Topological disintegration of resting state functional connectomes in coma

Malagurski, Brigitta; Péran, Patrice; Sarton, Benjamine; Vinour, Hélène; Naboulsi, Edouard; Riu, Béatrice; Vardon-Bounes, Fanny; Seguin, Thierry; Lotterie, Jean Albert; Fourcade, Olivier; Minville, Vincent; Ferré, Fabrice; Achard, Sophie; Silva, Stein

doi:10.1016/j.neuroimage.2019.03.012

Cited by 22 publications

(25 citation statements)

References 40 publications

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“…Such results may be caused by the following two reasons. First, coma patients have been found to have a lower number of significant functional connections (Chennu et al, 2014 ; Malagurski et al, 2019 ), whereas MCS patients have been demonstrated to retain whole-brain functional connectivity (van den Heuvel et al, 2017 ; Malagurski et al, 2019 ). As such, stimulus information may be transmitted to other brain regions through these reserved connections.…”

Section: Discussionmentioning

confidence: 99%

“…Based on these approaches, recent studies have shown that both qualitative assessments by experts (Forgacs et al, 2014 ; Estraneo et al, 2016 ; Piarulli et al, 2016 ; Bagnato et al, 2017 ) and quantitative assessments using quasi-automated machine learning (Sitt et al, 2014 ) could be valid in evaluating the state of consciousness of patients by EEGs. Furthermore, some studies have reported that different resting-state functional networks characterize healthy and DOC subjects and that their consciousness levels are relevant to their network properties (Chennu et al, 2014 , 2017 ; Malagurski et al, 2019 ). These findings suggest that using resting-state EEGs and graph theory to study DOC patients is feasible and may help to further understand and treat DOCs.…”

Section: Introductionmentioning

confidence: 99%

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Effects of High-Definition Transcranial Direct-Current Stimulation on Resting-State Functional Connectivity in Patients With Disorders of Consciousness

Zhang

Guo

et al. 2020

Front. Hum. Neurosci.

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Recently a positive treatment effect on disorders of consciousness (DOCs) with high-definition transcranial direct-current stimulation (HD-tDCS) has been reported; however, the neural modulation mechanisms of this treatment's efficacy need further investigation. To better understand the processing of HD-tDCS interventions, a long-lasting HD-tDCS protocol was applied to 15 unresponsive wakefulness syndrome (UWS) patients and 20 minimally conscious states (MCS) patients in this study. Ten minutes of resting-state electroencephalograms (EEGs) were recorded from the patients, and the coma recovery scale-revised scores (CRS-Rs) were assessed for each patient from four time-points (T0, T1, T2, and T3). Brain networks were constructed by calculating the EEG spectral connectivity using the debiased weighted phase lag index (dwPLI) and then quantified the network information transmission efficiency by graph theory. We found that there was an increasing trend in local and global information processing of beta and gamma bands in resting-state functional brain networks during the 14 days of HD-tDCS modulation for MCS patients. Furthermore, the increased functional connectivity not only occurred in the local brain area surrounding the stimulation position but was also present across more global brain areas. Our results suggest that long-lasting HD-tDCS on the precuneus may facilitate information processing among neural populations in MCS patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of High-Definition Transcranial Direct-Current Stimulation on Resting-State Functional Connectivity in Patients With Disorders of Consciousness

Zhang

Guo

et al. 2020

Front. Hum. Neurosci.

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“…Currently, no tool exists to measure consciousness or self-consciousness objectively by any machine [65]. In non-communicative patients, its estimation requires the interpretation of motor responsiveness [66]. This response represents active brain processing events in the Primary Motor Cortex (MI, area 4) in the precentral gyrus and the corticospinal tract which has its own relationship to somatotopic organization for specific movement coordination, in general with other sensory processing information via a major thalamic motor nucleus, including its ventral…”

Section: Measurement Of Conscious-state Transition Capacity Under Euthanatic Administrationmentioning

confidence: 99%

The Need for XR-Measurement of Decision-Making Decline and Conscious-State Transition Impairment before Nonvoluntary Euthanization of Dementia Patients

Campbell¹

2021

Suggestions for Addressing Clinical and Non-Clinical Issues in Palliative Care

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Non-voluntary euthanization of dementia patients, the majority of whom are severely conscious-state transition-impaired because of both high levels of anti-somnogenic cytokine levels and circadian disruption, indicates the lack of measurement of decision-making decline and conscious-state transition in palliative care settings. This chapter explains why and how to setup medically-meaningful tests to collect these measurements based on environmental-interactive parameters of nonconscious testing in circadian calibrated XR or virtual reality platforms. It also mentions worthy opportunities in relationship to the Human Connectome Project, including the Alzheimer’s Disease Connectome Project.

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“…Graph theory is one of the methods that has been applied in studying the connection within or between brain networks for patients with DOC, 10,11 due to the fact that functional integration could play a crucial role in supporting consciousness. 12–14 In the graph theoretical analysis, cortical hub regions were defined as nodes with much high functional connectivity with other nodes in the brain, 15 which could promote the functional integration across various components of the network.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies using this method have found that cortical hubs were largely reorganized in DOC patients compared to fully conscious volunteers. 10,11 Moreover, previous studies have showed that cortical hubs play a key role in supporting consciousness. For instance, some studies have found some similarity in hub distributions among DOC and other recoverable unconscious states, such as deep sleep and anesthesia.…”

Section: Introductionmentioning

confidence: 99%

The cortical hubs related to recovery of consciousness

Zhou

Zhang

et al. 2021

Preprint

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Background and ObjectivesThe neural mechanism that enables the recovery of consciousness in patients with unresponsive wakefulness syndrome (UWS) remains unclear. The aim of the current study is to characterize the cortical hub regions related to the recovery of consciousness in patients with UWS.MethodsVoxel-wise degree centrality analysis was adopted to identify the cortical hubs related to the recovery of consciousness, for which a total of 27 UWS patients were used, including 13 patients who emerged from UWS (UWS-E), and 14 patients who remained in UWS (UWS-R) at least three months after the experiment performance. Furthermore, other recoverable unconscious states including three independent deep sleep datasets (n = 12, 9, 9 respectively) and three independent anesthesia datasets (n = 27, 14, 6 respectively) were adopted as validation groups. Spatial similarity of the hub characteristic with the validation groups between the UWS-E and UWS-R was compared using the dice coefficient. Finally, with the cortical regions persistently shown as hubs across UWS-E and validation states, functional connectivity analysis was further performed to explore the connectivity patterns underlying the recovery of consciousness.ResultsFour cortical hubs were identified with significantly higher degree centrality for UWS-E than UWS-R, including the anterior precuneus, left inferior parietal lobule, left inferior frontal gyrus, and left middle frontal gyrus, of which the degree centrality value also positively correlated with the patients’ Glasgow Outcome Scale (GOS) score. Furthermore, the anterior precuneus was found to show significantly higher similarity of hub characteristics as well as functional connectivity pattern between UWS-E and validation groups, compared with UWS-R.DiscussionThe results suggest that the recovery of consciousness may be relevant to the integrity of cortical hubs, especially the anterior precuneus. The identified cortical hub regions could serve as potential targets for noninvasive stimulation aimed at promoting the patients’ consciousness recovery.

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Topological disintegration of resting state functional connectomes in coma

Cited by 22 publications

References 40 publications

Effects of High-Definition Transcranial Direct-Current Stimulation on Resting-State Functional Connectivity in Patients With Disorders of Consciousness

Effects of High-Definition Transcranial Direct-Current Stimulation on Resting-State Functional Connectivity in Patients With Disorders of Consciousness

The Need for XR-Measurement of Decision-Making Decline and Conscious-State Transition Impairment before Nonvoluntary Euthanization of Dementia Patients

The cortical hubs related to recovery of consciousness

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