Topische Behandlung von Pigmentstörungen mit kosmetischen und pharmazeutischen Wirkstoffen

Design, synthesis, and inhibitory activity of hydroquinone ester derivatives against mushroom tyrosinase

“…Nevertheless, it was discovered that hydroquinone could be skin-irritating, and prolonged use could lead to a severe condition known as exogenous ochronosis. 5 Consequently, the inclusion of hydroquinone in skincare products has been prohibited in China and Europe, though it remains permitted for pharmaceutical use.…”

Tirbanibulin and solar lentigo clearance: an aesthetically pleasing side effect?

“…2,3 While the first is at risk of progression to squamous cell carcinoma and treatment is mandatory, 2 solar lentigos are defined as completely benign lesions that are treated only for cosmetic purposes. 4 Tirbanibulin is the latest topical drug in the armamentarium against actinic keratoses. 5 It targets tubulin polymerization and induces complete G2/M cell cycle arrest, leading to cellular apoptosis.…”

“…5 Topical agents for the treatment of hyperpigmentation disorders, such as hydroquinone and triple combination cream with tretinoin, fluocinolone acetonide, and hydroquinone, do exist, even though mixed outcomes are reported in the literature when it comes to their efficacy. 4 Given that ultraviolet radiation is acknowledged as a significant risk factor in the development of actinic keratosis through the induction of mutations in epidermal keratinocytes, 6 it is fairly common to observe the correlation between premalignant skin lesions and sun-damaged skin characterized by an abundance of solar lentigos. It is not feasible to suggest tirbanibulin as a cosmetic therapy for solar lentigos, but in the case of a patient with multiple actinic keratoses associated with benign melanocytic lentigos, particularly on the face, it may be an intriguing therapeutic choice because of the simple dosage regimen and the aesthetic advantages.…”