Topographic mapping of sperm DNA fragmentation within the male genital tract

Cozzubbo, T.; Neri, Q.V.; Goldstein, Marc; Rosenwaks, Zev; Palermo, G.D.

doi:10.1016/j.fertnstert.2014.07.634

Cited by 5 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This theory was supported by topographic DFI mapping performed at discrete locations along the male reproductive tract (32). In this analysis, ejaculated sperm demonstrated the highest DFI and testicular sperm the lowest (32). Other studies have similarly shown higher DFI in ejaculated sperm compared with testicular sperm in men with oligozoospermia (38,39).…”

Section: Discussionsupporting

confidence: 66%

“…DNA damage has been postulated to occur during sperm transit through the male genital tract, resulting from oxidative insults to the spermatic DNA by reactive oxidative species (35)(36)(37). This theory was supported by topographic DFI mapping performed at discrete locations along the male reproductive tract (32). In this analysis, ejaculated sperm demonstrated the highest DFI and testicular sperm the lowest (32).…”

Section: Discussionmentioning

confidence: 76%

“…Attempts to specifically correlate ICSI outcomes with DFI have yielded inconsistent results. Two studies-one prospective and one retrospective-have shown reduced fertilization rates with increasing DFI levels in ICSI (16,32), whereas other studies show no differences (33,34).…”

Section: Discussionmentioning

confidence: 96%

“…The analyzed studies were all retrospective and limited in number. There may be other rationales to proceed with TESA in the setting of cryptozoospermia, including the unreliable presence of sperm in the ejaculate in preparation for an IVF cycle, an inadequate absolute number of sperm available in the ejaculate, or abnormal ejaculated sperm DFI (10,32). These latter rationales for surgery are not examined by our analysis.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Use of testicular versus ejaculated sperm for intracytoplasmic sperm injection among men with cryptozoospermia: a meta-analysis

Abhyankar

Kathrins

Niederberger

2016

Fertility and Sterility

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Use of testicular versus ejaculated sperm for intracytoplasmic sperm injection among men with cryptozoospermia: a meta-analysis

Abhyankar

Kathrins

Niederberger

2016

Fertility and Sterility

View full text Add to dashboard Cite

show abstract

“…Second, sperm suffer oxidative stress and nuclear DNA damage during transit through the male genital tract. [22–24] Sperm in men with advanced paternal age are more vulnerable to such damage. Increased DNA fragmentation indices have been associated with worse pregnancy outcomes.…”

Section: Discussionmentioning

confidence: 99%

Effect of paternal age on intracytoplasmic sperm injection outcomes in cryptozoospermic men

Xi²,

Zhang³

et al. 2019

Medicine

View full text Add to dashboard Cite

It is not clear whether age has any influence on the outcomes for sperm used for assisted reproductive technology in cryptozoospermic men. We evaluated intracytoplasmic sperm injection (ICSI) outcomes using ejaculated or testicular sperm in men with cryptozoospermia from different paternal age ranges. We conducted a retrospective observational study of 35 men with cryptozoospermia who underwent ICSI from 2010 to 2018. They were classified into 2 groups based on male age, namely < 35 years and ≥ 35 years. Each group was further divided into 2 subgroups according to the origin of sperm (ejaculated or testicular). In the <35 years group, the normal fertilization and high-quality embryo rates for ejaculated sperm were significantly higher than with testicular sperm (74.7% vs. 62.4%, P = .02; 50.5% vs. 36.6%, P = .03, respectively). However, in the ≥35 years group, the high-quality embryo and clinical pregnancy rates were significantly lower in the ejaculated sperm subgroup than in the testicular sperm subgroup (26.2% vs. 63%, P = .002; 12.5% vs. 71.4%, P = .04, respectively). This study indicates that ICSI should be performed as soon as possible for men with cryptozoospermia. When the paternal age ≥35 years, testicular sperm should be used for ICSI, as this offers better high-quality embryo and clinical pregnancy rates.

show abstract

Implications of Sperm Source on ICSI Outcome: Assessment of TESE and Other Surgical Sperm Retrieval Methods

Abhyankar

Ohlander

Kathrins

2018

Intracytoplasmic Sperm Injection

View full text Add to dashboard Cite

Topographic mapping of sperm DNA fragmentation within the male genital tract

Cited by 5 publications

References 0 publications

Use of testicular versus ejaculated sperm for intracytoplasmic sperm injection among men with cryptozoospermia: a meta-analysis

Use of testicular versus ejaculated sperm for intracytoplasmic sperm injection among men with cryptozoospermia: a meta-analysis

Effect of paternal age on intracytoplasmic sperm injection outcomes in cryptozoospermic men

Implications of Sperm Source on ICSI Outcome: Assessment of TESE and Other Surgical Sperm Retrieval Methods

Contact Info

Product

Resources

About