Topography of the deep cortex of the lymph nodes of various mammalian species

Bélisle, Claude; Sainte-Marie, G

doi:10.1002/ar.1092010311

Cited by 28 publications

(13 citation statements)

References 6 publications

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“…Their description of a ''lobule'' in the rat lymph node is compatible with ours; however, their statement that the mouse lymph node has a single ''lobule'' disagrees with observations in Bélisle and Sainte-Marie (1981a) . Gretz 1 Note that this review uses the terminology we have adopted over the years to designate lymph node components; other terms may be used when necessary but are put into quotation marks.…”

Section: Morphology Of the Lymph Nodesupporting

confidence: 70%

“…Though our work focused on the rat, nodal morphology is basically similar among eight examined mammal species including the human and the mouse (Bélisle and Sainte-Marie, 1981a). However, interpretation of single lymph node sections can be complicated by: (1) irregular occurrence, but more often in some species and in large than in small lymph nodes, of variably developed connective tissue trabeculae or septae arising from the capsule, which may partition a lymph node to various extents (Yoffey and Courtice, 1970); (2) changes in the appearance of structural components with cutting angle because lymph node and compartment architectures are non-uniform; (3) difficulty of clearly outlining the diverse nodal lymphoid components in standard tissue sections; and (4) intrinsic and extensive variability in the number, size, shape, and content of these components within and among compartments, lymph nodes, and individuals (see for example, the extreme variability in lymphocyte content of the subcapsular sinus described in Sainte-Marie et al, 1982;Sainte-Marie and Peng, 1990b;Sainte-Marie, 2001).…”

Section: Morphology Of the Lymph Nodementioning

confidence: 99%

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The Lymph Node Revisited: Development, Morphology, Functioning, and Role in Triggering Primary Immune Responses

Sainte-Marie

2010

The Anatomical Record

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Scenarios have been proposed to explain how lymphoid components of a lymph node favor the encounter of a drained antigen with a circulating competent naïve lymphocyte to trigger a primary immune response. However, these scenarios rest on incorrect concepts about the organ. This situation resulted from a loss of interest for studies on in vivo lymphoid organs due to a widespread switch, decades ago, to work on suspended lymphoid cells. However, an in vivo holistic study of the organ continued in our laboratory. The present review synthesizes resulting knowledge on lymph node morphology and global functioning. We show that the opening of an afferent lymphatic vessel into the subcapsular sinus is the focal point from which the related portion of a lymph node-a node compartment-is developed. As to the formation of a compartment's lymphoid components, it is neonatally orchestrated by the dichotomic nature and distribution of antigens in this subcapsular sinus, which determines a dichotomic recruitment of circulating cells and the compartment's architectural complexity. The transport process of an antigen from a given tissue territory into restricted sites of the draining compartment further defines its local morphological features and activities, while providing the possibility to reduce the wandering of a short-lived naïve cell through innumerable target-devoid sites. We also explain that the nodal lymphoid components are not implicated in the triggering of primary responses, but are rather products of such responses. Scenarios for the triggering of primary responses, consistent with real node morphology and functioning, are proposed. Anat Rec,

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Section: Morphology Of the Lymph Nodesupporting

confidence: 70%

Section: Morphology Of the Lymph Nodementioning

confidence: 99%

The Lymph Node Revisited: Development, Morphology, Functioning, and Role in Triggering Primary Immune Responses

Sainte-Marie

2010

The Anatomical Record

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“…The cortex of a lymph node is organised into an outer cortex consisting of a network of reticular cells and reticular fibres with the primary and secondary lymphatic nodules, and a deep cortex consisting of diffuse lymphatic tissue. The centre of the lymph node comprised medullary cords arising from the lymphatic tissue of the deep cortex, separated by medullary sinuses (Belisle and Saint-Marie, 1981;Nicander et al, 1993;Junqueira et al, 1995). Between the capsule and the surface of the outer cortex there was a subcapsular sinus for direct receipt of the afferent lymph from the afferent lymphatic vessels.…”

Section: Discussionmentioning

confidence: 99%

Morphology of the lymph nodes in bottlenose dolphin (Tursiops truncatus) and striped dolphin (Stenella coeruleoalba) from the Adriatic Sea

Vuković

Lucić

Gomerčić

et al. 2005

Acta Veterinaria Hungarica

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Morphology of the lymph nodes was examined in six bottlenose dolphins (Tursiops truncatus) and three striped dolphins (Stenella coeruleoalba) from the Adriatic Sea. All animals had been found dead in nature. One group of the nodes was taken from the tracheal branching area and was marked as bifurcational lymph node, and the other group was taken from the mesenteric root and was marked as mesenteric lymph node. Microscopic analysis showed that the lymph nodes in both dolphin species were surrounded by a connective tissue capsule comprising smooth muscle cells. The parenchyma of the mesenteric and bifurcational lymph nodes in bottlenose dolphin was divided into the peripherally situated cortex with the lymphatic nodules and diffuse lymphatic tissue, and the centrally situated medulla structured of the medullary cords separated by the medullary sinuses. These lymph nodes structurally correspond to the lymph nodes in the majority of terrestrial mammals. The mesenteric lymph node of striped dolphin also had a peripherally situated cortex and a centrally positioned medulla as the majority of terrestrial mammals. In the bifurcational lymph nodes of striped dolphin, there was a central dense lymphatic tissue with the lymphatic nodules and a peripheral less dense lymphatic tissue structured of the cell cords and sinuses. The bifurcational lymph node in striped dolphin resembled porcine lymph nodes and belonged to the inverse lymph nodes.

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“…As a result of such findings, we regard the structure as a "deep cortical unit" such as in the mouse or rat relating to the leading role of the immune system which is described by Belisle & Sainte-Marie (1981) 9) , Sainte-Marie et al . We assume that in large animals like dogs or bovines, this structure was achieved as a "unit complex" in which the deep cortex extended continuously with the development of trabeculae.…”

Section: Discussionmentioning

confidence: 99%