We explore the effect of using two-dimensional matter-wave vortices to confine an ensemble of bosonic quantum impurities. This is modelled theoretically using a mass-imbalanced homogeneous two component Gross-Pitaevskii equation. By changing the mass imbalance of our system we find the shape of the vortices are deformed even at modest imbalances, leading to 'barrel' shaped vortices; which we quantify using a multi-component variational approach. The energy of impurity carrying vortex pairs are computed, revealing a mass-dependent energy splitting. We then compute the excited states of the impurity, which we in turn use to construct 'covalent bonds' for vortex pairs, leading to the prediction of impurity mediated bound states. Our work opens a new route to simulating synthetic chemical reactions with superfluid systems.