We show that a sliding motion between the two layers of a moiré superlattice induces an electric current and realizes a two-dimensional version of the topological Thouless pump when the Fermi energy lies in one of the minigaps. Interestingly, a chiral charge pump, namely, a transverse current induced by the sliding motion, is possible in twisted homobilayers. This result is confirmed by a concrete calculation of the adiabatic current in twisted bilayer graphene. Our work reveals an interesting link between mechanical motion and electricity unique to moiré superlattices, and may find applications in nanogenerators and nanomotors.The emergence of long-wavelength moiré superlattices in van der Waals heterostructures has generated widespread interest in condensed matter physics. These superlattices can strongly modify the low-energy spectrum of charge carriers, giving rise to a wide range of spectacular quantum phenomena such as Hofstadter butterfly [1][2][3], superconductivity [4][5][6], Mott insulators [7,8], and moiré excitons [9][10][11][12]. A notable recent advance in experimental techniques is the demonstration of in situ control of the moiré superlattice in rotatable heterostructures, including twisted bilayer graphene [13] and graphene/BN heterostructures [14]. These results point to the exciting possibility of dynamical control of quantum states in van der Waals heterostructures, in which the moiré superlattice should be treated as a timedependent potential.In a van der Waals heterostructure, the moiré superlattice is formed by incommensurate stacking of atomic layers. A complete description of the stacking requires both the twist angle (θ) and the relative shift (s). In principle, a variation in either θ or s will make the moiré potential time-dependent. However, while varying the twist angle can lead to a drastic change of the moiré potential and hence a strong modification of the electronic structure, a relative shift does not change the overall shape of the moiré superlattice and the static electronic structure is shift independent (for small twist angles) [15][16][17][18][19]. Because of this, so far little attention has been paid to the shift-dependence of the moiré superlattice.In this Letter we consider the dynamical consequence of the relative shift in a van der Waals heterostructure. We show that a sliding motion between the two layers of a moiré superlattice will induce an electric current. In particular, when the Fermi energy lies in one of the minigaps, the system realizes a two-dimensional version of the topological Thouless pump [20]. We first give a general argument of this phenomena by analyzing the motion of the moiré potential and the symmetry of the heterostructures. Interestingly, we find that a chiral charge pump, namely, a transverse current induced by the sliding motion, is possible in twisted homobilayers [ Fig. 1(a)]. This result is further confirmed by a concrete calculation of the adiabatic current in twisted bilayer graphene, where (a) (c) (b) sliding FIG. 1. (a) A relative shif...