Topikal Prostaglandin Analogları ve Hiperpigmentasyon

Abstract

Topical prostaglandin analogues are among commonly used glaucoma medications. These are considerably safe drugs, however they have some local adverse effects such as conjunctival hyperemia, iris hyperpigmentation, elongation and darkening of eyelashes, and periocular skin hyperpigmentation. The aim of the present article is to review available literature data on topical prostaglandin analogue-induced hyperpigmentation of iris, eyelash and periocular skin and to evaluate the clinical features, possible etiopathogenetic mechanisms, and clinical outcomes.