Topographically and Chemically Modified Surfaces for Expansion or Differentiation of Embryonic Stem Cells

Markert, Lotte D’Andrea; Lovmand, Jette; Duch, Mogens; Pedersen, Finn Skou

doi:10.5772/15346

Methodological Advances in the Culture, Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applicatio 2011

DOI: 10.5772/15346

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Topographically and Chemically Modified Surfaces for Expansion or Differentiation of Embryonic Stem Cells

Lotte D’Andrea Markert¹,

Jette Lovmand²,

Mogens Duch³

et al.

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2018

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“…Because cells are interacting with the substrate surface[55,57,58,[60][61][62][63][64][65][66]70], the cells growing on a stiff substrate exhibit greater rigidity[64,67,71], a more organised cellular Comparative heuristic analysis of pristine titanium, Ti6Al4V and Ti6Al7N powders.Biomaterials in Regenerative Medicinecytoskeleton[55,59,[63][64][65][66][67] and greater flattening[55, 57, 60, 63-66, 70, 72] than those growing on a more elastic substrate. Cells, especially fibroblasts and cells of smooth muscles, exhibit mechanotaxis (durotaxis), moving towards a substrate with greater rigidity…”

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confidence: 99%

Microporous Titanium-Based Materials Coated by Biocompatible Thin Films

Dobrzańska-Danikiewicz¹,

Dobrzański²,

Szindler³

et al. 2018

Biomaterials in Regenerative Medicine

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This chapter presents the outcomes of numerous own works concerning constructional solutions and fabrication technologies of a new generation of custom, original, hybrid, microporous high-strength engineering and biological materials with microporous rigid titanium and Ti6Al4V alloy skeletons manufactured by Selective Laser Sintering (SLS), whose pores are filled with living cells. The so constructed and fabricated implants, in the connection zone with bone stumps, contain a porous zone, with surface treatment inside pores, enabling the living tissues to grow into. As the adhesion and growth of living cells are dependent on the type and characteristic of the substrate it is necessary to create the most advantageous proliferation conditions of living cells inside the pores of a microporous skeleton made of titanium and Ti6Al4V alloy. In order to improve the proliferation conditions of cells ensured by a fully compatible substrate, internal coatings with TiO 2 , Al 2 O 3 oxides and Ca 10 (PO 4) 6 (OH) 2 hydroxyapatite of the surface of pores of a microporous skeleton made of titanium and Ti6Al4V alloy with SLS was used. Two technologies have been chosen for the deposition of thin coatings onto the internal surfaces of pores: Atomic Layer Deposition (ALD) and the sol-gel of deep coating from the liquid phase.

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mentioning

confidence: 99%

Microporous Titanium-Based Materials Coated by Biocompatible Thin Films

Dobrzańska-Danikiewicz¹,

Dobrzański²,

Szindler³

et al. 2018

Biomaterials in Regenerative Medicine

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Topographically and Chemically Modified Surfaces for Expansion or Differentiation of Embryonic Stem Cells

Cited by 1 publication

References 78 publications

Microporous Titanium-Based Materials Coated by Biocompatible Thin Films

Microporous Titanium-Based Materials Coated by Biocompatible Thin Films

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