Topographical representation of odor hedonics in the olfactory bulb

Kermen, Florence; Midroit, Maëllie; Kuczewski, Nicola; Forest, Jérémy; Thévenet, M; Sacquet, Joëlle; Benetollo, Claire; Richard, Marion; Didier, Anne; Mandairon, Nathalie

doi:10.1038/nn.4317

Cited by 40 publications

(42 citation statements)

References 26 publications

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“…Recent data demonstrates that nearly all odors elicit simple approach or avoidance to some degree in mice, with a few odors (like TMT, female urine and 2-PE) driving stronger (but still relatively modest) biases (Kermen et al, 2016; Root et al, 2014; Saraiva et al, 2016; Wiltschko et al, 2015). These observations, taken with the results reported here, suggest a third model, one in which the plCoA can both innately and flexibly assign odors to some degree of behavioral attraction or avoidance (Figure 8C).…”

Section: Discussionmentioning

confidence: 99%

Population Coding in an Innately Relevant Olfactory Area

Iurilli

Datta

2017

Neuron

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Different olfactory cortical regions are thought to harbor distinct sensory representations, enabling each area to play a unique role in odor perception and behavior. In the piriform cortex (PCx), spatially-dispersed sensory inputs evoke activity in distributed ensembles of neurons that act as substrates for odor learning. In contrast, the posterolateral cortical amygdala (plCoA) receives hardwired inputs that link specific odor cues to innate olfactory behaviors. Here we show that, despite stark differences in the patterning of plCoA and PCx inputs, odor-evoked neural ensembles in both areas are equally capable of discriminating odors, and exhibit similar odor tuning, reliability and correlation structure. These results demonstrate that brain regions mediating odor-driven innate behaviors can, like brain areas involved in odor learning, represent odor objects using distributive population codes; these findings suggest both alternative mechanisms for the generation of innate odor-driven behaviors and additional roles for the plCoA in odor perception.

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Section: Discussionmentioning

confidence: 99%

Population Coding in an Innately Relevant Olfactory Area

Iurilli

Datta

2017

Neuron

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“…For example, the rodent olfactory bulb response to food odor is strongly modulated by hunger and satiety (Palouzier-Paulignan et al, 2012). This top-down input may contribute to the recent findings of odor hedonic valence being encoded in the olfactory bulb of both rodents (Kermen et al, 2016) and humans (Iravani et al, in preparation), or that information may be extracted from olfactory sensory neuron input directly by the bulb.…”

Section: Neural Circuits and Odor Perceptionmentioning

confidence: 95%

Behavioral and Neurobiological Convergence of Odor, Mood and Emotion: A Review

Kontaris¹,

East

Wilson

2020

Front. Behav. Neurosci.

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The affective state is the combination of emotion and mood, with mood reflecting a running average of sequential emotional events together with an underlying internal affective state. There is now extensive evidence that odors can overtly or subliminally modulate mood and emotion. Relying primarily on neurobiological literature, here we review what is known about how odors can affect emotions/moods and how emotions/moods may affect odor perception. We take the approach that form can provide insight into function by reviewing major brain regions and neural circuits underlying emotion and mood, and then reviewing the olfactory pathway in the context of that emotion/mood network. We highlight the extensive neuroanatomical opportunities for odor-emotion/mood convergence, as well as functional data demonstrating reciprocal interactions between these processes. Finally, we explore how the odoremotion/mood interplay is, or could be, used in medical and/or commercial applications.

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“…Finally, the TAAR domain of the olfactory bulb is required for innate behavioral responses to several ecologically important amines, even though these same odorants can be detected by receptors in the main olfactory system (Figure 5) [84]. Recent data also suggest a global organization to the main olfactory bulb, in which glomeruli that reside more rostrally evoke investigatory behaviors, while those that are more caudal evoke aversion [111]. Characterizing the mitral cell projections downstream of specific glomeruli may reveal different capacities to influence a variety of central processing or behavioral centers.…”

Section: Segregated Olfactory Pathways As Substrates For Innate Olfacmentioning

confidence: 99%

The Evolving Neural and Genetic Architecture of Vertebrate Olfaction

et al. 2016

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Evolution sculpts the olfactory nervous system in response to the unique sensory challenges facing each species. In vertebrates, dramatic and diverse adaptations to the chemical environment are possible because of the hierarchical structure of the olfactory receptor (OR) gene superfamily: rapid growth or pruning across the OR gene tree accompany major changes in habitat and lifestyle; independent selection on OR subfamilies can permit local adaptation or conserved chemical communication; and genetic variation in single OR genes among thousands can alter odor percepts and behaviors driven by precise chemical cues. However, this genetic flexibility contrasts with the relatively fixed neural architecture of the vertebrate olfactory system, whose slower rate of divergence mandates that new olfactory receptors integrate into segregated and functionally-distinct neural pathways. This organization allows evolution to couple critical chemical signals with selectively advantageous responses, but also constrains relationships between olfactory receptors and behavior. The coevolution of the OR repertoire and the structure of the olfactory system therefore reveals general principles of how the brain solves specific sensory problems and how it adapts to new ones.

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Topographical representation of odor hedonics in the olfactory bulb

Cited by 40 publications

References 26 publications

Population Coding in an Innately Relevant Olfactory Area

Population Coding in an Innately Relevant Olfactory Area

Behavioral and Neurobiological Convergence of Odor, Mood and Emotion: A Review

The Evolving Neural and Genetic Architecture of Vertebrate Olfaction

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