We study the properties of one-dimensional topological superconductors under the influence of generic boundary conditions mimicking the coupling with external environments. We identify a general four-parameters classification of the boundary effects and show that particle-hole and reflection symmetries can be broken or preserved by appropriately fixing the boundary parameters. When the particle-hole symmetry is broken, the topological protection of the edge modes is lost due to the hybridization with the external degrees of freedom (quasiparticle poisoning). We assess the robustness of the edge modes in the various regimes by considering different quantifiers of topological properties. In particular, we investigate the resilience of the long-distance, edge-to-edge quantum mutual information and squashed entanglement, measuring the nonlocal correlations of the Majorana excitations. Besides their relevance for the open dynamics of topological systems, these results may provide a useful guide to the appropriate embedding of low-dimensional topological systems on nanodevices in realistic conditions.