2006
DOI: 10.1016/j.humpath.2006.05.008
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Topoisomerase IIα gene amplification in gastric carcinomas: correlation with the HER2 gene. An immunohistochemical, immunoblotting, and multicolor fluorescence in situ hybridization study

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Cited by 40 publications
(36 citation statements)
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“…Nevertheless, rates of TOP2A amplification in the current series were much lower andconsistent with recent investigations-our findings confirm that this phenomenon seems to be primarily linked with HER2 positivity [17,31,32]. Overall, TOP2A aberrations are unlikely to be a determinant of responsiveness to anthracyclines.…”
Section: Discussionsupporting
confidence: 91%
“…Nevertheless, rates of TOP2A amplification in the current series were much lower andconsistent with recent investigations-our findings confirm that this phenomenon seems to be primarily linked with HER2 positivity [17,31,32]. Overall, TOP2A aberrations are unlikely to be a determinant of responsiveness to anthracyclines.…”
Section: Discussionsupporting
confidence: 91%
“…Selective inhibition of MET is known to kill MET-overexpressing gastric cancer cells effectively [14,46] and is the rationale for ongoing clinical trials of MET inhibitors for gastric cancer therapy. Our data also showed overexpression of several genes whose protein products were phosphorylated and have been proposed as useful prognostic markers and/or therapeutic targets for gastric cancer, including EGFR [47], TOP2A [48], minichromosome maintenance 2 (MCM2) [49], erythropoietin-producing hepatocellular (Eph) A2 receptor [50], CTNNB1 [51] and hepatoma-derived growth factor (HDGF) [52]. The data sets also reveal novel overexpressed and phosphorylated proteins whose roles in gastric cancer have yet to be defined, such as EIF2S3, LMNB2, KIF23, SLC7A5/CD98 and MCM3 (supplemental Table 9), although some have been associated with other types of cancers.…”
Section: Discussionsupporting
confidence: 58%
“…37 However, in either tumors, dual-color FISH images of coamplified genes were not simply overlapped signals or repetitive signal doublets. 18,37,38 At the present time, it is most likely that Myc and ERBB2, or Myc and EGFR, amplification occurs simultaneously after translocation, although whether or not this is the only cytogenetic mechanism operating still remains to be elucidated.…”
Section: Discussionmentioning
confidence: 99%
“…FISH has the potential to answer these questions because it can reveal both gene amplification on a cell-by-cell basis and the intranuclear topology of two amplified genes. 18 This study was conducted to assess the exact frequencies of Myc amplification and to clarify the mechanisms of gene amplification of Myc, especially the possible simultaneous amplification with ERBB2 or EGFR in gastric cancers.…”
mentioning
confidence: 99%