Topisches Mitomycin C zur Rezidivprophylaxe von Haze nach erneuter Excimer-Laser-photorefraktiver Keratektomie (PRK) - Klinische Pilotstudie an 5 Patienten1

Abstract

Topical applied mitomycin C seems to be a promising therapy to prevent recurrent haze after a second PRK procedure. As mitomycin C can be associated with a variety of serious complications, it should only be used in patients with high risk of haze.

Apoptosis in Keratocytes Caused by Mitomycin C

“…The 9-month follow-up revealed that the surgically treated corneas remained clear. 18 Majmudar et al 31 demonstrated that topical application of mitomycin C (0.02%) successfully prevented the recurrence of epithelial fibrosis after debridement. Eight corneas undergoing mitomycin C treatment after debridement remained clear, with no recurrence or adverse reaction throughout the follow-up periods (6 -25 months).…”

“…16 Mitomycin C reduces keratocytes in the anterior stroma after corneal refractive surgery, leading to a decrease in activated fibroblasts, production of extracellular matrix, and formation corneal haze. [17][18][19][20] Mitomycin C, an alkylating antibiotic agent derived from Streptomyces caespitosus, blocks DNA and RNA replication and protein synthesis. The compound is metabolized by liver enzymes to form an alkylating agent that nonspecifically crosslinks with DNA in a cell-cycle-dependent manner.…”

Ceramide-Induced Apoptosis in Rabbit Corneal Fibroblasts

“…Mitomycin C and steroids have been found to prevent corneal opacity, and the former has been effective in several clinical trials. [29][30][31][32] In this study, we tested ceramides to determine their effect on rabbit corneal fibroblasts.…”

Transepithelial phototherapeutic keratectomy/photorefractive keratectomy with adjunctive mitomycin-C for complicated LASIK flaps

“…[15][16][17][18][19][20] Based on its success in the treatment of symptomatic haze, MMC has been evaluated as a prophylactic agent for the prevention of haze following high-risk PRK. 21,22 We hypothesized that surface ablation over a LASIK flap with adjunctive MMC would result in excellent refractive outcomes and minimize the risk for postoperative corneal haze. We report 10 eyes of 10 patients with flap complications who had phototherapeutic keratectomy (PTK)/PRK followed by prophylactic use of MMC (PTK/PRK/MMC) with the intended refractive outcome of emmetropia.…”