Topographic patterns of retinal lesions in multiple evanescent white dot syndrome

Abstract

Purpose To demonstrate different topographic distributions of multiple-evanescent white dot syndrome (MEWDS) and secondary MEWDS disease and to describe possible associations. Methods Clinical evaluation and multimodal retinal imaging in 27 subjects with MEWDS (29 discrete episodes of MEWDS). Ophthalmic assessment included best-corrected visual acuity testing and multimodal retinal imaging with OCT, blue-light autofluorescence, fluorescein and indocyanine green angiography, fundus photography, and widefield pseudocolor and autofluorescence fundus imaging. Results The topographic distribution of MEWDS lesions was centered on or around the optic disc (n = 17, 59%), centered on the macula (n = 7, 24%), sectoral (n = 2, 7%), or was indeterminate (n = 3, 10%). The MEWDS episodes either occurred in the absence (‘primary MEWDS’; n = 14, 48%) or presence of concurrent chorioretinal pathology (‘secondary MEWDS’; n = 15, 52%). In patients with the latter, MEWDS lesions were often centered around a coexisting chorioretinal lesion. The majority of patients in both groups experienced resolution of their symptoms and retinal changes on multimodal imaging by 3 months. Conclusions Distinct distributions of MEWDS lesions were identified. MEWDS may occur in tandem with other chorioretinal pathology, which may impact the topography of MEWDS lesions.

Photoreceptor Integrity in MEWDS: Longitudinal Structure-Function Correlations

“… 25 Consistent with earlier studies, our cohort also presented diversity in visual acuity at onset. 5 , 26 The integration of MP into our investigation enhanced the comprehension of functional deficits in this disease.…”

Centrifugal progression of retinal lesions in the early evolution of multiple evanescent white dot syndrome

“…Multimodal imaging is often essential in confirming the diagnosis of multiple evanescent white dot syndrome (MEWDS). Fundus autofluorescence (FAF) imaging appears to be particularly sensitive in detecting MEWDS lesions and may best be used to illustrate the extent and topographic distribution of MEWDS lesions [ 1 ]. Non-invasive ultra-widefield FAF imaging enables safe and quick repeat imaging, often does not require pupil dilation, and avoids the potential risks associated with angiography.…”