Topographical Correlation Between Macular Layer Thickness and Clockwise Circumpapillary Retinal Nerve Fiber Layer Sectors in Patients with Normal Tension Glaucoma

Omodaka, Kazuko; Yokoyama, Yû; Shiga, Yukihiro; Inoue, Maki; Takahashi, S.; Tsuda, S.; Maruyama, Kouichi; Nakazawa, Toru

doi:10.3109/02713683.2014.956371

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…But children are often unable to perform reliable visual fields and it is necessary to search for an alternative surrogate marker for visual loss for both diagnosis and follow-up. Furthermore, it seems that in chronic compressive neuropathies, ganglion cell loss can take place before visual field deficits [ 17 – 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Yum et al evaluated the detection rate of abnormal colour codes on GCC sector maps in 46 patients with pituitary adenoma; an abnormal yellow colour code was found in the inferonasal sector 34 (73.9%), followed by the superonasal 29 (63.0%) and inferior 29 (63.0%) sectors. Furthermore, analysis of the GCC sector maps revealed that 25% of preperimetric eyes in patients with pituitary adenomas had an abnormal yellow or red colour code in the inferonasal sector [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

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Macular ganglion cell complex thinning in children with visual field defects due to central nervous system pathology

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Henríquez-Recine

Contreras

et al. 2019

Eye

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Purpose To study the relationship between macular ganglion cell complex (GCC) thickness and visual field defects (VFD) caused by central nervous system (CNS) lesions in children and evaluate the possibility of predicting VFD according to GCC maps. Methods The GCC maps of a group of children with VFD due to CNS lesions with respect of the vertical meridian in at least one eye (study group), as well as of children with other neuro-ophthalmological problems and healthy children were presented to two masked evaluators, who were asked to predict the patients’ VFD on the basis of GCC damage: the evaluators classified VFD as normal, hemianopia (homonymous or heteronymous) or diffuse. Results Seventeen patients were included in the study group, with a median age of 12 years. Fifteen had brain tumours and two epilepsy. The mean MD of the affected hemifields was −26.00 dB (SD 7.89 dB) versus −5.51 dB (SD 3.52 dB) for the nonaffected hemifields, p < 0.001. The mean GCC thickness was of 56.04 μm (SD 11.95 μm) in the affected hemiretinas versus 74.31 μm (SD 10.64 μm) for the non-affected, p < 0.001. Kappa coefficients between VFD and those estimated by the evaluators were 0.705 and 0.658 ( p < 0.001) for evaluators 1 and 2. Conclusions GCC thickness can reflect damage to the visual pathway and GCC maps may be useful to identify chiasmal and retrochiasmal lesions, since GCC atrophy in most of these cases respects the vertical meridian. GCC maps might be used as a surrogate marker for visual damage in patients unable to perform perimetry.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Macular ganglion cell complex thinning in children with visual field defects due to central nervous system pathology

Noval

Henríquez-Recine

Contreras

et al. 2019

Eye

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“…Thus, SS-OCT has led to significant improvements in the observation of deep areas of the optic nerve head in glaucoma patients [ 12 , 17 , 18 ]. Recently, a new OCT image processing technique has enabled us to assess the axonal tract of the retinal ganglion cells [ 19 ]. In this technique, the curve of the inner limiting membrane (ILM) in OCT B-scan images is flattened through software image correction, and en-face images are then reconstructed from the flattened B-scans.…”

Section: Introductionmentioning

confidence: 99%

“…In this technique, the curve of the inner limiting membrane (ILM) in OCT B-scan images is flattened through software image correction, and en-face images are then reconstructed from the flattened B-scans. In a previous report we used this technique to demonstrate that in patients with glaucoma, visible damage to the macula in SS-OCT images was associated with the anatomical trajectory of nerve fiber defects [ 19 ]. Thus, SS-OCT promises to improve assessment of RNFLDs by allowing the quantification of layer thickness and permitting stable fixation and en face analysis of RNFLDs with SS-OCT has published before [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of retinal nerve fiber layer defect using wide-field en-face swept-source OCT images by applying the inner limiting membrane flattening

et al. 2017

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PurposeThe assessment of retinal nerve fiber layer defects (RNFLDs) is a useful part of glaucoma care. Here, we obtained en-face images of retinal layers below the inner limiting membrane (ILM) with swept source-optical coherence tomography (SS-OCT), and measured RNFLD angle with new software.MethodsThis study included 105 eyes of 105 normal tension glaucoma (NTG) patients (age, 59.8 ± 13.2). Exclusion criteria were best-corrected visual acuity < 0.5, axial length > 28 mm, non-glaucoma ocular disease, and systemic disease affecting the visual field. We obtained 12 x 9 mm 3D volume scans centered on the macula with SS-OCT (DRI OCT-1, Topcon), and from these scans, created 3 averaged en-face images, each comprising 7 horizontal en-face images (total thickness: 18.2 μm). We labeled these averaged images, according to their depth below the ILM, as en-face images 1 (shallowest), 2 (middle) and 3 (deepest). In each image, a circle was drawn centered on the disc, with a radius of half the distance between the centers of the disc and macula. The investigator marked points where the edge of the RNFLD intersected this circle, and RNFLD angle (RNFLDA) was calculated with new software. Finally, we analyzed the association between RNFLDA, cpRNFLT, weighted RGC count (wrgc) and Humphrey field analyzer (HFA)-measured mean deviation (MD) and hemifield total deviation (TD), both overall and in each hemifield.ResultsEn-face image 2 had the highest interclass reproducibility for measuring RNFLDA (intra-rater intraclass correlation coefficient (ICC): 0.988, inter-rater ICC: 0.962). The correlation coefficients with RNFLDA were: HFA MD, -0.60; superior TD, -0.73; inferior TD, -0.69; overall cpRNFLT, -0.27; superior hemifield cpRNFLT, -0.39; and inferior hemifield cpRNFLT, -0.53 (all p<0.001).ConclusionsRNFLDA measured in SS-OCT images had high reproducibility and was correlated to glaucoma severity. Our new method may be a valuable future part of glaucoma care.

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“…This study measured the correlations between mRNFL thickness (mRNFLT), mGCIPL thickness (mGCIPLT) and cpRNFLT at each point on a grid overlaid on OCT scans of the macula, identified clusters of abnormal points, and then evaluated the potential of these clusters to reveal structural changes in the macula. Previously, we reported that sectors of the macular map could reveal structural changes in eyes with mild or moderate NTG (101 eyes) [ 28 ]. Here, we extended this analysis with a new data set of 117 eyes of 117 cases that included cases of advanced NTG, and identified sectors of the macular map that depended on the axonal tract.…”

Section: Introductionmentioning

confidence: 99%

Usefulness of axonal tract-dependent OCT macular sectors for evaluating structural change in normal-tension glaucoma

et al. 2017

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PurposeTo identify sectors of the optical coherence tomography (OCT) macular map that could be used to effectively assess structural progression in patients with normal-tension glaucoma (NTG).MethodsThis study examined 117 eyes of 117 NTG patients to establish axonal tract-dependent macular sectors, and also examined a separate group of 122 eyes of 81 NTG patients to evaluate the ability of these sectors to reveal glaucoma progression. Longitudinal data, including macular maps from at least 5 OCT examinations performed over at least 2 years, was available for all patients in this group. Circumpapillary retinal nerve fiber layer thickness (cpRNFLT), temporal clockwise sector scans (from 7 to 11 o’clock), macular retinal nerve fiber layer thickness (mRNFLT), and macular ganglion cell layer plus inner plexiform layer thickness (mGCIPLT) were measured with spectral-domain OCT (3D OCT-2000, TOPCON). The axonal tract-dependent macular sectors were identified by calculating Spearman’s rank correlation coefficient for each point on a grid overlaid on the macular map and cpRNFLT in each clockwise scan sector. Trend and event analyses for the slope of progression in each sector and macular map were performed. Visual field progression in the macula was defined by the presence of more than 2 progressive test points in the 16 central test points of the Humphrey field analyzer SITA standard 24–2 program, evaluated with Progressor software.ResultsThe slope of progression in the entire macular area was -0.22 ± 0.58 μm/year for mRNFLT and -0.35 ± 0.52 μm/year for mGCIPLT. The fastest-progressing mRNFLT sector (-1.00 ± 0.84 μm/year, p < 0.001) and mGCIPLT sector (-1.16 ± 0.63 μm/year, p < 0.001) progressed significantly faster than the overall macula. Classifying patients according to visual field progression showed that baseline mRNFLT in the inferior hemifield, 7 and 8 o’clock sectors, as well as baseline mGCIPLT in the overall macular map, inferior hemifield, and 8 o’clock sector, were significantly lower in progressors (22 eyes) than non-progressors (100 eyes). There were significant differences in mRNFLT slope in 8 o’clock sector and in the fastest progressing sector in progressors and non-progressors, but mGCIPLT did not differ, even in the fastest-progressing sector. Event analysis showed that progression occurred most frequently in inferior mRNFLT and superior mGCIPLT in this study.ConclusionAxonal tract-dependent OCT macular sectors could effectively reveal structural change in patients with NTG. Furthermore, mRNFLT slope was consistent with visual field progression. This method promises to open new avenues for the OCT-based evaluation of glaucoma progression.

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Topographical Correlation Between Macular Layer Thickness and Clockwise Circumpapillary Retinal Nerve Fiber Layer Sectors in Patients with Normal Tension Glaucoma

Abstract: The identification of these topographical macular areas, and the different layouts in the mRNFL and the mGCL + IPL, may increase the accuracy of clinical research on NTG.

Cited by 7 publications

References 29 publications

Macular ganglion cell complex thinning in children with visual field defects due to central nervous system pathology

Macular ganglion cell complex thinning in children with visual field defects due to central nervous system pathology

Evaluation of retinal nerve fiber layer defect using wide-field en-face swept-source OCT images by applying the inner limiting membrane flattening

Usefulness of axonal tract-dependent OCT macular sectors for evaluating structural change in normal-tension glaucoma

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