Topological index is one of the significant tools in chemical graph theory, and is designed to transform a molecular map into a number. Basically, topological index is a single numeric quantity which characterises the entire chemical structure of a compound. Topological indices are crucial relevance to the physicochemical properties of the molecular compounds and also predicting their bioactivity. As an n-type semiconducting metal oxide, cubic tungsten trioxide (hereafter c − WO 3 ) nanostructure has been considered as a potential candidate, which offers manifold applications. Therefore, the chemistry of c − WO 3 is very important and its interdisciplinary study provides a way to understand the importance of various domains. In this study, we computed certain degree based Zagreb and Randić topological indices for c −WO 3 nanomultilayer for all values of p, q and r by adopting edge partition technique. The computational results are analysed, compared and the general formulas to the indices are obtained.