Topography of vestibulocochlear nerve fibers in the posterior cranial fossa

Natout, Mohamad Ali Y.; Terr, Leonid I.; Linthicum, Fred H.; House, William F.

doi:10.1288/00005537-198708000-00013

Cited by 35 publications

(15 citation statements)

References 5 publications

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“…Rasmussen, 1940;Natural and Schuknecht, 1972;Bergstrom, 1973;Richter, 1980 Length 5-7 mm 6 mm F.H. Linthicum, Jr., personal communication Internode distance (distance covered by one Schwann cell) 0.5-1.0 mm 0.75 mm Natout et al, 1987;Schalow, 1989;Vizoso, 1950 A similar display of model parameter estimates is provided in Table II for the 3-hit model. The model-estimated distribution function for the 3-hit model is also included in Fig.…”

Section: Resultsmentioning

confidence: 97%

Exploring the “two‐hit hypothesis” in NF2: Tests of two‐hit and three‐hit models of vestibular schwannoma development

Woods

Friedman

Evans

et al. 2003

Genetic Epidemiology

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Neurofibromatosis 2 (NF2) is a genetic disease that occurs in approximately 1 in 40,000 live births. Almost all affected individuals develop bilateral tumors of Schwann cells that surround the vestibular nerves; these tumors are known as vestibular schwannomas (VS). Evidence from molecular genetic studies suggests that at least two mutations are involved in formation of VS in patients with NF2. Several authors proposed probabilistic models for this process in other tumors, and showed that such models are consistent with incidence data. We evaluated two different probabilistic models for a "2-hit" hypothesis for VS development in NF2 patients, and we present results from fitting these models to incidence data. Molecular evidence does not exclude the possibility that additional hits are necessary for the development of VS, and we also assessed a "3-hit" model for tumor formation. The "3-hit" model fits the data marginally better than one of the "2-hit" models and much better than the other "2-hit" model. Our findings suggest that more than two mutations may be necessary for VS development in NF2 patients.

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Section: Resultsmentioning

confidence: 97%

Exploring the “two‐hit hypothesis” in NF2: Tests of two‐hit and three‐hit models of vestibular schwannoma development

Woods

Friedman

Evans

et al. 2003

Genetic Epidemiology

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“…These results could, however, be explained by Natout et al's anatomo-histological findings (40) of the presence of an overlapping zone between cochlear and vestibular fibers; such an overlapping zone involves vestibular fibers that take up from 16% to 33% of the cochlear nerve. Therefore, persistence of VEMPs following vestibular neurotomy could be due to such vestibular fibers travelling through the cochlear nerve and spared by vestibular nerve section.…”

Section: The Normal Responsementioning

confidence: 82%

Vestibular Evoked Myogenic Potentials in Humans: a Review

Ferber-Viart

Dubreuil²,

Duclaux³

1999

Acta Oto-Laryngologica

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The human vestibule has preserved an ancestral sound sensitivity and it has been suggested that a reflex could originate from this property, thus inducing cervical muscle microcontractions secondary to strong acoustic stimulations. This reflex is assumed to originate in the saccule, the afferent pathways being either the vestibulocochlear nerve or the inferior vestibular nerve, and the efferent pathways the vestibulospinal tract. Averaging these muscular responses allows vestibular evoked myogenic potentials (VEMPs) to be obtained. The responses consist of two alternatively positive and negative successive waves (p13-n23, p33-n43). The characteristics of this reflex are defined in the literature as follows: it has been established that VEMP amplitude depends on muscular tension. All studies give concording evidence that in healthy subjects the first component of VEMP is more consistent than the second. Binaural stimulation is always responsible for responses of greater amplitude than those obtained from monaural stimulation. Following monaural stimulation, however, VEMPs are either of greater amplitude on the muscle ipsilateral to the stimulation or of the same amplitude on both muscles. There is consensus in the literature demonstrating that VEMP amplitude depends on stimulus intensity: the threshold of VEMP occurrence is clearly above auditory level but varies from one individual to the next. In the 1970s, recordings performed in cases of specific audiovestibular defects suggested that the reflex receptor could be the saccule. More recent studies suggest that the cochlea too could be involved in the response. Likewise, while a number of studies tend to demonstrate that VEMPs depend on vestibular integrity, others suggest that afferent pathways could be of both cohlear and vestibular origin. Finally, while it has been suggested that VEMP efferent pathways travel through the vestibulospinal tract, whether it is the lateral or the medial vestibulospinal tract that is concerned remains to be clarified. A few points regarding VEMP receptors and afferent and efferent pathways call for further investigation. They are inaccurate for use in routine vestibular examination. Once precise receptor localization and pathways are clarified, VEMP recording will provide both a straightforward non-invasive exploration of each vestibule independently and an attractive method by which to explore otolithic receptors and vestibulospinal pathways.

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“…вклейке). В целом данные о более высоких значени-ях Area нервных волокон в ВН соответствуют результатам, полученным ранее другими исследователями [14,16,17].…”

Section: результаты и обсуждениеunclassified

“…вклейке). Это наблюдение не согласуется с данными других исследователей, отмечавших в этом отделе ПУН нижнее и даже нижнезаднее расположение КН [1,3,5,16,18,19].…”

Section: результаты и обсуждениеunclassified