Topiramate in multidrug withdrawal — comparison with clonidine

Krenz, Sonia; Zimmermann, Grégoire; Pin, Martin; Kolly, Stéphane; Besson, J; Zullino, D.

doi:10.1016/s0924-9338(02)80911-7

European Psychiatry

2002

DOI: 10.1016/s0924-9338(02)80911-7

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Topiramate in multidrug withdrawal — comparison with clonidine

Sonia Krenz

Grégoire Zimmermann

Martin Pin

et al.

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“…In vitro, topiramate has no effect on NMDA mediated excitatory amino acid receptors. Whereas recently we have reported on its use in opiate detoxification Krenz et al, 2002), we report here the case of a patient treated successfully with topiramate for his benzodiazepine withdrawal. CASE REPORT Mr A., 41 years old, had been using cannabis since the age of 13, opiates and cocaine since the age of 20 and had been abusing benzodiazepines for more than 10 years.…”

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confidence: 98%

Topiramate in benzodiazepine withdrawal

Cheseaux¹,

Monnat²,

Zullino³

2003

Human Psychopharmacology

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There is an increasing interest in anticonvulsants for the treatment of benzodiazepine withdrawal symptoms. The new anticonvulsant compound topiramate seems to be an especially promising drug for this indication. It acts, among others, as an AMPA antagonist, which may be responsible in part for its anticonvulsant efficacy, but may also modulate the withdrawal-induced activation of noradrenergic neurons in the locus coeruleus, which are related to some behavioural effects of benzodiazepine withdrawal. A case is presented of a rapid benzodiazepine-withdrawal treated successfully with topiramate.

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mentioning

confidence: 98%

Topiramate in benzodiazepine withdrawal

Cheseaux¹,

Monnat²,

Zullino³

2003

Human Psychopharmacology

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The efficiency of a carbamazepine–mianserin combination scheme in opiate detoxification

Zullino

Krenz

Favrat

et al. 2004

Human Psychopharmacology

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A recent comparative randomized double-blind study has suggested the utility of a carbamazepine/mianserin combination as a treatment for opiate withdrawal. The aim of the present study was to explore the feasibility and efficiency of this combination under naturalistic conditions. Five hundred and fifty mostly polysubstance abusing patients treated with a standardized scheme combining carbamazepine and mianserin were assessed with regard to deviations to the protocol, used co-medications and retention in treatment. Three hundred and sixty three patients (66.0%) received the carbamazepine/mianserin combination as specified by the standardized protocol. In 350 patients (63.7%) the whole 10 days was completed. The most frequently used p.r.n. medications were for anxiety (47.5%) and insomnia (54.5%). The treatment of opiate withdrawal with a carbamazepine/mianserin combination scheme in an inpatient setting seems to be feasible and applicable with few adaptations to most patients, and may represent an interesting treatment option for multidrug users.

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Topiramate in multidrug withdrawal — comparison with clonidine

Cited by 2 publications

References 0 publications

Topiramate in benzodiazepine withdrawal

Topiramate in benzodiazepine withdrawal

The efficiency of a carbamazepine–mianserin combination scheme in opiate detoxification

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