Topographic organization of medial pulvinar connections with the prefrontal cortex in the rhesus monkey

Romanski, Lizabeth M.; Giguere, Matthew J.; Bates, Julianna F.; Goldman‐Rakic, P. S.

doi:10.1002/(sici)1096-9861(19970317)379:3<313::aid-cne1>3.0.co;2-6

Cited by 279 publications

(229 citation statements)

References 92 publications

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“…However, these cytoarchitectonically defined divisions do not correspond well to divisions based on connectivity, neurochemistry, or electrophysiological properties (Gutierrez et al, 1995;Stepniewska and Kaas, 1997;Adams et al, 2000). The PuL and PuI have widespread connections with visual cortical association areas (Romanski et al, 1997). Moreover, the PuI receives input from the superior colliculus, which seems to function as a second route of visual input to the cortex (Stepniewska and Kaas, 1997;Weller et al, 2002).…”

Section: Gene Expression In Afferent Regions Of the Pfc-pulvinarsupporting

confidence: 79%

“…Therefore, to facilitate the resolution of this issue with a genetic approach, we decided to study molecular markers expressed in marmoset pulvinar showing areal identities. The pulvinar has strong connections with the cortex and can be divided anatomically into medial (PuM), lateral (PuL), inferior (PuI), and anterior (PuA) regions (Romanski et al, 1997) ( Fig. 1 A).…”

Section: Gene Expression In Afferent Regions Of the Pfc-pulvinarmentioning

confidence: 52%

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Comparative Anatomy of Marmoset and Mouse Cortex from Genomic Expression

et al. 2012

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Advances in mouse neural circuit genetics, brain atlases, and behavioral assays provide a powerful system for modeling the genetic basis of cognition and psychiatric disease. However, a critical limitation of this approach is how to achieve concordance of mouse neurobiology with the ultimate goal of understanding the human brain. Previously, the common marmoset has shown promise as a genetic model system toward the linking of mouse and human studies. However, the advent of marmoset transgenic approaches will require an understanding of developmental principles in marmoset compared to mouse. In this study, we used gene expression analysis in marmoset brain to pose a series of fundamental questions on cortical development and evolution for direct comparison to existing mouse brain atlas expression data. Most genes showed reliable conservation of expression between marmoset and mouse. However, certain markers had strikingly divergent expression patterns. The lateral geniculate nucleus and pulvinar in the thalamus showed diversification of genetic organization between marmoset and mouse, suggesting they share some similarity. In contrast, gene expression patterns in early visual cortical areas showed marmoset-specific expression. In prefrontal cortex, some markers labeled architectonic areas and layers distinct between mouse and marmoset. Core hippocampus was conserved, while afferent areas showed divergence. Together, these results indicate that existing cortical areas are genetically conserved between marmoset and mouse, while differences in areal parcellation, afferent diversification, and layer complexity are associated with specific genes. Collectively, we propose that gene expression patterns in marmoset brain reveal important clues to the principles underlying the molecular evolution of cortical and cognitive expansion.

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Section: Gene Expression In Afferent Regions Of the Pfc-pulvinarsupporting

confidence: 79%

Section: Gene Expression In Afferent Regions Of the Pfc-pulvinarmentioning

confidence: 52%

Comparative Anatomy of Marmoset and Mouse Cortex from Genomic Expression

et al. 2012

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“…The majority of volume loss was found in the mediodorsal nucleus and the pulvina. In fact, it is well-known that the mediodorsal nucleus and the pulvina are heavily connected to the prefrontal cortex (Goldman-Rakic & Porrino, 1985;Romanski, Giguere, Bates, & Goldman-Rakic, 1997), a key region in which TBI survivors frequently show structural and functional alterations. Our results also agree well with the post-mortem neuropathologic studies reporting thalamic damage in patients in a vegetative state after head injury (Adams, Graham, & Jennett, 2000;Graham, Maxwell, Adams, & Jennett, 2005;Kinney & Samuels, 1994).…”

Section: Discussionmentioning

confidence: 99%

Structural consequences of diffuse traumatic brain injury: A large deformation tensor-based morphometry study

et al. 2008

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Traumatic brain injury (TBI) is one of the most common causes of long-term disability. Despite the importance of identifying neuropathology in individuals with chronic TBI, methodological challenges posed at the stage of inter-subject image registration have hampered previous voxel-based MRI studies from providing a clear pattern of structural atrophy after TBI. We used a novel symmetric diffeomorphic image normalization method to conduct a tensor-based morphometry (TBM) study of TBI. The key advantage of this method is that it simultaneously estimates an optimal template brain and topology preserving deformations between this template and individual subject brains. Detailed patterns of atrophies are then revealed by statistically contrasting control and subject deformations to the template space. Participants were 29 survivors of TBI and 20 control subjects who were matched in terms of age, gender, education, and ethnicity. Localized volume losses were found most prominently in white matter regions and the subcortical nuclei including the thalamus, the midbrain, the corpus callosum, the mid-and posterior cingulate cortices, and the caudate. Significant voxel-wise volume loss clusters were also detected in the cerebellum and the frontal/ temporal neocortices. Volume enlargements were identified largely in ventricular regions. A similar pattern of results was observed in a subgroup analysis where we restricted our analysis to the 17 TBI participants who had no macroscopic focal lesions (total lesion volume> 1.5 cm 3 ). The current study confirms, extends, and partly challenges previous structural MRI studies in chronic TBI. By demonstrating that a large deformation image registration technique can be successfully combined with TBM to identify TBI-induced diffuse structural changes with greater precision, our approach is expected to increase the sensitivity of future studies examining brain-behavior relationships in the TBI population.

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“…The pulvinar nucleus, among other associative thalamic nuclei, is a good candidate to play such an integrative role, based on its connectivity with numerous cortical areas (e.g. Romanski et al, 1997;Hackett et al, 1998;Gutierrez et al, 2000) and on electrophysiological studies (Yirmiya and Hocherman, 1987;Gattass et al, 1979). …”

Section: Role Of the Thalamusmentioning

confidence: 99%

Multisensory anatomical pathways

2009

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In order to interact with the multisensory world that surrounds us, we must integrate various sources of sensory information (vision, hearing, touch. . .). A fundamental question is thus how the brain integrates the separate elements of an object defined by several sensory components to form a unified percept. The superior colliculus was the main model for studying multisensory integration. At the cortical level, until recently, multisensory integration appeared to be a characteristic attributed to high-level association regions. First, we describe recently observed direct cortico-cortical connections between different sensory cortical areas in the non-human primate and discuss the potential role of these connections. Then, we show that the projections between different sensory and motor cortical areas and the thalamus enabled us to highlight the existence of thalamic nuclei that, by their connections, may represent an alternative pathway for information transfer between different sensory and/or motor cortical areas. The thalamus is in position to allow a faster transfer and even an integration of information across modalities. Finally, we discuss the role of these non-specific connections regarding behavioral evidence in the monkey and recent electrophysiological evidence in the primary cortical sensory areas.

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Topographic organization of medial pulvinar connections with the prefrontal cortex in the rhesus monkey

Cited by 279 publications

References 92 publications

Comparative Anatomy of Marmoset and Mouse Cortex from Genomic Expression

Comparative Anatomy of Marmoset and Mouse Cortex from Genomic Expression

Structural consequences of diffuse traumatic brain injury: A large deformation tensor-based morphometry study

Multisensory anatomical pathways

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