Topiramate diminishes fear memory consolidation and extinguishes conditioned fear in rats

Prado-Lima, Pedro Antônio Schmidt do; Perrenoud, Myriam Fortes; Kristensen, Christian Haag; Cammarota, Martı́n; Izquierdo, Iván

doi:10.1503/jpn.100115

Cited by 6 publications

(3 citation statements)

References 28 publications

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“…In post-traumatic stress disorder and borderline personality disorder, TPM was proposed to facilitate traumatic memory extinction. It is interesting to note that traumatic memory extinction is not thought to be due to the memory-impairing properties of TPM, since memory retrieval is necessary fear memory extinction [Do Prado-Lima et al 2011].…”

Section: Effects Of Tpm On Cognition In Patients With Psychiatric Disordersmentioning

confidence: 99%

Topiramate: Effects on cognition in patients with epilepsy, migraine headache and obesity

Sommer

Mitchell

Wroolie

2013

Ther Adv Neurol Disord

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This paper reviews the clinical implications of topiramate (TPM)-induced cognitive deficits in patients with epilepsy, migraine headache, obesity, and in normal populations, followed by reviews of the literature describing the reversal of such deficits upon medication discontinuation. It also discusses animal investigations of TPM's role of neuroprotection in brain injury. TPM's most intolerable adverse effects (AEs) are on verbal fluency and reaction time, resulting in high discontinuation rates in patients taking it for epilepsy and migraine headache. However, because TPM is so effective in the treatment of epilepsy and migraine headache, its use is expected to continue. There appears to be greater tolerance of TPM's cognitive AEs when it is used in the treatment of obesity, perhaps because of the lower doses required. Research attempting to predict the populations most vulnerable to the cognitive effects caused by TPM is ongoing. Studies suggest that one such population may include patients with a past psychiatric history. Slow titration and administration of the lowest possible doses may decrease risk of cognitive deficits.

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Section: Effects Of Tpm On Cognition In Patients With Psychiatric Disordersmentioning

confidence: 99%

Topiramate: Effects on cognition in patients with epilepsy, migraine headache and obesity

Sommer

Mitchell

Wroolie

2013

Ther Adv Neurol Disord

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“…Additionally, many studies have focused on the process of fear extinction following contextual or cued fear conditioning in the rodents as a predominant symptom of PTSD [105,120]. Most of the drugs with the reported clinical efficacy have demonstrated anti-PTSD characteristics in the rodent models (Table 1) [95,96,97,98,99,100,101,102,103,104,106,107,108,109], suggesting that the efficacy of drugs was initially evaluated using the above animal models. However, whether the chronic stress-induced models reflect PTSD pathology is still questionable, due to the lack of reproducibility in different studies.…”

Section: Animal Models Of Ptsdmentioning

confidence: 99%

Clinical Therapeutic Strategy and Neuronal Mechanism Underlying Post-Traumatic Stress Disorder (PTSD)

Yabuki

Fukunaga

2019

IJMS

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Post-traumatic stress disorder (PTSD) is characterized by an exaggerated response to contextual memory and impaired fear extinction, with or without mild cognitive impairment, learning deficits, and nightmares. PTSD is often developed by traumatic events, such as war, terrorist attack, natural calamities, etc. Clinical and animal studies suggest that aberrant susceptibility of emotion- and fear-related neurocircuits, including the amygdala, prefrontal cortex (PFC), and hippocampus may contribute to the development and retention of PTSD symptoms. Psychological and pharmacological therapy, such as cognitive behavioral therapy (CBT), and treatment with anti-depressive agents and/or antipsychotics significantly attenuate PTSD symptoms. However, more effective therapeutics are required for improvement of quality of life in PTSD patients. Previous studies have reported that ω3 long-chain polyunsaturated fatty acid (LCPUFA) supplements can suppress the development of PTSD symptoms. Fatty acid binding proteins (FABPs) are essential for LCPUFA intracellular trafficking. In this review, we have introduced Fabp3 null mice as an animal model of PTSD with impaired fear extinction. Moreover, we have addressed the neuronal circuits and novel therapeutic strategies for PTSD symptoms.

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“…In step-down inhibitory avoidance task, one critical point was the application of various electric current intensities, ranging from 0.3mA to 3mA[ 17 – 20 ].The stimulus intensities reflect in the latency of step-down in the test trial (24 h after training). For male Wistar rats (age, 2–3 months, weight, 220–260 g), researchers showed the latency for step-down in the test of ±40–50 seconds with 2 seconds of stimulus in intensities of 0.3mA [ 7 ],0.4mA[ 15 , 21 ] and 0.5mA[ 22 – 26 ];step-down latencies of 180s in test applied 0.8mA (2s) in training[ 22 , 27 ] and 600 s for 1mA (2s)[ 28 ].…”

Section: Introductionmentioning

confidence: 99%

A New Device for Step-Down Inhibitory Avoidance Task—Effects of Low and High Frequency in a Novel Device for Passive Inhibitory Avoidance Task That Avoids Bioimpedance Variations

et al. 2015

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BackgroundStep-down inhibitory avoidance task has been widely used to evaluate aversive memory, but crucial parameters inherent to traditional devices that may influence the behavior analysis (as stimulus frequency, animal’s bioimpedance) are frequently neglected.New MethodWe developed a new device for step-down inhibitory avoidance task by modifying the shape and distribution of the stainless steel bars in the box floor where the stimuli are applied. The bars are 2mm wide, with rectangular shape, arranged in pairs at intervals of 1cm from the next pairs. Each pair makes an electrical dipole where the polarity inverts after each pulse. This device also presents a component that acquires and records the exact current received by the animal foot and precisely controls the frequency of stimulus applied during the entire experiment.ResultDifferent from conventional devices, this new apparatus increases the contact surface with bars and animal´s paws, allowing the electric current pass through the animal´s paws only, drastically reducing the influence of animal’s bioimpedance. The analysis of recorded data showed that the current received by the animal was practically the same as applied, independent of the animal´s body composition. Importantly, the aversive memory was observed at specific stimuli intensity and frequency (0.35 or 0.5 mA at 62 and 125Hz but not at 0.20 mA or 20 Hz). Moreover, with this device it was possible to observe the well-known step-down inhibitory avoidance task memory impairment induced by guanosine.ConclusionThis new device offers a substantial improvement for behavioral analysis in step-down inhibitory avoidance task and allows us to precisely compare data from different animals with distinct body composition.

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Topiramate diminishes fear memory consolidation and extinguishes conditioned fear in rats

Cited by 6 publications

References 28 publications

Topiramate: Effects on cognition in patients with epilepsy, migraine headache and obesity

Topiramate: Effects on cognition in patients with epilepsy, migraine headache and obesity

Clinical Therapeutic Strategy and Neuronal Mechanism Underlying Post-Traumatic Stress Disorder (PTSD)

A New Device for Step-Down Inhibitory Avoidance Task—Effects of Low and High Frequency in a Novel Device for Passive Inhibitory Avoidance Task That Avoids Bioimpedance Variations

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