Topiramate in the Treatment of Binge Eating Disorder Associated With Obesity: A Randomized, Placebo-Controlled Trial

McElroy, Susan L.; Arnold, Lesley M.; Shapira, Nathan A.; Keck, Paul E.; Rosenthal, Norman; Karim, Mohammad Rezaul; Kamin, Marc; Hudson, James I.

doi:10.1176/appi.ajp.160.2.255

Cited by 437 publications

(264 citation statements)

References 24 publications

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“…[16][17][18] In addition, both eating disorders and BDD are characterized by obsessional preoccupations and repetitive behaviors (e.g., mirror checking, body measuring). 13,15 Indeed, modifications of the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) are used to assess the severity of both BDD and eating disorders (anorexia nervosa [AN] and binge eating disorder [BED]), [19][20][21] and both disorders have been characterized as obsessivecompulsive spectrum disorders. [22][23][24] In addition, clinical observations suggest that BDD and eating disorders share overvalued and often firmly sustained appearance-related beliefs, as well as a quest to improve one's appearance.…”

Section: Discussionmentioning

confidence: 99%

Comorbidity of body dysmorphic disorder and eating disorders: Severity of psychopathology and body image disturbance

Ruffolo

Phillips

Menard

et al. 2006

Int. J. Eat. Disord.

196

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Section: Discussionmentioning

confidence: 99%

Comorbidity of body dysmorphic disorder and eating disorders: Severity of psychopathology and body image disturbance

Ruffolo

Phillips

Menard

et al. 2006

Int. J. Eat. Disord.

196

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“…Os autores concluíram pela ausência de evidência de eficácia em longo prazo no uso de antidepressivos para o controle do TCAP 54,55 . O topiramato mostra-se eficaz na redução de episódios de compulsão alimentar em diversos estudos [56][57][58] . Zilberstein et al documentaram a eficácia de topiramato em pacientes apresentando compulsão alimentar após colocação de banda gástrica (LAGB) 59 .…”

Section: Compulsão Alimentar E Cirurgia Bariátricaunclassified

Aspectos do acompanhamento psiquiátrico de pacientes obesos sob tratamento bariátrico: revisão

Gordon

Kaio²,

Sallet³

2011

Rev. psiquiatr. clín.

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ResumoContexto: Nas últimas décadas, diversos estudos longitudinais têm demonstrado a eficácia da cirurgia bariátrica no controle de peso em longo prazo e na redução da mortalidade resultante de complicações clínicas associadas à obesidade. Contudo, os estudos também revelam aumento significativo da mortalidade devida a suicídio e comportamento impulsivo, por razões largamente desconhecidas, o que demonstra a escassez de informações relativas ao manejo clínico de pacientes bariátricos. O presente estudo tem como objetivo sintetizar o estado atual de conhecimentos referentes ao acompanhamento psiquiátrico de pacientes bariátricos. Método: Revisão seletiva da literatura envolvendo artigos indexados no Medline e PubMed até junho de 2010, utilizando-se os termos: "bariatric surgery", "psychiatry", "binge eating", "follow-up" e "outcome". Resultados: Há relativo consenso na literatura de que não haja contraindicação psiquiátrica absoluta para a cirurgia bariátrica, embora a avaliação pré-operatória seja de extrema importância para o diagnóstico e tratamento de eventuais transtornos psiquiátricos, objetivando assegurar aderência ao tratamento multidisciplinar, melhor qualidade de vida e, possivelmente, melhor prognóstico pós-cirúrgico. Entre os transtornos mais prevalentes nessa população, encontra-se o transtorno da compulsão alimentar periódica (TCAP), que está relacionado com menor perda ponderal e pior qualidade de vida, especialmente quando presente no pós-operatório. No acompanhamento pós-operatório, também se deve atentar para o surgimento de sintomas impulsivos, incluindo abuso de álcool e outras substâncias. Conclusão: Diversos estudos indicam elevada prevalência de transtornos mentais e alterações psicopatológicas na população de pacientes bariátricos. Embora a maioria dos pacientes apresente adequado controle ponderal e melhora na qualidade de vida em médio e longo prazo, alguns pacientes desenvolvem alterações relativas ao comportamento alimentar, abuso de álcool e outras substâncias e complicações associadas a comportamento impulsivo, o que remete a hipóteses etiológicas que vão desde modelos neuroquímicos até teorias psicossociais. Por todas essas razões, é de fundamental importância que os profissionais de saúde mental integrem as equipes que avaliam e acompanham os pacientes bariátricos. Gordon PC, et al. / Rev Psiq Clín. 2011;38(4):148-54Palavras-chave: Obesidade, cirurgia bariátrica, psiquiatria, transtorno da compulsão alimentar periódica. AbstractBackground: In recent decades, several longitudinal studies show the efficacy of bariatric surgery on long-term weight control and reductions in mortality due to clinical complications associated with obesity. However, studies also show significantly increased mortality due to suicide and impulsive behavior, for reasons largely unknown, which demonstrates the paucity of information concerning the clinical management of bariatric patients. This study aims to synthesize the current state of knowledge regarding the psychiatric care of bariatric patients. Meth...

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“…21 It is also efficacious in the treatment of binge-eating disorder associated with obesity. 22 Clinical trials of TPM in obese patients demonstrated that TPM was significantly more efficacious than placebo. 5,6,22 Current investigation of TPM as a potential new therapy for obesity is underway.…”

Section: Discussionmentioning

confidence: 99%

“…22 Clinical trials of TPM in obese patients demonstrated that TPM was significantly more efficacious than placebo. 5,6,22 Current investigation of TPM as a potential new therapy for obesity is underway. 23 Glucose uptake lies at the center when dealing with energy expenditure and glucose homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Topiramate stimulates glucose transport through AMP-activated protein kinase-mediated pathway in L6 skeletal muscle cells

Yim

Jung

et al. 2006

Pharmacogenomics J

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The use of topiramate (TPM) in the treatment of binge-eating disorder, bulimia nervosa, and antipsychotic-induced weight gain has recently increased, however, the exact molecular basis for its effects on body weight reduction and improved glucose homeostasis, is yet to be elucidated. Here we investigated the effect and signaling pathway of TPM on glucose uptake in L6 rat skeletal muscle cells, which account for 470% of glucose disposal in the body. Intriguingly, we found that TPM (10 mM) stimulated the rate of glucose uptake up to twofold increase. And TPM-stimulated glucose transport was inhibited with the overexpression of dominant-negative form of AMP-activated protein kinase (AMPK), an important mediator in glucose transport, implicating that AMPK-mediated pathway is involved. The TPMstimulated glucose transport was blocked by SB203580, a specific inhibitor of AMPK downstream mediator, p38 mitogen-activated protein kinase (MAPK) protein. LY294002, an inhibitor of phosphatidylinositol (PI) 3-kinase, which is another crucial mediator in independent glucose transport pathway, did not inhibit TPM-stimulated glucose transport. We also found that TPM increased the phosphorylation level of AMPK and p38 MAPK, whereas no effect on the activity of PI 3-kinase of TPM, when assessed by PI 3-kinase assay, was observed. These results together suggest that TPM stimulates glucose transport, not via PI 3-kinase mediated, but via AMPK-mediated pathway in skeletal muscle cells, thereby contributing to the body weight regulation and glucose homeostasis.

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Topiramate in the Treatment of Binge Eating Disorder Associated With Obesity: A Randomized, Placebo-Controlled Trial

Abstract: Topiramate was efficacious and relatively well tolerated in the short-term treatment of binge eating disorder associated with obesity.

Cited by 437 publications

References 24 publications

Comorbidity of body dysmorphic disorder and eating disorders: Severity of psychopathology and body image disturbance

Comorbidity of body dysmorphic disorder and eating disorders: Severity of psychopathology and body image disturbance

Aspectos do acompanhamento psiquiátrico de pacientes obesos sob tratamento bariátrico: revisão

Topiramate stimulates glucose transport through AMP-activated protein kinase-mediated pathway in L6 skeletal muscle cells

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