Topography of dilated perivascular spaces in subjects from a memory clinic cohort

Martínez-Ramírez, Sergi; Pontes-Neto, Octávio Marques; Dumas, Andrew; Auriel, Eitan; Halpin, Amy; Quimby, Megan; Gurol, M. Edip; Greenberg, Steven M.; Viswanathan, Anand

doi:10.1212/wnl.0b013e31828f1876

Cited by 148 publications

(176 citation statements)

References 29 publications

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“…5,6 In a retrospective multicentre cohort study of 121 patients with ICH, patients with lobar ICH had a higher prevalence of severely dilated PVS in the centrum semiovale compared with patients with nonlobar ICH. 5 Further evidence for a link between CAA and dilated PVS was provided by a study on 89 memory clinic subjects, in which subjects with a high degree of dilated white matter PVS had higher counts of lobar microbleeds, a potential marker of CAA pathology.…”

Section: Discussionmentioning

confidence: 99%

P1‐218: Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces

Veluw

Biessels

Bouvy

et al. 2015

Alzheimer's & Dementia

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Perivascular spaces are an emerging marker of small vessel disease. Perivascular spaces in the centrum semiovale have been associated with cerebral amyloid angiopathy. However, a direct topographical relationship between dilated perivascular spaces and cerebral amyloid angiopathy severity has not been established. We examined this association using post-mortem magnetic resonance imaging in five cases with evidence of cerebral amyloid angiopathy pathology. Juxtacortical perivascular spaces dilation was evaluated on T2 images and related to cerebral amyloid angiopathy severity in overlying cortical areas on 34 tissue sections stained for Amyloid b. Degree of perivascular spaces dilation was significantly associated with cerebral amyloid angiopathy severity (odds ratio ¼ 3.3, 95% confidence interval 1.3-7.9, p ¼ 0.011). Thus, dilated juxtacortical perivascular spaces are a promising neuroimaging marker of cerebral amyloid angiopathy severity.

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Section: Discussionmentioning

confidence: 99%

P1‐218: Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces

Veluw

Biessels

Bouvy

et al. 2015

Alzheimer's & Dementia

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“…The association of AD and increased white matter PVS volume has also been demonstrated using neuroimaging (Ramirez et al, 2015). PVS in the centrum semiovale (CSO-PVS) are associated with CAA-related intracerebral haemorrhage (ICH) (Charidimou et al, 2013b;Charidimou et al, 2014b) and its "haemorrhagic" markers, namely lobar microbleeds (Martinez- Ramirez et al, 2013;Yakushiji et al, 2014) and cortical superficial siderosis (Charidimou et al, 2014a). Indeed, a recent study using post-mortem 7-Tesla MR in CAA-related ICH found an association between juxta-cortical PVS enlargement and the histopathological grade of CAA in the overlying cortex (van Veluw et al, 2015).…”

Section: Mri-visible Perivascular Spaces (Pvs) -Sometimes Termed Vircmentioning

confidence: 96%

“…Whereas enlargement in the basal ganglia (BG-PVS) appears to be associated with markers of arteriolosclerosis, enlargement of PVS in the white matter centrum semi-ovale (CSO-PVS) appears to be associated with cerebral Aβ pathologies, both AD and CAA (Charidimou et al, 2013a;Charidimou et al, 2013b;Martinez-Ramirez et al, 2013). Neuropathological studies have demonstrated that the frequency and severity of white matter PVS is greater in AD than controls, and this was associated with brain Aβ load, severity of CAA and Apolipoprotein E (APOE) ε4 presence (Roher et al, 2003).…”

Section: Mri-visible Perivascular Spaces (Pvs) -Sometimes Termed Vircmentioning

confidence: 99%

MRI-visible perivascular space location is associated with Alzheimer's disease independently of amyloid burden

Banerjee

Kim

Fox

et al. 2017

Brain

201

216

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MRI-visible perivascular spaces are a neuroimaging marker of cerebral small vessel disease.Their location may relate to the type of underlying small vessel pathology: those in the white matter centrum semi-ovale have been associated with cerebral amyloid angiopathy, whilst those in the basal ganglia have been associated with deep perforating artery arteriolosclerosis.Since cerebral amyloid angiopathy is an almost invariable pathological finding in Alzheimer's disease, we hypothesized that MRI-visible perivascular spaces in the centrum semi-ovale would be associated with a clinical diagnosis of Alzheimer's disease, whereas those in the basal ganglia would be associated with subcortical vascular cognitive impairment. We also hypothesised that MRI-visible perivascular spaces in the centrum semiovale would be associated with brain amyloid burden, as detected by amyloid-PET using subcortical vascular cognitive impairment n=116) with standardised MRI and PiB-PET imaging were included. MRI-visible perivascular spaces were rated using a validated 4-point visual rating scale, and then categorised by severity ("none/mild", "moderate" or "frequent/severe").

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“…69,72 Patients with SVD often have enlargement of the Virchow-Robin perivascular spaces, 73,74 which are associated with amyloid angiopathy, hypertension, and lobar microbleeds. 75,76 At this time, the clinical significance of the dilatation of the perivascular spaces remains to be determined.…”

Section: Pathophysiology Of White-matter Injury In Small Vessel Diseasementioning

confidence: 99%

Consensus statement for diagnosis of subcortical small vessel disease

Rosenberg

Wallin

Wardlaw

et al. 2015

J Cereb Blood Flow Metab

184

132

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Vascular cognitive impairment (VCI) is the diagnostic term used to describe a heterogeneous group of sporadic and hereditary diseases of the large and small blood vessels. Subcortical small vessel disease (SVD) leads to lacunar infarcts and progressive damage to the white matter. Patients with progressive damage to the white matter, referred to as Binswanger's disease (BD), constitute a spectrum from pure vascular disease to a mixture with neurodegenerative changes. Binswanger's disease patients are a relatively homogeneous subgroup with hypoxic hypoperfusion, lacunar infarcts, and inflammation that act synergistically to disrupt the blood-brain barrier (BBB) and break down myelin. Identification of this subgroup can be facilitated by multimodal disease markers obtained from clinical, cerebrospinal fluid, neuropsychological, and imaging studies. This consensus statement identifies a potential set of biomarkers based on underlying pathologic changes that could facilitate diagnosis and aid patient selection for future collaborative treatment trials.

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Topography of dilated perivascular spaces in subjects from a memory clinic cohort

Cited by 148 publications

References 29 publications

P1‐218: Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces

P1‐218: Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces

MRI-visible perivascular space location is associated with Alzheimer's disease independently of amyloid burden

Consensus statement for diagnosis of subcortical small vessel disease

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