Topische EGF-Applikation bei therapierefraktärer Erosio corneae unter Cetuximab-Behandlung

Förster, Claudia; Cursiefen, Claus; Kruse, Friedrich E.

doi:10.1007/s00347-007-1527-8

Cited by 9 publications

(3 citation statements)

References 6 publications

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“…Among the numerous known growth factors, EGF, NGF, and IGF-1 have been tested clinically for enhancing healing of corneal epithelial defects. 4,17,18) Growth factors such as KGF-2 play a critical role in the epithelial development 19,20) and KGF-2, specifically, exerts its biological activities in a paracrine manner on FGFR2-IIIb, a …”

Section: Discussionmentioning

confidence: 99%

“…Cetuximab (an EGFR antibody) can cause persistent epithelial defects, and patients with an impairment of corneal wound healing under cetuximab treatment can benefit from the topical application of human EGF. 4) EGF and TGF-a are synthesized by the lacrimal gland and are present in physiologically significant concentrations in tears. 5) Cornea epithelial cells also synthesize mRNA for EGF and TGF-a protein.…”

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confidence: 99%

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Effects of Keratinocyte Growth Factor-2 on Corneal Epithelial Wound Healing in a Rabbit Model of Carbon Dioxide Laser Injury

Wang

Zhou²,

et al. 2010

Biological & Pharmaceutical Bulletin

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Keratinocyte growth factor-2 (KGF-2), also called fibroblast growth factor-10 (FGF-10), is a member of the fibroblast growth factor family. It plays a critical role in epithelial development and exerts its biological activities in a paracrine manner on the receptor FGFR2-IIIb. This study examined the function of topically applied KGF-2 in vivo on wound healing using a CO 2 laser, corneal epithelial wounded, rabbit model. Topically applied 25 m mg/ml KGF-2 accelerated corneal epithelial wound healing, in contrast to the control, and reduced inflammation, stromal edema, and fibrosis. In addition, this factor also exhibited significant inhibition of corneal neovascularization. KGF-2 appears to be another important growth factor in the regulation of corneal epithelial wound healing.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Effects of Keratinocyte Growth Factor-2 on Corneal Epithelial Wound Healing in a Rabbit Model of Carbon Dioxide Laser Injury

Wang

Zhou²,

et al. 2010

Biological & Pharmaceutical Bulletin

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“…However, expression of bFGF was not significantly different under the two culture conditions. EGF exists in various body fluids, for example in tears, and can stimulate the proliferation of corneal epithelial cells both in vitro and in vivo [31,32]. It is one of the most important mitogens of corneal epithelial cells [33,34].…”

Section: Discussionmentioning

confidence: 99%

Effects of Bone Marrow Mesenchymal Stem Cells on Cell Proliferation and Growth Factor Expression of Limbal Epithelial Cells in vitro

Zhang

et al. 2012

Ophthalmic Res

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Mesenchymal stem cells (MSCs) can play an active role in the reconstruction of the ocular surface; however, the mechanisms by which the implanted MSCs exert their effects remain elusive. In the present study, we investigated the influences of MSCs on cell proliferation and growth factor expression of corneal limbal epithelial cells (LECs) in vitro. Rat LECs were either cocultured with rat MSCs or cultured in rat MSC-conditioned medium. The harvested LECs were subjected to light microscopy, MTT assay, bromodeoxyuridine (BrdU) staining, flow cytometry and real-time quantitative RT-PCR analysis, respectively. Light microscopy showed that coculturing of LECs with MSCs significantly increased the proliferation of LECs. The MTT assay showed that MSC-conditioned medium significantly increased the cell viability of LECs compared to those incubated with plain medium. BrdU immunostaining and flow-cytometric analysis of the cell cycle showed that the cell proliferation rate of LECs cocultured with MSCs was significantly higher than that of LECs cultured alone. Real-time quantitative RT-PCR analysis showed that expression of epidermal growth factor in LECs cocultured with MSCs was significantly higher than that in LECs cultured alone. However, expression of basic fibroblast growth factor showed no difference under the two culture conditions. These results indicate that MSCs promote the survival and proliferation of LECs, and these effects may be mediated in a paracrine manner.

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Ocular Adverse Events of Systemic Inhibitors of the Epidermal Growth Factor Receptor: Report of 5 Cases

et al. 2012

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Topische EGF-Applikation bei therapierefraktärer Erosio corneae unter Cetuximab-Behandlung

Abstract: Cetuximab (Erbitux) can cause persisting epithelial defects. Patients with an impairment of corneal wound healing under cetuximab treatment can benefit from the topical application of human EGF. Consequently, surgical measures or complications such as infections can be avoided.

Cited by 9 publications

References 6 publications

Effects of Keratinocyte Growth Factor-2 on Corneal Epithelial Wound Healing in a Rabbit Model of Carbon Dioxide Laser Injury

Effects of Keratinocyte Growth Factor-2 on Corneal Epithelial Wound Healing in a Rabbit Model of Carbon Dioxide Laser Injury

Effects of Bone Marrow Mesenchymal Stem Cells on Cell Proliferation and Growth Factor Expression of Limbal Epithelial Cells in vitro

Ocular Adverse Events of Systemic Inhibitors of the Epidermal Growth Factor Receptor: Report of 5 Cases

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