The study of the lymphatic system is of interest not only for morphology, but also for physiology and pathology, since it is in the organs and tissues where the lymphatic capillaries are located that metabolism occurs. The lymphatic bed is represented by intramural vessels, regional lymph nodes of the first and second order. The aim of the study was to determine the lymph nodes and vessels involved in the lymph outflow from the lip area in sheep of the Edilbaev breed. The study was conducted at the Department of Animal Anatomy of the St. Petersburg State University of Veterinary Medicine. The material was sheep of the Edilbaevsky breed in the amount of five pieces at the age of one year. As methods, an interstitial (interstitial) injection with cotrust masses in the form of a blue mass of Gerot was used, which was prepared by rubbing 2.0 g of blue oil paint in 30.0 g of gum turpentine. The resulting mass was mixed with 15.0 g of ether and passed through a filter. Before the injection, the sheep's head was placed in warm water for several hours. The injection is carried out with a syringe with thin needles. Contrast masses were injected very slowly, gently massaging the injected area. As a result of our research, we came to the conclusion that the direction of the main lymphatic vessels of the upper lip and the edges of the nasal opening corresponds to the line drawn from the corner of the lips to the mandibular joint; the direction of the diverting lymphatic vessels of the lower lip corresponds to the direction of the free edge of the lower jaw; the main regional lymph nodes for the diverting lymphatic vessels of the lips of the sheep of the Edilbaev breed are the parotid and mandibular and, in isolated cases, the lateral pharyngeal.