvo-Lugo, Victor

doi:10.1111/j.1600-0846.2008.00287.x

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…Because some malignant cells have receptors for certain GFs, and some GFs may increase cellular proliferation, there has been concern as to whether GFs might have the potential for tumorigenesis or promotion of cellular atypia. 55,56 Others postulate that exogenous GFs have a normalizing effect on the growth and differentiation of target cells. Studies of the effects of individual GFs on animal skin and on human tumor cells have shown conflicting results.…”

Section: Adverse Effects and Safety Considerationsmentioning

confidence: 99%

“…EGF and TGF-α both induced a transition from the CPK MM to CPK BB isoenzyme. 56 The significance of these findings is that the phosphocreatine/CPK system is believed to play an important role in the normal physiology of skin and in pathophysiological conditions such as psoriasis and carcinogenesis. Histopathological evaluation showed abnormal differentiation and distribution of keratinocytes.…”

Section: Adverse Effects and Safety Considerationsmentioning

confidence: 99%

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The Potential of Topical and Injectable Growth Factors and Cytokines for Skin Rejuvenation

2014

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). Keywords► growth factors ► cosmeceuticals ► platelet-rich plasma ► skin aging ► skin rejuvenation ► cytokines ► platelet-rich fibrin matrix ► transforming growth factor-β ► platelet-derived growth factor ► vascular endothelial growth factor AbstractGrowth factors and cytokines (referred to collectively hereafter as GFs) control cell growth, proliferation, and differentiation via a network of inter and intracellular signaling pathways. There are striking parallels between the pathways involved in skin wound healing and those implicated in photoaging of the skin. In recent years, topical and injectable GFs have emerged as an intriguing therapeutic modality that can be harnessed for aesthetic and medical purposes. This article provides a review of available evidence for the role in skin regeneration of topical GFs, and of injectable GFs contained in autologous platelet-rich plasma (PRP). It presents data from recent studies of GFs, offers a discussion of their potential to serve as antiaging actives, and includes safety considerations. As studies of injectable GFs typically assume preexisting familiarity with PRP protocols and the theory behind them, explanatory notes are provided. An assessment is provided of the evidence gaps that exist currently between experimental observations regarding GFs and their proven clinical benefits. Data of evidence levels II and III support the use for skin rejuvenation of topical GFs derived from sources including secretions or lysate of human dermal fibroblasts, and secretions of the snail Cryptomphalus aspersa. GFs with associated stem cell proteins, secreted by human dermal fibroblasts under hypoxic stress, can accelerate skin healing after laser resurfacing. In vitro and animal studies, small case series of PRP-treated patients and one prospective clinical study of its variant, platelet-rich fibrin matrix (PRFM), suggest the value of injectable GFs for skin rejuvenation. However, data of higher power are required to expand this proof of concept into an evidence-based paradigm. The clinical applications of topical and injectable GFs are promising, and remain to be fully defined.With continued study, data of higher evidence level can be accrued and formulations can be developed that offer optimal clinical efficacy, safety, tolerability, and stability. Better understanding of the mechanism of action of GFs can potentially advance our general understanding of dermal signaling pathways, and hence of hyaluronic acid and other alloplastic fillers; and allow the development of protocols for synergistic combination of GFs with other skin rejuvenation modalities. 157This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.In recent years, topical and injectable growth factors and cytokines have emerged as intriguing therapeutic modalities, with burgeoning interest in their potential to serve as actives for skin rejuvenation. Growth factors and cytokines (hereafter referred to collectively as GFs) may be applied topically in cosmeceutical fo...

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Section: Adverse Effects and Safety Considerationsmentioning

confidence: 99%

Section: Adverse Effects and Safety Considerationsmentioning

confidence: 99%

The Potential of Topical and Injectable Growth Factors and Cytokines for Skin Rejuvenation

2014

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Growth Factors in Cosmeceuticals

Fabi

Sundaram²

2013

Cosmeceuticals and Cosmetic Practice

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Facial intramuscular lipoma occurrence following topical cosmetic injection with a mixture of basic fibroblast growth factor: A report of two cases

Liao

Zhang

et al. 2017

Journal of Cosmetic and Laser Therapy

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Growth factors and cytokines control cell growth, proliferation and differentiation via a network of inter- and intracellular signalling pathways, and are involved in skin self-renewing and wound healing. In recent years, topical and injectable growth factors and cytokines have emerged as an intriguing therapeutic modality that can be harnessed for aesthetic purposes. However, very little data are available on their long-term safety and tolerability. In this report, we describe two cases of patients, who developed intramuscular lipoma of the chin following topical injection with a mixture of basic fibroblast growth factor as the main ingredients for chin augmentation. Biopsies in the two cases were performed at our department, and revealed intramuscular lipoma. Our report indicates that the topical injection of growth factors can lead to tumorigenesis, so health care providers need to be aware of its potential consequences.

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Topically applied growth factors change skin cytoplasmic creatine kinase activity and distribution and produce abnormal keratinocyte differentiation in murine skin

Abstract: The skin PCR/CPK system is affected by growth factors. Furthermore, this system appears to play an important role, both in the normal physiology of skin and pathophysiological conditions such as psoriasis and carcinogenesis.

Cited by 4 publications

References 16 publications

The Potential of Topical and Injectable Growth Factors and Cytokines for Skin Rejuvenation

The Potential of Topical and Injectable Growth Factors and Cytokines for Skin Rejuvenation

Growth Factors in Cosmeceuticals

Facial intramuscular lipoma occurrence following topical cosmetic injection with a mixture of basic fibroblast growth factor: A report of two cases

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