Topography of the retinal projection upon the superior colliculus of the cat

Feldon, Steven E.; Feldon, Paul; Kruger, Lawrence

doi:10.1016/0042-6989(70)90111-2

Cited by 312 publications

(67 citation statements)

References 21 publications

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“…Despite SC layers receiving visual afferent inputs from distributed sources, previous tracing studies in the cat have shown that retinal and cortical terminals align along the dorsoventral axis of the SC, such that all layers form overlaid representations of contralateral visual space (Berson 1988a(Berson , 1988bFeldon and Kruger 1970). Reflecting this organization of visual inputs, we observed strong alignment of spatial RFs along each shank.…”

Section: Visual Responses Display Laminar Specificitymentioning

confidence: 53%

Laminar profile of visual response properties in ferret superior colliculus

Stitt

Galindo-Leon

Pieper

et al. 2013

Journal of Neurophysiology

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In the superior colliculus (SC), visual afferent inputs from various sources converge in a highly organized way such that all layers form topographically aligned representations of contralateral external space. Despite this anatomical organization, it remains unclear how the layer-specific termination of different visual input pathways is reflected in the nature of visual response properties and their distribution across layers. To uncover the physiological correlates underlying the laminar organization of the SC, we recorded multiunit and local field potential activity simultaneously from all layers with dual-shank multichannel linear probes. We found that the location of spatial receptive fields was strongly conserved across all visual responsive layers. There was a tendency for receptive field size to increase with depth in the SC, with superficial receptive fields significantly smaller than deep receptive fields. Additionally, superficial layers responded significantly faster than deeper layers to flash stimulation. In some recordings, flash-evoked responses were characterized by the presence of gamma oscillatory activity (40–60 Hz) in multiunit and field potential signals, which was strongest in retinorecipient layers. While SC neurons tended to respond only weakly to full-field drifting gratings, we observed very similar oscillatory responses to the offset of grating stimuli, suggesting gamma oscillations are produced following light offset. Oscillatory spiking activity was highly correlated between horizontally distributed neurons within these layers, with oscillations temporally locked to the stimulus. Together, visual response properties provide physiological evidence reflecting the laminar-specific termination of visual afferent pathways in the SC, most notably characterized by the oscillatory entrainment of superficial neurons.

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Section: Visual Responses Display Laminar Specificitymentioning

confidence: 53%

Laminar profile of visual response properties in ferret superior colliculus

Stitt

Galindo-Leon

Pieper

et al. 2013

Journal of Neurophysiology

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“…Responses of 35 neurons for which there was no doubt that every spike was correctly sorted during offline discrimination (see Materials and Methods) were taken for analysis. The cells were recorded from the rostral half of the superior colliculus, which contains binocular representation of the visual field (Feldon and Kruger, 1970;Lane et al, 1974). All cells had binocular inputs.…”

Section: Resultsmentioning

confidence: 99%

Variability of Visual Responses of Superior Colliculus Neurons Depends on Stimulus Velocity

Mochol

Wójcik²,

Wypych³

et al. 2010

J. Neurosci.

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Visually responding neurons in the superficial, retinorecipient layers of the cat superior colliculus receive input from two primarily parallel information processing channels, Y and W, which is reflected in their velocity response profiles. We quantified the timedependent variability of responses of these neurons to stimuli moving with different velocities by Fano factor (FF) calculated in discrete time windows. The FF for cells responding to low-velocity stimuli, thus receiving W inputs, increased with the increase in the firing rate. In contrast, the dynamics of activity of the cells responding to fast moving stimuli, processed by Y pathway, correlated negatively with FF whether the response was excitatory or suppressive. These observations were tested against several types of surrogate data. Whereas Poisson description failed to reproduce the variability of all collicular responses, the inclusion of secondary structure to the generating point process recovered most of the observed features of responses to fast moving stimuli. Neither model could reproduce the variability of low-velocity responses, which suggests that, in this case, more complex time dependencies need to be taken into account. Our results indicate that Y and W channels may differ in reliability of responses to visual stimulation. Apart from previously reported morphological and physiological differences of the cells belonging to Y and W channels, this is a new feature distinguishing these two pathways.

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“…4), the decrease in firing of most middle-SC cells was interrupted by the increasing discharge, linked to the onset of corrective gaze saccades. Feldon et al, 1970) with numbers showing the recording sites of cells in corresponding panels of the same column. Cells in each column are arranged from top to bottom according to their rostrocaudal location on the map.…”

Section: Overview Of Population Dischargesmentioning

confidence: 99%

Evidence for Gaze Feedback to the Cat Superior Colliculus: Discharges Reflect Gaze Trajectory Perturbations

Matsuo

Bergeron²,

Guitton³

2004

J. Neurosci.

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Rapid coordinated eye-head movements, called saccadic gaze shifts, displace the line of sight from one location to another. A critical structure in the gaze control circuitry is the superior colliculus (SC) of the midbrain, which drives gaze saccades by relaying cortical commands to brainstem eye and head motor circuits. We proposed that the SC lies within a gaze feedback loop and generates an error signal specifying gaze position error (GPE), the distance between target and current gaze positions. We investigated this feedback hypothesis in cats by briefly stopping head motion during large (Ϸ50°) gaze saccades made in the dark. This maneuver interrupted intended gaze saccades and briefly immobilized gaze (a plateau). After brake release, a corrective gaze saccade brought the gaze on goal. In the caudal SC, the firing frequency of a cell gradually increased to a maximum that just preceded the optimal gaze saccade encoded by the position of the cell and then declined back to zero near gaze saccade end. In brake trials, the activity level just preceding a brakeinduced plateau continued steadily during the plateau and waned to zero only near the end of the corrective saccade. The duration of neural activity was stretched to reflect the increased time to target acquisition, and firing frequency during a plateau was proportional to the GPE of the plateau. In comparison, in the rostral SC, the duration of saccade-related pauses in fixation cell activity increased as plateau duration increased. The data show that the cat's SC lies in a gaze feedback loop and that it encodes GPE.

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Topography of the retinal projection upon the superior colliculus of the cat

Cited by 312 publications

References 21 publications

Laminar profile of visual response properties in ferret superior colliculus

Laminar profile of visual response properties in ferret superior colliculus

Variability of Visual Responses of Superior Colliculus Neurons Depends on Stimulus Velocity

Evidence for Gaze Feedback to the Cat Superior Colliculus: Discharges Reflect Gaze Trajectory Perturbations

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