Topiramato y embarazo. Recién nacido con anomalías óseas

Cerén, Clara Vila; Guasch, X. Demestre; Torrent, F. Raspall; Saco, MJ Elizari; Castellví, P. Sala; Martínez-Nadal, S.

doi:10.1157/13079819

Cited by 11 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…O topiramato atravessa livremente a barreira hematoencefálica e, portanto, os níveis séricos maternos e fetais são equiparáveis no momento do parto. 48 Perucca e colaboradores 49 não relataram nenhum caso de malformação em dez gestantes tratadas em monoterapia com topiramato. O topiramato afeta diferentes alvos moleculares, inclusive os canais voltagem-dependentes de sódio e cálcio, receptores GABA, AMPA e cainato, todos modulados pela proteína quinase.…”

Section: Topiramatounclassified

Tratamento de gestantes com epilepsia: papel dos medicamentos antiepilépticos clássicos e novos

Hirama

Dias

Matsudo

et al. 2008

J. epilepsy clin. neurophysiol.

View full text Add to dashboard Cite

As epilepsias constituem a doença neurológica crônica grave mais comum e têm implicações terapêuticas relacionadas ao sexo. As informações sobre os riscos do uso das drogas antiepilépticas clássicas e novas durante a gestação são muito importantes tanto para a saúde da mulher quanto para a do feto. OBJETIVO: Realizar uma revisão da literatura referente aos aspectos terapêuticos das gestantes com epilepsia. MÉTODO: Revisão da literatura com o uso das palavras chave: epilepsia/crises/convulsões e gestação, drogas antiepilépticas, farmacocinética, teratogênese, malformações e uso de folato/ácido fólico. DISCUSSÃO E CONCLUSÃO: As metodologias utilizadas são muito variáveis além de ocorrerem complicações decorrentes do uso das novas drogas. A contribuição do uso das DAE novas e tradicionais, sua farmacocinética e a ocorrência de epilepsia/crises na gestação podem prejudicar a evolução da gravidez e não têm sido claramente delineadas. Os autores enfatizam a necessidade de estudos para avaliar o impacto da epilepsia e seu tratamento na vida reprodutiva, a fim de otimizar seu tratamento, além da necessidade de estudos farmacocinéticos durante a gestação para obtenção de melhores resultados terapêuticos e também para a diminuição dos efeitos nocivos das drogas sobre a mãe e o feto.

show abstract

Section: Topiramatounclassified

Tratamento de gestantes com epilepsia: papel dos medicamentos antiepilépticos clássicos e novos

Hirama

Dias

Matsudo

et al. 2008

J. epilepsy clin. neurophysiol.

View full text Add to dashboard Cite

show abstract

“…The born child was noted to have generalized hirsutism, a short nose and generalized blunting of the nails, with fifth nail hypoplasia [3]. Children, whose mother received topiramate throughout pregnancy, were born with bone abnormalities in their thumbs and toes [4].…”

Section: Introductionmentioning

confidence: 99%

Histopathologic Effect of Prenatal Topiramate Exposure on Rat Cerebral Cortex and Hippocampus

Hashish¹

2014

J Interdiscipl Histopathol

View full text Add to dashboard Cite

Objective: Topiramate is a recent antiepileptic agent approved for treatment of seizure in adults, children and during pregnancy. No much available reports concerning topiramate teratogenic potential in humans. This could be explained by limited number of pregnancies exposed. Very few reports are available on animal experimentation with controversial results. This work aimed to clarify the histopathologic effects of prenatal topiramate exposure on the cerebral cortex and the hippocampus of newborn rats. Material and methods: 12 female pregnant rats were divided into control and treated groups, 6 rats in each group. The treated group was given topiramate dissolved in tap water, from day 0 of pregnancy till the delivery, through oral route in dose of 200mg/kg. The control group received tap water at the same time. In the end of the treatment, the cerebral cortex and the hippocampus were stained with hematoxylin and eosin (H&E) and immnunohistochemically for glial fibrillary acidic protein (GFAP). Results: The control rat cerebral cortex showed that granule cells were small cell with dense cytoplasm, pyramidal cells appeared with triangular cell body, light cytoplasm and small nucleus. Strong GFAP positive immunostaining was detected in the astrocytes in both granule cell and pyramidal cell layers. The pyramidal cells in Cornu Ammonis showed characteristic palisade arrangement, with lightly stained cytoplasm and central nucleus. Granule cells of the dentate gyrus were rounded, packed, dense. Strong GFAP positive immunostaining was detected in the astrocytes in both pyramidal cell and granule cell layers. In treated rats, granule and pyramidal cells in the cerebral cortex and hippocampus were disorganized with signs of degeneration. Faint GFAP positive immunostaining was detected in the astrocytes in granule and pyramidal cell layers. Conclusion: Long-term daily use of topiramate during pregnancy can lead to noticeable pathological neurotoxic effect in the cerebral cortex and hippocampus which may be implicated in cognitive affection. Neurological effect of topiramate necessitates further investigations.

show abstract

Preventive Treatment Options for the Pregnant Headache Patient

Marcus

Bain

2008

Effective Migraine Treatment in Pregnant and Lactating Women: A Practical Guide

View full text Add to dashboard Cite

Topiramato y embarazo. Recién nacido con anomalías óseas

Cited by 11 publications

References 17 publications

Tratamento de gestantes com epilepsia: papel dos medicamentos antiepilépticos clássicos e novos

Tratamento de gestantes com epilepsia: papel dos medicamentos antiepilépticos clássicos e novos

Histopathologic Effect of Prenatal Topiramate Exposure on Rat Cerebral Cortex and Hippocampus

Preventive Treatment Options for the Pregnant Headache Patient

Contact Info

Product

Resources

About