Topographical differences in white matter hyperintensity burden and cognition in aging, MCI, and AD

Kamal, Farooq; Morrison, Cassandra; Maranzano, Josefina; Zeighami, Yashar; Dadar, Mahsa

doi:10.1101/2022.04.20.22274087

Cited by 3 publications

(4 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With respect to executive functioning, males had a less steep slope in parietal and occipital regions, indicating less cognitive change in those regions associated with WMHs. Previous research also observed that WMHs are associated with change in memory performance in NCs, MCI, and AD 44 . Similarly, we observed that lower memory performance (i.e., high scores in RAVLT percent forgetting, and low scores in RAVLT immediate and learning) was associated with increased WMH accumulation in females.…”

Section: Discussionsupporting

confidence: 85%

“…For the purposes of the current study, specific cognitive tests were chosen to examine multiple cognitive domains known to be associated with WMHs. Global cognition, 41,42 executive functioning, 42,43 memory, 44 and functional status 15 have all been previously observed to be associated with WMH burden. For those reasons, we examined the relationship between WMHs and global cognition (CDR‐SB), executive functioning (Trail‐Making Test Part B [TMT‐B]), Rey Auditory Verbal Learning Test (RAVLT), and functional status in abilities to complete activities of daily living (Functional Activities Questionnaire [FAQ]).…”

Section: Methodsmentioning

confidence: 89%

Section: Cognitive Measuresmentioning

confidence: 99%

See 2 more Smart Citations

Sex differences in risk factors, burden, and outcomes of cerebrovascular disease in Alzheimer's disease populations

Morrison,

Dadar,

Collins

2023

Alzheimer's & Dementia

Self Cite

View full text Add to dashboard Cite

BACKGROUNDWhite matter hyperintensities (WMHs) are associated with cognitive decline and progression to mild cognitive impairment (MCI) and dementia. It remains unclear if sex differences influence WMH progression or the relationship between WMH and cognition.METHODSLinear mixed models examined the relationship between risk factors, WMHs, and cognition in males and females.RESULTSMales exhibited increased WMH progression in occipital, but lower progression in frontal, total, and deep than females. For males, history of hypertension was the strongest contributor, while in females, the vascular composite was the strongest contributor to WMH burden. WMH burden was more strongly associated with decreases in global cognition, executive functioning, memory, and functional activities in females than males.DISCUSSIONControlling vascular risk factors may reduce WMH in both males and females. For males, targeting hypertension may be most important to reduce WMHs. The results have implications for therapies/interventions targeting cerebrovascular pathology and subsequent cognitive decline.HIGHLIGHTS Hypertension is the main vascular risk factor associated with WMH in males A combination of vascular risk factors contributes to WMH burden in females Only small WMH burden differences were observed between sexes Females’ cognition was more negatively impacted by WMH burden than males Females with WMHs may have less resilience to future pathology

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Methodsmentioning

confidence: 89%

See 1 more Smart Citation

Sex differences in risk factors, burden, and outcomes of cerebrovascular disease in Alzheimer's disease populations

Morrison,

Dadar,

Collins

2023

Alzheimer's & Dementia

Self Cite

View full text Add to dashboard Cite

show abstract

“…WMHs are used as a proxy for cerebrovascular disease, a known contributor for cognitive decline and dementia (Abraham et al, 2016; Tamura & Araki, 2015; Van Der Flier et al, 2018). High WMH burden is associated with increased cognitive decline in MCI (Hirao et al, 2021; Kamal et al, 2022; Kim et al, 2015; Li et al, 2016) and increased rate of progression from MCI to dementia (Dadar et al, 2019). When observing pMCI in Parkinson’s disease (PD) dementia, people with PD-MCI who progressed to Parkinson’s disease dementia, at least 24 months later, had higher WMH volumes compared to PD-sMCI (Sunwoo et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Differential WMH progression trajectories in progressive and stable mild cognitive impairment

Kamal

Morrison

Maranzano

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Pathological brain changes such as white matter hyperintensities (WMHs) occur with increased age and contribute to cognitive decline. Current research is still unclear regarding the association of amyloid positivity with WMH burden and progression to dementia in people with mild cognitive impairment (MCI). Methods: This study examined whether WMH burden increases differently in both amyloid-negative (AB-) and amyloid-positive (AB+) people with MCI who either remain stable or progress to dementia. We also examined regional WMHs differences in all groups: amyloid positive (AB+) progressor, amyloid negative (AB-) progressor, amyloid positive (AB+) stable, and amyloid negative (AB-) stable. MCI participants from the Alzheimers Disease Neuroimaging Initiative were included if they had APOE4 status and if they had amyloid measures to determine amyloid status (i.e., positive, or negative). A total of 820 MCI participants that had APOE4 status and amyloid measures were included in the study with 5054 follow-up time points over a maximum period of 13 years with an average of 5.7 follow-up timepoints per participant. Linear mixed-effects models were used to examine group differences in global and regional WMHs. Results: People who were AB- stable had lower baseline WMHs compared to both AB+ progressors and AB+ stable across all regions. When examining change over time, compared to AB- stable, all groups had steeper change in WMH burden with AB+ progressors having the largest change (largest increase in WMH burden over time). Conclusion: These findings suggest that WMH progression is a contributing factor to conversion to dementia both in amyloid-positive and negative people with MCI.

show abstract

Racial differences in white matter hyperintensity burden in older adults

Morrison¹,

Dadar²,

Manera³

et al. 2023

Neurobiology of Aging

View full text Add to dashboard Cite

Topographical differences in white matter hyperintensity burden and cognition in aging, MCI, and AD

Cited by 3 publications

References 47 publications

Sex differences in risk factors, burden, and outcomes of cerebrovascular disease in Alzheimer's disease populations

Sex differences in risk factors, burden, and outcomes of cerebrovascular disease in Alzheimer's disease populations

Differential WMH progression trajectories in progressive and stable mild cognitive impairment

Racial differences in white matter hyperintensity burden in older adults

Contact Info

Product

Resources

About